Figure 2. Representative ultrastructural appearances of impaired lungs in normal group (a) and in blast injury groups at 10 cm (b, c), 15 cm (d–f), 20 cm (g, h), and 30 cm (i). a: normal lung; b: swelling of pulmonary microvascular endothelial cells with nuclear swelling; c: necrosis of pulmonary microvascular endothelial cells; d: significantly widened gaps between pulmonary microvascular endothelial cells; e: red blood cells escaped through the alveolar wall; f: swelling observed in the pulmonary capillary endothelial cells and neutrophils incarcerated in the endovascular system; g and h: pulmonary capillary endothelial cell swelling; i: no cell swelling was observed.

Figure

Representative

ultrastructural

appearances

of

impaired

lungs

in

normal

group

a

and

in

blast

injury

groups

at

cm

b

c

cm

d

f

cm

g

h

and

cm

i

a

normal

lung

b

swelling

of

pulmonary

microvascular

endothelial

cells

with

nuclear

swelling

c

necrosis

of

pulmonary

microvascular

endothelial

cells

d

significantly

widened

gaps

between

pulmonary

microvascular

endothelial

cells

e

red

blood

cells

escaped

through

the

alveolar

wall

f

swelling

observed

in

the

pulmonary

capillary

endothelial

cells

and

neutrophils

incarcerated

in

the

endovascular

system

g

and

h

pulmonary

capillary

endothelial

cell

swelling

i

no

cell

swelling

was

observed


Figure 4 Clinical example of the signet ring cell carcinoma associated with infiltrative intramucosal spread. A: An endoscopic image of an EGC, showing a flat lesion located in the lesser curvature of the lower body (circle). Endoscopically, the surrounding mucosa exhibited atrophic gastritis; B: After endoscopic resection, three of the lateral margins were positive (circle); C: Pathological findings after endoscopic resection (× 40). Signet ring cell carcinoma cells exhibited subepithelial spread. In other words, the lesion was of the infiltrative type (circle). Taken with permission from Gut Liver 2015; 9: 720-726[40].

Figure

Clinical

example

of

the

signet

ring

cell

carcinoma

associated

with

infiltrative

intramucosal

spread

A

An

endoscopic

image

of

an

EGC

showing

a

flat

lesion

located

in

the

lesser

curvature

of

the

lower

body

circle

Endoscopically

the

surrounding

mucosa

exhibited

atrophic

gastritis

B

After

endoscopic

resection

three

of

the

lateral

margins

were

positive

circle

C

Pathological

findings

after

endoscopic

resection

Signet

ring

cell

carcinoma

cells

exhibited

subepithelial

spread

In

other

words

the

lesion

was

of

the

infiltrative

type

circle

Taken

with

permission

from

Gut

Liver


Figure 2. A) T1-weighted magnetic resonance imaging in axial plane shows normal origin of coronary arteries, with coronary ostia (arrows), and the proximal portion of the left anterior descending and circumflex arteries. Descending aorta located on the right side. B) Threedimensional coronary MR angiography shows normal path of right coronary artery. C) Three-dimensional coronary MR angiography shows normal path of left anterior descending and circumflex arteries. Dao: descending aorta; Cx: circumflex artery; LAD: left anterior descending; RCA: right coronary artery.

Figure

A

magnetic

resonance

imaging

in

axial

plane

shows

normal

origin

of

coronary

arteries

with

coronary

ostia

arrows

and

the

proximal

portion

of

the

left

anterior

descending

and

circumflex

arteries

Descending

aorta

located

on

the

right

side

B

Threedimensional

coronary

MR

angiography

shows

normal

path

of

right

coronary

artery

C

Three

dimensional

coronary

MR

angiography

shows

normal

path

of

left

anterior

descending

and

circumflex

arteries

Dao

descending

aorta

Cx

circumflex

artery

LAD

left

anterior

descending

RCA

right

coronary

artery


Fig 2. Immunohistochemical labeling of normal oral mucosa (A,D,G), oral leukoplakia (B,E,H) and oral squamous cell carcinoma (G,H,I) for MMP9 (A,B,C), BGH3 (D,E,F) and PDIA3 (G,H,I). Brown staining represents positive expression of proteins. MMP9 expression in stroma cells is low (A). Positive MMP9 cytoplasmic staining of basal cells in OLK (B). Strong nuclear and cytoplasmic MMP9 staining of OSCC (C). Negative BGH3 expression in NOM (D). Weak or moderate BGH3 staining of the basement membrane in OLK (E). Strong positive BGH3 expression in tumor basement membrane and extracellular skeletal stroma of OSCC (F). Negative PDIA3 staining in NOM (G). Moderate to strong PDIA3 staining in the cytoplasm and nucleus of OLK epithelium cells (H). High PDIA3 expression in the cytoplasm and cell membrane of OSCC (I). doi:10.1371/journal.pone.0146530.g002

Fig

Immunohistochemical

labeling

of

normal

oral

mucosa

A

D

G

oral

leukoplakia

B

E

H

and

oral

squamous

cell

carcinoma

G

H

I

for

A

B

C

D

E

F

and

G

H

I

Brown

staining

represents

positive

expression

of

proteins

expression

in

stroma

cells

is

low

A

Positive

cytoplasmic

staining

of

basal

cells

in

OLK

B

Strong

nuclear

and

cytoplasmic

staining

of

OSCC

C

Negative

expression

in

NOM

D

Weak

or

moderate

staining

of

the

basement

membrane

in

OLK

E

Strong

positive

expression

in

tumor

basement

membrane

and

extracellular

skeletal

stroma

of

OSCC

F

Negative

staining

in

NOM

G

Moderate

to

strong

staining

in

the

cytoplasm

and

nucleus

of

OLK

epithelium

cells

H

High

expression

in

the

cytoplasm

and

cell

membrane

of

OSCC

I


Fig. 1 -AFM image of a typical Cryptosporidium parvum oocyst obtained in soft contact (electrical double layer and steric force) mode. The image was obtained with a sharpened silicon nitride cantilever at pH 8.5 and at 1 mM KNO 3 : (a) 3.4 lm scan, the total z-range of the figure is 1000 nm and the edge of a second oocyst can be observed in the top left corner of the image. (b) 1.25 lm scan showing the roughness of the oocyst surface. Reprinted with permission form Considine et al. (2001). Copyright (2001) American Chemical Society.

Fig

-AFM

image

of

a

typical

Cryptosporidium

parvum

oocyst

obtained

in

soft

contact

electrical

double

layer

and

steric

force

mode

The

image

was

obtained

with

a

sharpened

silicon

nitride

cantilever

at

pH

and

at

mM

KNO

a

lm

scan

the

total

z

range

of

the

figure

is

nm

and

the

edge

of

a

second

oocyst

can

be

observed

in

the

top

left

corner

of

the

image

b

lm

scan

showing

the

roughness

of

the

oocyst

surface

Reprinted

with

permission

form

Considine

et

al

Copyright

American

Chemical

Society


Fig. 1. Boundaries of retinal vascular plexuses and retinal layer segmentation. Optical coherence tomography B-scans with angio-flow showing the retinal segmentation in the different capillary plexuses (top and middle) and the segmentation of the retinal layers (bottom). A. B-scan showing the boundaries (red and green lines) that delineate the SVP between the ILM and 9 mm above the junction between the IPL-INL. B. B-scan showing the boundaries (green and red lines) that delineate the DVC between 9 mm above the IPL-INL junction and 9 mm below the OPL-ONL; there is no overlap between the 2 previous slabs. C. B-scan showing the boundaries (green and red lines) that delineate the ICP between 9 mm above the IPL-INL junction and 6 mm below the INL-OPL junction, thus including parts of the IPL and OPL and all the INL. D. Bscan showing the boundaries (red lines) that delineate the DCP between 6 mm below the INL-OPL junction and 9 mm below the OPL-ONL junction, thus including the OPL. E. Bscan showing the retinal layer segmentation provided by AngioAnalytic software. From the inner retina to the outer retina: white line (ILM), yellow line (outer boundary of the nerve fiber layer), orange line (outer boundary of the IPL), red line (outer boundary of the INL), violet line (outer boundary of the OPL), and purple line (outer boundary of the retinal pigment epithelium).

Fig

Boundaries

of

retinal

vascular

plexuses

and

retinal

layer

segmentation

Optical

coherence

tomography

B

scans

with

angio

flow

showing

the

retinal

segmentation

in

the

different

capillary

plexuses

top

and

middle

and

the

segmentation

of

the

retinal

layers

bottom

A.

B

scan

showing

the

boundaries

red

and

green

lines

that

delineate

the

SVP

between

the

ILM

and

mm

above

the

junction

between

the

IPL

INL

B.

B

scan

showing

the

boundaries

green

and

red

lines

that

delineate

the

DVC

between

mm

above

the

IPL

INL

junction

and

mm

below

the

OPL

ONL

there

is

no

overlap

between

the

previous

slabs

C.

B

scan

showing

the

boundaries

green

and

red

lines

that

delineate

the

ICP

between

mm

above

the

IPL

INL

junction

and

mm

below

the

INL

OPL

junction

thus

including

parts

of

the

IPL

and

OPL

and

all

the

INL

D.

Bscan

showing

the

boundaries

red

lines

that

delineate

the

DCP

between

mm

below

the

INL

OPL

junction

and

mm

below

the

OPL

ONL

junction

thus

including

the

OPL

E.

Bscan

showing

the

retinal

layer

segmentation

provided

by

AngioAnalytic

software

From

the

inner

retina

to

the

outer

retina

white

line

ILM

yellow

line

outer

boundary

of

the

nerve

fiber

layer

orange

line

outer

boundary

of

the

IPL

red

line

outer

boundary

of

the

INL

violet

line

outer

boundary

of

the

OPL

and

purple

line

outer

boundary

of

the

retinal

pigment

epithelium


Fig. 1. Brain magnetic resonance imaging show diffuse astrocytoma in the anterior third ventricle and hypothalamus. Sagittal FLAIR image (A), T2-weighted axial image (B), and T1-weighted axial image after administration of gadolinium (C) show an ill-defined lesion with nodular enhancement, which involves the anterior third ventricle and bilateral hypothalamis (arrowhead). The images before treatment also show compression and inferiorly displacement of the midbrain including the substantia nigra by the tumor mass and obstructive hydrocephalus secondary to the tumor (arrow). The images after treatment with surgical excision and cerebrospinal fluid drainage show significant decrease of the tumor and lateral ventricles, and consequent improvement of midbrain compression (D, E and F). D

Fig

Brain

magnetic

resonance

imaging

show

diffuse

astrocytoma

in

the

anterior

third

ventricle

and

hypothalamus

Sagittal

FLAIR

image

A

axial

image

B

and

axial

image

after

administration

of

gadolinium

C

show

an

ill

defined

lesion

with

nodular

enhancement

which

involves

the

anterior

third

ventricle

and

bilateral

hypothalamis

arrowhead

The

images

before

treatment

also

show

compression

and

inferiorly

displacement

of

the

midbrain

including

the

substantia

nigra

by

the

tumor

mass

and

obstructive

hydrocephalus

secondary

to

the

tumor

arrow

The

images

after

treatment

with

surgical

excision

and

cerebrospinal

fluid

drainage

show

significant

decrease

of

the

tumor

and

lateral

ventricles

and

consequent

improvement

of

midbrain

compression

D

E

and

F

D


Fig. 1 Incomplete burst fracture of the second lumbar vertebral body vertebra a initial X-rays lateral, b computed tomography axial plane showing the damage of the posterior wall and narrowing of the spinal canal of approximately 30%, c, d X-rays in two planes after kyphoplasty

Fig

Incomplete

burst

fracture

of

the

second

lumbar

vertebral

body

vertebra

a

initial

X

rays

lateral

b

computed

tomography

axial

plane

showing

the

damage

of

the

posterior

wall

and

narrowing

of

the

spinal

canal

of

approximately

c

d

X

rays

in

two

planes

after

kyphoplasty


Figure 1. Sagittal pre-contrast T1 (a), T2 (b), and post-contrast T1 (c) images show an intradural extramedullary serpiginous tubular lesion (solid arrows) extending from T12 to L3, with intermediate signal on T1 weighted images, peripheral hypointensity and central hyperintensity on T2 weighted images (the “doughnut” sign, dotted arrow) and avid homogeneous enhancement. The “doughnut” sign is also present on multiple axial T2 slices (d and e, dotted arrows). Avid enhancement within the lesion is also visualized on axial T1 post-contrast images (f, solid arrow).

Figure

Sagittal

pre

contrast

a

b

and

post

contrast

c

images

show

an

intradural

extramedullary

serpiginous

tubular

lesion

solid

arrows

extending

from

to

with

intermediate

signal

on

weighted

images

peripheral

hypointensity

and

central

hyperintensity

on

weighted

images

the

doughnut

sign

dotted

arrow

and

avid

homogeneous

enhancement

The

doughnut

sign

is

also

present

on

multiple

axial

slices

d

and

e

dotted

arrows

Avid

enhancement

within

the

lesion

is

also

visualized

on

axial

post

contrast

images

f

solid

arrow


Figure 1. Group A (Top): maximum amount of remaining coronal dentin located at the gingival margin before (left column) and after (right column) post cementation and preparation design – no ferrule effect. Buccal view. Group B: maximum amount of remaining coronal dentin located below the half of the preparation height before (left column) and after (right column) post cementation and preparation design. Buccal view. Group C (Bottom): maximum amount of remaining coronal dentin located between half or slightly more than the half of the preparation height before (left column – lingual view) and after (right column – buccal view) post cementation and preparation design.

Figure

Group

A

Top

maximum

amount

of

remaining

coronal

dentin

located

at

the

gingival

margin

before

left

column

and

after

right

column

post

cementation

and

preparation

design

no

ferrule

effect

Buccal

view

Group

B

maximum

amount

of

remaining

coronal

dentin

located

below

the

half

of

the

preparation

height

before

left

column

and

after

right

column

post

cementation

and

preparation

design

Buccal

view

Group

C

Bottom

maximum

amount

of

remaining

coronal

dentin

located

between

half

or

slightly

more

than

the

half

of

the

preparation

height

before

left

column

lingual

view

and

after

right

column

buccal

view

post

cementation

and

preparation

design


Figure 1. CT head showing enlarged right frontal scalp mass. A: axial view non-contrast, B: axial view with contrast, C: Coronal view with contrast.

Figure

CT

head

showing

enlarged

right

frontal

scalp

mass

A

axial

view

non

contrast

B

axial

view

with

contrast

C

Coronal

view

with

contrast


Fig. 2. Scanning electron microscopic image of a control limbal segment with Schlemm’s canal (SC) untouched by a microstent. Trabecular meshwork (TM) tissue was removed leaving only a rim of tissue at the margins of the SC external wall. Single arrow points to collector channels (CC). (A) Double arrow spans across the external wall of SC where the upper head of the double arrow contacts the residual rim of trabecular meshwork. (B) Magnification of region outlined in (A). (C) Dotted rectangles outline areas of elongated somewhat spindle-shaped elevations oriented circumferentially in SC consistent with the presence of nuclear profiles typical of an intact endothelium of SC external wall. (D) Collector channel entrance has one sharply demarcated edge and one sloping edge consistent with an oblique entry to SC. Similar CC characteristics are seen in (B) and (C).

Fig

Scanning

electron

microscopic

image

of

a

control

limbal

segment

with

Schlemm

’s

canal

SC

untouched

by

a

microstent

Trabecular

meshwork

TM

tissue

was

removed

leaving

only

a

rim

of

tissue

at

the

margins

of

the

SC

external

wall

Single

arrow

points

to

collector

channels

CC

A

Double

arrow

spans

across

the

external

wall

of

SC

where

the

upper

head

of

the

double

arrow

contacts

the

residual

rim

of

trabecular

meshwork

B

Magnification

of

region

outlined

in

A

C

Dotted

rectangles

outline

areas

of

elongated

somewhat

spindle

shaped

elevations

oriented

circumferentially

in

SC

consistent

with

the

presence

of

nuclear

profiles

typical

of

an

intact

endothelium

of

SC

external

wall

D

Collector

channel

entrance

has

one

sharply

demarcated

edge

and

one

sloping

edge

consistent

with

an

oblique

entry

to

SC

Similar

CC

characteristics

are

seen

in

B

and

C


Figure 2 - Juvenile nasopharyngeal angiofibroma, case P5, Radkowski grade 2c. Axial CT (A) and MRI T2-weighted scans (B) showing a mass in the dorsal two thirds of the left nasal cavity and in the sphenoid sinus (marked by S) with a bulky extension to the pterygopalatine fossa and the ITF. Extensive anteroposterior widening of the sphenopalatine foramen is marked by arrows. (C) An axial MRI T2-weighted scan one year after surgery demonstrating no evidence of disease.

Figure

Juvenile

nasopharyngeal

angiofibroma

case

Radkowski

grade

Axial

CT

A

and

MRI

scans

B

showing

a

mass

in

the

dorsal

two

thirds

of

the

left

nasal

cavity

and

in

the

sphenoid

sinus

marked

by

S

with

a

bulky

extension

to

the

pterygopalatine

fossa

and

the

ITF

Extensive

anteroposterior

widening

of

the

sphenopalatine

foramen

is

marked

by

arrows

C

An

axial

MRI

scan

one

year

after

surgery

demonstrating

no

evidence

of

disease


Fig. 3. Radiograph images. (A) Anteroposterior (AP) radiograph of 31-year-old woman showed posterior dislocation with acetabular fracture. (B) Acetabular was reducted and fixed with recon-plate. (C) AP radiograph showed a total hip replacement arthroplasty state using 36-mm femoral head with highly cross-linked polyethylene. (D) Dislocation state.

Fig

Radiograph

images

A

Anteroposterior

AP

radiograph

of

old

woman

showed

posterior

dislocation

with

acetabular

fracture

B

Acetabular

was

reducted

and

fixed

with

recon

plate

C

AP

radiograph

showed

a

total

hip

replacement

arthroplasty

state

using

femoral

head

with

highly

cross

linked

polyethylene

D

Dislocation

state


Figure 1. Initial computed tomography (CT) and [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). (A) CT scan showed multiple nodules and edema in the bilateral cerebral hemispheres. (B) CT scan showed swelling of the mediastinal lymph nodes (arrowhead). (C) CT scan showed upper abdominal lymph node swelling (arrowhead). (D) FDG-PET scan demonstrated high FDG uptake at the same lymph nodes detected via CT scan (arrowhead).

Figure

Initial

computed

tomography

CT

and

FDG

positron

emission

tomography

PET

A

CT

scan

showed

multiple

nodules

and

edema

in

the

bilateral

cerebral

hemispheres

B

CT

scan

showed

swelling

of

the

mediastinal

lymph

nodes

arrowhead

C

CT

scan

showed

upper

abdominal

lymph

node

swelling

arrowhead

D

FDG

PET

scan

demonstrated

high

FDG

uptake

at

the

same

lymph

nodes

detected

via

CT

scan

arrowhead


Figure 1. A pretreatment multimodal imaging study of a 32-year-old Caucasian woman who presented with multifocal choroiditis with panuveitis (MCP) in her right eye. (A) Ultra-wide field color fundus image. (B) Fluorescein angiography (FA). (C) Indocyanine green angiography (ICGA). (D) Fundus autofluorescence (FAF) ultrawide field image. The yellow circles indicate the singled out active lesion being studied.

Figure

A

pretreatment

multimodal

imaging

study

of

a

old

Caucasian

woman

who

presented

with

multifocal

choroiditis

with

panuveitis

MCP

in

her

right

eye

A

Ultra

wide

field

color

fundus

image

B

Fluorescein

angiography

FA

C

Indocyanine

green

angiography

ICGA

D

Fundus

autofluorescence

FAF

ultrawide

field

image

The

yellow

circles

indicate

the

singled

out

active

lesion

being

studied


Figure 1 (a) Histological section of a UM of mixed cellularity (HE, Â 20 magnification). (b) Immunostaining of the same tumour with clear nuclear cyclin D1 staining (APAAP, Â 20 magnification).

Figure

a

Histological

section

of

a

UM

of

mixed

cellularity

HE

Â

magnification

b

Immunostaining

of

the

same

tumour

with

clear

nuclear

cyclin

staining

APAAP

Â

magnification


Fig. 2. (a) T2 fat-saturation MRI sequence with the intrapancreatic process of similar intensity to that of the spleen. (b) The negative spleen-SPECT of the intrapancreatic process due to its small size.

Fig

a

fat

saturation

MRI

sequence

with

the

intrapancreatic

process

of

similar

intensity

to

that

of

the

spleen

b

The

negative

spleen

SPECT

of

the

intrapancreatic

process

due

to

its

small

size


Figure 2. Clearly delimited homogeneous nodules, anterior to the gastric antrum and in the right iliac fossa, isodense to the liver at unenhanced CT images and with intense and homogenous enhancement on the contrast enhancement CT images. a: CT: axial unenhanced CT image (December 2008); b: CT: axial contrast-enhanced portal phase CT image (December 2008); c: CT: axial contrast-enhanced portal phase CT images (April 2009).

Figure

Clearly

delimited

homogeneous

nodules

anterior

to

the

gastric

antrum

and

in

the

right

iliac

fossa

isodense

to

the

liver

at

unenhanced

CT

images

and

with

intense

and

homogenous

enhancement

on

the

contrast

enhancement

CT

images

a

CT

axial

unenhanced

CT

image

December

b

CT

axial

contrast

enhanced

portal

phase

CT

image

December

c

CT

axial

contrast

enhanced

portal

phase

CT

images

April


Figure 2 (A) Digital volumetric reconstruction of the CT scan depicting the relative positions of the uterine tandem with the small bowel (blue) the uterine body ( pink); (B) A correct application shown for depicting the intended position of the uterine tandem, within the uterus.

Figure

A

Digital

volumetric

reconstruction

of

the

CT

scan

depicting

the

relative

positions

of

the

uterine

tandem

with

the

small

bowel

blue

the

uterine

body

pink

B

A

correct

application

shown

for

depicting

the

intended

position

of

the

uterine

tandem

within

the

uterus


Fig. 1 Pre-operative imaging. a Plain skull radiography on index presentation. b Axial CT imaging. c Axial T2-weighted MR imaging, both taken 9 months later

Fig

Pre

operative

imaging

a

Plain

skull

radiography

on

index

presentation

b

Axial

CT

imaging

c

Axial

MR

imaging

both

taken

months

later


Figure 1. FESEM images of (A) Chitosan, (B) Gr-Au, (C) Gr-Au-Chit and (D) Gr-Au-Chit/Tyr, (E) EDX spectrum surface of Gr-Au-modified SPCE. EDX = Energy Dispersive X-Ray spectroscopy; SPCE = screen-printed carbon electrode.

Figure

FESEM

images

of

A

Chitosan

B

Gr

Au

C

Gr

Au

Chit

and

D

Gr

Au

Chit

Tyr

E

EDX

spectrum

surface

of

Gr

Au

modified

SPCE

EDX

Energy

Dispersive

X

Ray

spectroscopy

SPCE

screen

printed

carbon

electrode


Figure 3. Measurement of the axial condylar angle of the condylar process (A). It was defined as the angle between the long axis of the mandibular condylar process and a perpendicular line to the midsagittal plane.7

Figure

Measurement

of

the

axial

condylar

angle

of

the

condylar

process

A

It

was

defined

as

the

angle

between

the

long

axis

of

the

mandibular

condylar

process

and

a

perpendicular

line

to

the

midsagittal


Fig. 3 A 63-year-old woman presented in emergency with acute abdominal pain and elevated serum lactate (3.1 mmol/ l). Axial (a, b) and coronal (c) MDCT images reveal a rectosigmoid cancer (a, white arrow) causing mechanical obstruction with proximal luminal dilatation, fecal stasis (b–c) and PI (b, black arrows). Total colectomy was immediately performed, resecting both the tumour and the whole proximal colon because of ischemic necrosis of the latter

Fig

A

old

woman

presented

in

emergency

with

acute

abdominal

pain

and

elevated

serum

lactate

mmol/

l

Axial

a

b

and

coronal

c

MDCT

images

reveal

a

rectosigmoid

cancer

a

white

arrow

causing

mechanical

obstruction

with

proximal

luminal

dilatation

fecal

stasis

b

c

and

PI

b

black

arrows

Total

colectomy

was

immediately

performed

resecting

both

the

tumour

and

the

whole

proximal

colon

because

of

ischemic

necrosis

of

the

latter


Figure 2. Figure A shows the T2prep image of the RCA in a patient with CAD, while B represents the x-ray angiography and C the IR scan pre and D the IR scan post gadolinium administration in the same patient. At the bottom right of Figure 1D is the enlarged cross sectional view of the appended IR scan. doi:10.1371/journal.pone.0050655.g002

Figure

Figure

A

shows

the

image

of

the

RCA

in

a

patient

with

CAD

while

B

represents

the

x

ray

angiography

and

C

the

IR

scan

pre

and

D

the

IR

scan

post

gadolinium

administration

in

the

same

patient

At

the

bottom

right

of

Figure

is

the

enlarged

cross

sectional

view

of

the

appended

IR

scan


Figure 1: Preoperative magnetic resonance imaging of a 57-year-old female with radicular chronic pain and pitting oedema in the bilateral lower extremities showing disc protrusion of the (A) L3–L4 and (B) L4–L5 vertebrae with foraminal stenosis.

Figure

Preoperative

magnetic

resonance

imaging

of

a

old

female

with

radicular

chronic

pain

and

pitting

oedema

in

the

bilateral

lower

extremities

showing

disc

protrusion

of

the

A

and

B

vertebrae

with

foraminal

stenosis


Figure 14. Lipoma in a 77-year-old man with a foreign body sensation, episodes of suffocation, and change in voice quality. (a) Axial contrast-enhanced CT scan obtained at the supraglottic level shows a homogeneous, nonenhancing lesion isoattenuating to fat at the level of the right aryepiglottic fold (arrowhead). (b) Endoscopic image demonstrates a pedunculated mass covered by intact laryngeal mucosa arising from the right aryepiglottic fold (arrowhead). (c) Low-power photomicrograph (original magnification, x25; hematoxylin-eosin stain) shows intact overlying squamous epithelium (arrows). Lobulated laryngeal lipoma composed of mature adipocytes (*) and a fibrous pseudocapsule (arrowheads) are also seen. The patient underwent endoscopic resection and is free of recurrence 5 years later.

Figure

Lipoma

in

a

old

man

with

a

foreign

body

sensation

episodes

of

suffocation

and

change

in

voice

quality

a

Axial

contrast

enhanced

CT

scan

obtained

at

the

supraglottic

level

shows

a

homogeneous

nonenhancing

lesion

isoattenuating

to

fat

at

the

level

of

the

right

aryepiglottic

fold

arrowhead

b

Endoscopic

image

demonstrates

a

pedunculated

mass

covered

by

intact

laryngeal

mucosa

arising

from

the

right

aryepiglottic

fold

arrowhead

c

Low

power

photomicrograph

original

magnification

hematoxylin

eosin

stain

shows

intact

overlying

squamous

epithelium

arrows

Lobulated

laryngeal

lipoma

composed

of

mature

adipocytes

and

a

fibrous

pseudocapsule

arrowheads

are

also

seen

The

patient

underwent

endoscopic

resection

and

is

free

of

recurrence

years

later


Figure 3. Transmission electron microscopy (TEM) to reveal lipid droplets on colorectal cells. (A–F): TEM images of the CR-CSCs, their differentiated forms (SDACs), CCCs, and NECCs. (A and B), parasagittal sections of (A) CR-CSCs and (B) SDACs belonging to human patient 1; (C and D), parasagittal sections of (C) CR-CSCs and (D) SDACs belonging to human patient 2; (E), parasagittal section of a CCC; (F), parasagittal section of a NECC. White arrowheads point to mitochondria; black arrowheads point to multivesicular bodies and late-endosome/lysosome hybrids. LDs are colored in red. n, nucleus. (G): TEM image of a LD in cross-section. The asterisk points to the endoplasmic reticulum. Inset: detail of the LD single membrane leaflet. (H): Volume fraction of LDs in the cytoplasm and in the whole cell. Error bars, SEM. Statistical significance is denoted by * (p .01, Student’s t test). Scale bars are 4 mm for A–F and 100 nm for G. Abbreviations: CCC, colon carcinoma cell; CR-CSC, colorectal cancer stem cell; NECC, normal epithelial colon cell; SDAC, sphere-derived adherent cell.

Figure

Transmission

electron

microscopy

TEM

to

reveal

lipid

droplets

on

colorectal

cells

A

F

TEM

images

of

the

CR

CSCs

their

differentiated

forms

SDACs

CCCs

and

NECCs

A

and

B

parasagittal

sections

of

A

CR

CSCs

and

B

SDACs

belonging

to

human

patient

C

and

D

parasagittal

sections

of

C

CR

CSCs

and

D

SDACs

belonging

to

human

patient

E

parasagittal

section

of

a

CCC

F

parasagittal

section

of

a

NECC

White

arrowheads

point

to

mitochondria

black

arrowheads

point

to

multivesicular

bodies

and

late

endosome

lysosome

hybrids

LDs

are

colored

in

red

n

nucleus

G

TEM

image

of

a

LD

in

cross

section

The

asterisk

points

to

the

endoplasmic

reticulum

Inset

detail

of

the

LD

single

membrane

leaflet

H

Volume

fraction

of

LDs

in

the

cytoplasm

and

in

the

whole

cell

Error

bars

SEM

Statistical

significance

is

denoted

by

p

Student

’s

t

test

Scale

bars

are

mm

for

A

F

and

nm

for

G.

Abbreviations

CCC

colon

carcinoma

cell

CR

CSC

colorectal

cancer

stem

cell

NECC

normal

epithelial

colon

cell

SDAC

sphere

derived

adherent

cell


Figure 2. (a) Oblique sagittal reformatted view of the pelvis CT scan (bone window, slice thickness 1 mm) acquired after osteosynthesis (first step of the procedure). The first screw was placed into the iliac bone from the posterior iliac crest to the anterior inferior iliac spine along the arcuate line. The cross section of the proximal part of the second screw inserted into the sacroiliac joint is visible (small arrow). (b) Oblique axial reformatted view of the pelvis CT scan after iliac screw fixation. (c) Oblique axial reformatted view of the pelvis CT scan after sacral screw fixation. This second screw was inserted into the sacroiliac joint to the sacral wing.

Figure

a

Oblique

sagittal

reformatted

view

of

the

pelvis

CT

scan

bone

window

slice

thickness

mm

acquired

after

osteosynthesis

first

step

of

the

procedure

The

first

screw

was

placed

into

the

iliac

bone

from

the

posterior

iliac

crest

to

the

anterior

inferior

iliac

spine

along

the

arcuate

line

The

cross

section

of

the

proximal

part

of

the

second

screw

inserted

into

the

sacroiliac

joint

is

visible

small

arrow

b

Oblique

axial

reformatted

view

of

the

pelvis

CT

scan

after

iliac

screw

fixation

c

Oblique

axial

reformatted

view

of

the

pelvis

CT

scan

after

sacral

screw

fixation

This

second

screw

was

inserted

into

the

sacroiliac

joint

to

the

sacral

wing


Figure 2. (a) an axial view through the Presage dosimeter at a plane through one of the 4 target points. (b) the same image but with central beam line annotations to highlight the cone misalignment.

Figure

a

an

axial

view

through

the

Presage

dosimeter

at

a

plane

through

one

of

the

target

points

b

the

same

image

but

with

central

beam

line

annotations

to

highlight

the

cone

misalignment


Fig. 1. Preoperative sagittal (A) and axial (B) T2-weighted magnetic resonance images reveal a heterogeneous ventral intradural 2.5 cm diameter lesion in the C1-2 region. Sagittal T1-weighted images without enhancement (C) and with enhancement (D) reveal a well enhanced tumor with iso-signal intensity. The preoperative diagnosis was meningioma or schwannoma.

Fig

Preoperative

sagittal

A

and

axial

B

magnetic

resonance

images

reveal

a

heterogeneous

ventral

intradural

cm

diameter

lesion

in

the

region

Sagittal

images

without

enhancement

C

and

with

enhancement

D

reveal

a

well

enhanced

tumor

with

iso

signal

intensity

The

preoperative

diagnosis

was

meningioma

or

schwannoma


Fig. 9 MTX myelopathy. This 7-year-old female treated for ALL 2 years earlier, developed an isolated CNS relapse treated with cranial irradiation and five doses of IT MTX. She subsequently developed lower extremity paraparesis with urinary incontinence. Initial MR study of the spine was normal. a Sagittal T2-weighted noncontrast-enhanced image obtained after 2 weeks of persistent symptoms shows T2 hyperintensity along the dorsal aspect of the thoracic spinal cord (thick arrow). b–e Sagittal T2-weighted

Fig

MTX

myelopathy

This

old

female

treated

for

ALL

years

earlier

developed

an

isolated

CNS

relapse

treated

with

cranial

irradiation

and

five

doses

of

IT

MTX

She

subsequently

developed

lower

extremity

paraparesis

with

urinary

incontinence

Initial

MR

study

of

the

spine

was

normal

a

Sagittal

noncontrast

enhanced

image

obtained

after

weeks

of

persistent

symptoms

shows

hyperintensity

along

the

dorsal

aspect

of

the

thoracic

spinal

cord

thick

arrow

b

e

Sagittal


Figure 3. Dystrobrevin is supplied to chimeric muscle. WT (A), WT/mdx (C) and WT/mdx:utr (D) diaphragm muscle display sarcolemmadystrobrevin (green staining); mdx (B) and WT/mdx (C) diaphragm muscle display sarcolemma-utrophin (red staining); blue: nuclear staining (DAPI); magnification: 2006. doi:10.1371/journal.pone.0020065.g003

Figure

Dystrobrevin

is

supplied

to

chimeric

muscle

WT

A

WT

mdx

C

and

WT

mdx

utr

D

diaphragm

muscle

display

sarcolemmadystrobrevin

green

staining

mdx

B

and

WT

mdx

C

diaphragm

muscle

display

sarcolemma

utrophin

red

staining

blue

nuclear

staining

DAPI

magnification


Fig 1. The mediolateral dimension of the synovial fold in the coronal plane was defined as the distance between lateral cortical margin of the radial head and free edge of the synovial fold (A). In addition, the mediolateral dimension of the radial head was measured using the greatest distance between medial and lateral cortical margins on the coronal images (B).

Fig

The

mediolateral

dimension

of

the

synovial

fold

in

the

coronal

plane

was

defined

as

the

distance

between

lateral

cortical

margin

of

the

radial

head

and

free

edge

of

the

synovial

fold

A

In

addition

the

mediolateral

dimension

of

the

radial

head

was

measured

using

the

greatest

distance

between

medial

and

lateral

cortical

margins

on

the

coronal

images

B


Figure 3. X-ray film of right foot in 16-year-old girl. Preoperative imaging (A) is compared with postoperative imaging at time of surgery (B) and at follow-up evaluation—26 years (C).

Figure

X

ray

film

of

right

foot

in

old

girl

Preoperative

imaging

A

is

compared

with

postoperative

imaging

at

time

of

surgery

B

and

at

follow

up

years

C


Fig. 3. Sagittal (A) and axial CT (B) view of the lumbar spine showing the typical vacuum phenomenon and profound water-like calcification with sparing of the central nucleus pulposus. A B

Fig

Sagittal

A

and

axial

CT

B

view

of

the

lumbar

spine

showing

the

typical

vacuum

phenomenon

and

profound

water

like

calcification

with

sparing

of

the

central

nucleus

pulposus

A

B


Fig. 2 The true lumen (T) and superior mesenteric artery (SMA) were compressed by the expanded false lumen (F). a Sagittal slice, b axial slice at the level of bronchial bifurcation, and c axial slice at the level of the SMA. T true lumen, F false lumen

Fig

The

true

lumen

T

and

superior

mesenteric

artery

SMA

were

compressed

by

the

expanded

false

lumen

F

a

Sagittal

slice

b

axial

slice

at

the

level

of

bronchial

bifurcation

and

c

axial

slice

at

the

level

of

the

SMA

T

true

lumen

F

false

lumen


Fig. 2. MRI of both temporal bones performed 18 days before cochlear implantation. a T1-weighted image. A hyperintense lesion was seen in the basal turn of both cochleae (arrows). b , c Postcontrast T1-weighted images. An enhancing lesion was seen in the basal turn of the right cochlea ( b ; arrow) and in the vestibule of the right ear ( c ; arrow). d T1-weighted image. A hyperintense lesion was seen in the ampulla of the left superior semicircular canal (arrow).

Fig

MRI

of

both

temporal

bones

performed

days

before

cochlear

implantation

a

image

A

hyperintense

lesion

was

seen

in

the

basal

turn

of

both

cochleae

arrows

b

c

Postcontrast

images

An

enhancing

lesion

was

seen

in

the

basal

turn

of

the

right

cochlea

b

arrow

and

in

the

vestibule

of

the

right

ear

c

arrow

d

image

A

hyperintense

lesion

was

seen

in

the

ampulla

of

the

left

superior

semicircular

canal

arrow


Figure 3. Photomicrographs of hematoxylin and eosin stained chicken spleen section. (A) shows the normal histological structure of control group; (B) shows that congestion of red pulp (*) is obvious in 100% group. At 21 days of age, when compared with those of control group (C), nuclear debris and vacuoles (arrows) are gradually increased in the spleen of chickens in 50%, 75% and 100% groups (D–F, respectively).

Figure

Photomicrographs

of

hematoxylin

and

eosin

stained

chicken

spleen

section

A

shows

the

normal

histological

structure

of

control

group

B

shows

that

congestion

of

red

pulp

is

obvious

in

group

At

days

of

age

when

compared

with

those

of

control

group

C

nuclear

debris

and

vacuoles

arrows

are

gradually

increased

in

the

spleen

of

chickens

in

and

groups

D

F

respectively


Figure 7: CT image with window level and settings recommendations for Abdominal CT (a), CT image with dynamic window level and settings (b)

Figure

CT

image

with

window

level

and

settings

recommendations

for

Abdominal

CT

a

CT

image

with

dynamic

window

level

and

settings

b


FIGURE 5 | In vivo and in vitro bioluminescence emission by Y. ruckeri acrR − and acrR + strains. (A) Fish imaged at 4 days post infection carried out by intraperitoneal injection with the acrR − strain. Bioluminescence imaging of acrR − (B) and acrR + (C) strains in presence of different fish tissues deposited on TSA plates previously inoculated with the corresponding strain. Brain (1), heart (2), liver (3), spleen (4), adipose tissue (5), gut (6), gills (7). Color bar shows RLU level.

FIGURE

In

vivo

and

in

vitro

bioluminescence

emission

by

Y.

ruckeri

acrR

and

acrR

strains

A

Fish

imaged

at

days

post

infection

carried

out

by

intraperitoneal

injection

with

the

acrR

strain

Bioluminescence

imaging

of

acrR

B

and

acrR

C

strains

in

presence

of

different

fish

tissues

deposited

on

TSA

plates

previously

inoculated

with

the

corresponding

strain

Brain

heart

liver

spleen

adipose

tissue

gut

gills

Color

bar

shows

RLU

level


Fig. 5 PCNA and OCT-4 expression in bilaterally ovariectomized mouse endometrial section. a, b. PCNA expression was minimal in the epithelial cells lining the lumen and the glands. Stromal cells did not express PCNA. Please note that few cells show relatively intense expression compared to others (arrow). c, d. OCT-4 expression was cytoplasmic in nature however; few spherical cells (arrow) expressed nuclear OCT-4A. Thus the OCT-4 antibody used in the present study helps to clearly delineate the two alternatively spliced isoforms of OCT-4 including nuclear OCT-4A and cytoplasmic OCT-4B. Scale bar 20 μm

Fig

PCNA

and

expression

in

bilaterally

ovariectomized

mouse

endometrial

section

a

b.

PCNA

expression

was

minimal

in

the

epithelial

cells

lining

the

lumen

and

the

glands

Stromal

cells

did

not

express

PCNA

Please

note

that

few

cells

show

relatively

intense

expression

compared

to

others

arrow

c

d.

expression

was

cytoplasmic

in

nature

however

few

spherical

cells

arrow

expressed

nuclear

Thus

the

antibody

used

in

the

present

study

helps

to

clearly

delineate

the

two

alternatively

spliced

isoforms

of

including

nuclear

and

cytoplasmic

Scale

bar

μm


Figure 3: Examples of the performance of different tools on the occipital lobe on a T1 scan. (A) The T1 scan without a segmentation. (B) The T1 scan with an example of a good regional delineation (MALP-EM). (C) The T1 scan with an example of a poor occipital lobe delineation with spillage into the dura in the medial section of the region (SPM 8 Unified Segment). (D) The T1 scan with an example of a poor occipital lobe delineation with spillage into the dura in the medial and superior sections of the region (SPM 8 New Segment). (E) The T1 scan with an example of a poor occipital lobe delineation with spillage into the dura in the medial and superior sections of the region (FSL FAST). The scans are viewed in FSLeyes with the T1 scan as a base image, and the GM region as an overlay. In this figure, the GM regions are viewed as red-yellow with an opacity of 0.4. The color gradient represents partial volume of voxels, with voxels that are more yellow having a higher PVE estimate (more likely to be GM) and those that are red having a lower PVE estimate (less likely to be GM). Please click here to view a larger version of this figure.

Figure

Examples

of

the

performance

of

different

tools

on

the

occipital

lobe

on

a

scan

A

The

scan

without

a

segmentation

B

The

scan

with

an

example

of

a

good

regional

delineation

MALP

EM

C

The

scan

with

an

example

of

a

poor

occipital

lobe

delineation

with

spillage

into

the

dura

in

the

medial

section

of

the

region

SPM

Unified

Segment

D

The

scan

with

an

example

of

a

poor

occipital

lobe

delineation

with

spillage

into

the

dura

in

the

medial

and

superior

sections

of

the

region

SPM

New

Segment

E

The

scan

with

an

example

of

a

poor

occipital

lobe

delineation

with

spillage

into

the

dura

in

the

medial

and

superior

sections

of

the

region

FSL

FAST

The

scans

are

viewed

in

FSLeyes

with

the

scan

as

a

base

image

and

the

GM

region

as

an

overlay

In

this

figure

the

GM

regions

are

viewed

as

red

yellow

with

an

opacity

of

The

color

gradient

represents

partial

volume

of

voxels

with

voxels

that

are

more

yellow

having

a

higher

PVE

estimate

more

likely

to

be

GM

and

those

that

are

red

having

a

lower

PVE

estimate

less

likely

to

be

GM

Please

click

here

to

view

a

larger

version

of

this

figure


Figure 3. Sequential coronal sections stained with Nissl (A) and immunohistochemistry for ␣M␤2 integrin (B) in the hippocampus after carotid occlusion and 30 min of hypoxia. Mild neuronal loss is seen in CA1 (arrow), immunohistochemistry reveals macrophage activation and presence of deramified phagocytes (dashed arrows). Note the activation in CA1 and CA4 with maintenance of CA2 and dentate gyrus (DG).

Figure

Sequential

coronal

sections

stained

with

Nissl

A

and

immunohistochemistry

for

M

integrin

B

in

the

hippocampus

after

carotid

occlusion

and

min

of

hypoxia

Mild

neuronal

loss

is

seen

in

arrow

immunohistochemistry

reveals

macrophage

activation

and

presence

of

deramified

phagocytes

dashed

arrows

Note

the

activation

in

and

with

maintenance

of

and

dentate

gyrus

DG


Fig. 1. Proton density-weighted MRI (TR 3,500 ms, TE 19 ms) shows high signal intensity in the inferior olivary nuclei of patient 1 (a) and patient 2 (b).

Fig

Proton

density

weighted

MRI

TR

ms

TE

ms

shows

high

signal

intensity

in

the

inferior

olivary

nuclei

of

patient

a

and

patient

b


Fig 2 High resolution computed tomograms of two patients whose chest radiographs were normal: (above) ground glass opacification in the posterior segments of the left lower lobe (difficult to identify on a frontal chest radiograph because of location behind the heart); (below) ground glass opacification in the posterior segments of the right lower lobe (difficult to identify on a frontal chest radiograph because of location behind the diaphragm)

Fig

High

resolution

computed

tomograms

of

two

patients

whose

chest

radiographs

were

normal

above

ground

glass

opacification

in

the

posterior

segments

of

the

left

lower

lobe

difficult

to

identify

on

a

frontal

chest

radiograph

because

of

location

behind

the

heart

below

ground

glass

opacification

in

the

posterior

segments

of

the

right

lower

lobe

difficult

to

identify

on

a

frontal

chest

radiograph

because

of

location

behind

the

diaphragm


Fig. 3. A CMB detected with SWI with postmortem 3T MRI (A) is compared with HE staining of the brain block (B) of subject C1. The rectangle in B is enlarged in C and shows accumulation of hemosiderin-laden macrophages around the small vessels (Inset). Scale bars in C: 200 m (inset: 20 m).

Fig

A

CMB

detected

with

SWI

with

postmortem

T

MRI

A

is

compared

with

HE

staining

of

the

brain

block

B

of

subject

The

rectangle

in

B

is

enlarged

in

C

and

shows

accumulation

of

hemosiderin

laden

macrophages

around

the

small

vessels

Inset

Scale

bars

in

C

m

inset

m


FIG. 5. EBNA-1 coexpression results in the increased nuclear accumulation of epitope-tagged p32(74-282). HeLa cells were cotransfected with pE1A-CMX/p32(74-282) and pCMX (A and B), pCMX/EBNA-1 (C and D), pCMX/EBNA-1⌬gly-ala (E and F), pCMX/EBNA-1⌬Box A (G and H), pCMX/EBNA-1⌬Box B/C (I and J), or pCMX/EBNA-1⌬Box A/B/C (K and L) and IF stains were performed 48 h later with mAb M45 to detect epitope-tagged p32(74-282) and an anti-EBNA-1 serum. Primary antibodies were detected with FITC-conjugated goat anti-mouse IgG and TRITC-conjugated goat anti-rabbit IgG. A and B show labeling of M45-p32(74-282) in two different fields of cells. The distribution of M45-p32(74-282) (C, E, G, I, and K) and full-length or mutant EBNA-1 proteins

FIG

coexpression

results

in

the

increased

nuclear

accumulation

of

epitope

tagged

HeLa

cells

were

cotransfected

with

CMX

and

pCMX

A

and

B

pCMX

C

and

D

pCMX

gly

ala

E

and

F

pCMX

Box

A

G

and

H

pCMX

Box

B

C

I

and

J

or

pCMX

Box

A

B

C

K

and

L

and

IF

stains

were

performed

h

later

with

mAb

to

detect

epitope

tagged

and

an

anti

serum

Primary

antibodies

were

detected

with

FITC

conjugated

goat

anti

mouse

IgG

and

TRITC

conjugated

goat

anti

rabbit

IgG.

A

and

B

show

labeling

of

in

two

different

fields

of

cells

The

distribution

of

C

E

G

I

and

K

and

full

length

or

mutant

proteins


Fig. 3 a Combined failure after insufficient correction of sagittal misaligment (improper distal foundation without pelvic fixation and inadequate lordosis). Failure with pullout at S1 and rod breakage. b Revision surgery with extension of fixation to pelvis, multiple SPOs to increase lordosis at L2–L3–L4 and anterior column reconstruction with XLIF at L3–L4–L5 and PLIF at L5–S1

Fig

a

Combined

failure

after

insufficient

correction

of

sagittal

misaligment

improper

distal

foundation

without

pelvic

fixation

and

inadequate

lordosis

Failure

with

pullout

at

and

rod

breakage

b

Revision

surgery

with

extension

of

fixation

to

pelvis

multiple

SPOs

to

increase

lordosis

at

and

anterior

column

reconstruction

with

XLIF

at

and

PLIF

at


FIG. 7. No obvious structures demarcate the pathways taken by growth cones extending towards the fin bud. Cross sections of the 57-hr embryo with diI-labeled growth cones shown in Fig. 6C and 6D. (A) Section showing labeled axons in the S2 nerve approximately 5 pm posterior to the most distal growth cones S, spinal cord; N, notochord; Ax, axial muscles; B, blood vessel; P, pronephros; F, fin bud. (B) Section at the level of the most distal growth cones and filopodia (arrowheads). (C) Section approximately 5 pm anterior to the most distal S2 growth cones. Scale for (A-C), 10 pm

FIG

No

obvious

structures

demarcate

the

pathways

taken

by

growth

cones

extending

towards

the

fin

bud

Cross

sections

of

the

embryo

with

diI

labeled

growth

cones

shown

in

Fig

and

A

Section

showing

labeled

axons

in

the

nerve

approximately

pm

posterior

to

the

most

distal

growth

cones

S

spinal

cord

N

notochord

Ax

axial

muscles

B

blood

vessel

P

pronephros

F

fin

bud

B

Section

at

the

level

of

the

most

distal

growth

cones

and

filopodia

arrowheads

C

Section

approximately

pm

anterior

to

the

most

distal

growth

cones

Scale

for

A

C

pm


Figure 3. Micro-CT graphs of Palaeonummulites venosus (upper row) and Operculina ammonoides (lower row). a micrograph showing all chambers; b equatorial section; c axial section cutting the final chamber; d areas of shell lumina in axial section.

Figure

Micro

CT

graphs

of

Palaeonummulites

venosus

upper

row

and

Operculina

ammonoides

lower

row

a

micrograph

showing

all

chambers

b

equatorial

section

c

axial

section

cutting

the

final

chamber

d

areas

of

shell

lumina

in

axial

section


Figure 2: (a) Preoperative radiograph of right mandibular first molar with immature apices and necrotic pulp and apical radiolucencies. (b) Postoperative radiograph after root canal disinfection, treated dentin matrix fabrication, bleeding induction, and placement of calcium-enriched mixture cement over the blood clot. (c) Follow-up radiograph 6-month postoperation. (d) Follow-up radiograph 12-month postoperation d c

Figure

a

Preoperative

radiograph

of

right

mandibular

first

molar

with

immature

apices

and

necrotic

pulp

and

apical

radiolucencies

b

Postoperative

radiograph

after

root

canal

disinfection

treated

dentin

matrix

fabrication

bleeding

induction

and

placement

of

calcium

enriched

mixture

cement

over

the

blood

clot

c

Follow

up

radiograph

postoperation

d

Follow

up

radiograph

postoperation

d

c


Fig. 2. Case 2. A 68-year-old male with ST elevated myocardial infarction. Angiography after manual thrombus aspiration (A). Resolution of indentation with hugging balloon technique with two small balloons (B). Cross-sectional image of intravascular ultrasonography showing encircling calcification (arrow head) (C) and linear breakage (arrow head) of encircling calcification (D).

Fig

Case

A

old

male

with

ST

elevated

myocardial

infarction

Angiography

after

manual

thrombus

aspiration

A

Resolution

of

indentation

with

hugging

balloon

technique

with

two

small

balloons

B

Cross

sectional

image

of

intravascular

ultrasonography

showing

encircling

calcification

arrow

head

C

and

linear

breakage

arrow

head

of

encircling

calcification

D


Fig 2. A series of edged sagittal X-ray images of the human head obtained with the Canny edge detection methods using threshold values of a 0.8, b 0.4, c 0.2, and d 0.1.

Fig

A

series

of

edged

sagittal

X

ray

images

of

the

human

head

obtained

with

the

Canny

edge

detection

methods

using

threshold

values

of

a

b

c

and

d


Fig. 2. Brain MRI of the proband (A, B) and his nephew (C, D). (A) The T2 weighted image of the proband show bilateral striatal hyperintensities with necrosis. (B) The T1 weighted image of the proband show bilateral hypointensities with necrosis. (C) The T2 weighted image of his nephew shows bilateral putaminal hyperintensities without necrosis. (D) The T1 weighted image of his nephew shows bilateral putaminal hypointensities without necrosis.

Fig

Brain

MRI

of

the

proband

A

B

and

his

nephew

C

D

A

The

weighted

image

of

the

proband

show

bilateral

striatal

hyperintensities

with

necrosis

B

The

weighted

image

of

the

proband

show

bilateral

hypointensities

with

necrosis

C

The

weighted

image

of

his

nephew

shows

bilateral

putaminal

hyperintensities

without

necrosis

D

The

weighted

image

of

his

nephew

shows

bilateral

putaminal

hypointensities

without

necrosis


Figure 5. Group analysis of sign. (Upper half) SPMs of average neural activity within each group, deaf on the left and hearing on the right, during the sign-word discrimination and non-discrimination tasks compared with the rest period. The same format and statistical thresholds are used as in Figure 2. (Lower half) There was more prominent activation in the left PT in deaf subjects than in hearing subjects during the sign-word discrimination/non-discrimination tasks. The focus of activation on a pseudocolor fMRI is superimposed on a high-resolution anatomical MRI in the sagittal (upper left), coronal (upper right) and transaxial (lower left) planes, as indicated by the blue lines that cross at (--62, --20, 4) corresponding to the left PT (Brodmann area 42). The significance level of the activity is indicated by the color bar; this increases as red proceeds to white. The statistical threshold was P \ 0.05, corrected for multiple comparisons at the cluster level. Lower right, percent signal change in the left PT (-- 62, --20, 4) of the deaf (open square) and hearing (closed square) during worddiscrimination and non-discrimination tasks, CLOSED, OPEN and O--C. *, ** and þ indicate P\ 0.001 (two-sample t-test), þþ P 5 0.002 (two-sample t-test), 3 P 5 0.004 and 33 P\ 0.001 (one-sample t-test).

Figure

Group

analysis

of

sign

Upper

half

SPMs

of

average

neural

activity

within

each

group

deaf

on

the

left

and

hearing

on

the

right

during

the

sign

word

discrimination

and

non

discrimination

tasks

compared

with

the

rest

period

The

same

format

and

statistical

thresholds

are

used

as

in

Figure

Lower

half

There

was

more

prominent

activation

in

the

left

PT

in

deaf

subjects

than

in

hearing

subjects

during

the

sign

word

discrimination

non

discrimination

tasks

The

focus

of

activation

on

a

pseudocolor

fMRI

is

superimposed

on

a

high

resolution

anatomical

MRI

in

the

sagittal

upper

left

coronal

upper

right

and

transaxial

lower

left

planes

as

indicated

by

the

blue

lines

that

cross

at

corresponding

to

the

left

PT

Brodmann

area

The

significance

level

of

the

activity

is

indicated

by

the

color

bar

this

increases

as

red

proceeds

to

white

The

statistical

threshold

was

P

corrected

for

multiple

comparisons

at

the

cluster

level

Lower

right

percent

signal

change

in

the

left

PT

of

the

deaf

open

square

and

hearing

closed

square

during

worddiscrimination

and

non

discrimination

tasks

CLOSED

OPEN

and

O

C.

and

þ

indicate

P\

two

sample

t

test

þþ

P

two

sample

t

test

P

and

P\

one

sample

t

test


Figure 2: 63 year old female with gastric infarction. (a) Axial contrast-enhanced CT image demonstrates a distended stomach with gastric pneumatosis (red arrow). A moderate amount of perigastric fluid is noted (red arrowheads). (b) Coronal contrastenhanced CT image demonstrates a distended stomach with gastric pneumatosis (red arrow). Dilated small bowel loops (red open arrows), and a moderate amount of perigastric fluid (red arrowheads) are noted. (c) Sagittal contrast-enhanced CT image demonstrates a distended stomach with gastric pneumatosis (red arrow). Dilated small bowel loops with air-fluid levels (red open arrows) and a moderate amount of perigastric fluid (red arrowheads) are noted. (GE Lightspeed VCT, 120 kVp, 597 mA, 2.5 mm slice thickness, 1.375 pitch, 141 cc Omnipaque 240 IV contrast, portal venous phase)

Figure

year

old

female

with

gastric

infarction

a

Axial

contrast

enhanced

CT

image

demonstrates

a

distended

stomach

with

gastric

pneumatosis

red

arrow

A

moderate

amount

of

perigastric

fluid

is

noted

red

arrowheads

b

Coronal

contrastenhanced

CT

image

demonstrates

a

distended

stomach

with

gastric

pneumatosis

red

arrow

Dilated

small

bowel

loops

red

open

arrows

and

a

moderate

amount

of

perigastric

fluid

red

arrowheads

are

noted

c

Sagittal

contrast

enhanced

CT

image

demonstrates

a

distended

stomach

with

gastric

pneumatosis

red

arrow

Dilated

small

bowel

loops

with

air

fluid

levels

red

open

arrows

and

a

moderate

amount

of

perigastric

fluid

red

arrowheads

are

noted

GE

Lightspeed

VCT

kVp

mA

mm

slice

thickness

pitch

cc

Omnipaque

IV

contrast

portal

venous

phase


Figure 1. Chest radiograph obtained: (A) at admission reveals diffuse miliary shadows and (B) 90 days after tuberculosis treatment.

Figure

Chest

radiograph

obtained

A

at

admission

reveals

diffuse

miliary

shadows

and

B

days

after

tuberculosis

treatment


Figure 1: Axial (T2 weighted; a) and sagittal (T1 weighted; b) MRI image after 3 weeks epidural block through the interlaminar approach at L4–L5. Hyperintense mass on T1‑weighted (white arrow) pushing on anterior aspect of the spinal cord at the L5‑S1 level (white arrow: epidural hematoma). Axial (T2 weighted; c) and sagittal (T1 weighted; d) MRI image after 10 months. The figure shows complete resolution of the hematoma shown in the previous images. MRI: Magnetic resonance imaging.

Figure

Axial

weighted

a

and

sagittal

weighted

b

MRI

image

after

weeks

epidural

block

through

the

interlaminar

approach

at

Hyperintense

mass

on

white

arrow

pushing

on

anterior

aspect

of

the

spinal

cord

at

the

level

white

arrow

epidural

hematoma

Axial

weighted

c

and

sagittal

weighted

d

MRI

image

after

months

The

figure

shows

complete

resolution

of

the

hematoma

shown

in

the

previous

images

MRI

Magnetic

resonance

imaging


Figure 1. A: Annular measurement by cardiac computed tomography scan. The aortic annular size was 17.7 mm in area and 17.9 mm in circumference. B: Three-dimensional CT scan showing the relationship between the thoracotomy and the aortic root, and the difference between the thoracotomies. MIAVR is usually performed from the third intercostal space, so that the aortic valve, the aortotomy and the thoracotomy are located along a straight line. However, in the present case, surgery was performed through a right anterolateral thoracotomy at the fourth intercostal space in consideration of the access to the aortic root. AV indicates aortic valve.

Figure

A

Annular

measurement

by

cardiac

computed

tomography

scan

The

aortic

annular

size

was

mm

in

area

and

mm

in

circumference

B

Three

dimensional

CT

scan

showing

the

relationship

between

the

thoracotomy

and

the

aortic

root

and

the

difference

between

the

thoracotomies

MIAVR

is

usually

performed

from

the

third

intercostal

space

so

that

the

aortic

valve

the

aortotomy

and

the

thoracotomy

are

located

along

a

straight

line

However

in

the

present

case

surgery

was

performed

through

a

right

anterolateral

thoracotomy

at

the

fourth

intercostal

space

in

consideration

of

the

access

to

the

aortic

root

AV

indicates

aortic

valve


Fig. 2. Discrepancy of capsule appearance assessment between readers. Axial contrast-enhanced MRI images in the delayed phase from a 57-year-old man (A) and a 66-year-old woman (B). Axial contrast-enhanced CT images also in the delayed phase from a 64-year-old man (C) and a 68-year-old man (D). All patients had pathologically proven hepatocellular

Fig

Discrepancy

of

capsule

appearance

assessment

between

readers

Axial

contrast

enhanced

MRI

images

in

the

delayed

phase

from

a

old

man

A

and

a

old

woman

B

Axial

contrast

enhanced

CT

images

also

in

the

delayed

phase

from

a

old

man

C

and

a

old

man

D

All

patients

had

pathologically

proven

hepatocellular


Figure 1. (a) A radiograph of the right leg shows a cookie bite at the diaphysis of right proximal tibia indicating an eccentric osteolytic cortical lesion (arrow). (b) Posteroanterior radiograph of the chest shows a soft tissue mass (arrow) in the retrocardiac region of left lower lung.

Figure

a

A

radiograph

of

the

right

leg

shows

a

cookie

bite

at

the

diaphysis

of

right

proximal

tibia

indicating

an

eccentric

osteolytic

cortical

lesion

arrow

b

Posteroanterior

radiograph

of

the

chest

shows

a

soft

tissue

mass

arrow

in

the

retrocardiac

region

of

left

lower

lung


Figure 1 Brain magnetic resonance imaging. (A) and (B) are MRIs taken before the thiamine treatment, while (C) and (D) are from 5 mo after the thiamine treatment. A: Symmetrical high T2 signal intensities in pons; B: Symmetrical high T2 signal intensities in paraventricular area; C: Reduction of abnormal signal in pons; D: Reduction of abnormal signal in paraventricular area. MRI: Magnetic resonance imaging.

Figure

Brain

magnetic

resonance

imaging

A

and

B

are

MRIs

taken

before

the

thiamine

treatment

while

C

and

D

are

from

mo

after

the

thiamine

treatment

A

Symmetrical

high

signal

intensities

in

pons

B

Symmetrical

high

signal

intensities

in

paraventricular

area

C

Reduction

of

abnormal

signal

in

pons

D

Reduction

of

abnormal

signal

in

paraventricular

area

MRI

Magnetic

resonance

imaging


Fig. 4 Patient no. 2, 54-yearold man, presented with left hemiparesthesia and dysarthria after physical exercise. Coronal MIP reconstruction of 3D T1 FS SPACE (a) shows the subacute mural hematoma in the cervical right ICA (black arrowhead). MIP reconstruction of gadoliniumenhanced MR angiography of the head and neck vessels (b) shows a tapering stenosis of the ICA and two distal pseudoaneurysms (white arrow)

Fig

Patient

no

man

presented

with

left

hemiparesthesia

and

dysarthria

after

physical

exercise

Coronal

MIP

reconstruction

of

FS

SPACE

a

shows

the

subacute

mural

hematoma

in

the

cervical

right

ICA

black

arrowhead

MIP

reconstruction

of

gadoliniumenhanced

MR

angiography

of

the

head

and

neck

vessels

b

shows

a

tapering

stenosis

of

the

ICA

and

two

distal

pseudoaneurysms

white

arrow


Figure 2 Ubiquitin C-terminal hydrolase-L1 protein (UCH-L1) and glial fibrillary acidic protein (GFAP) dynamics in human serum after acute injury. (a and b) Computed tomography scans demonstrating focal and diffuse brain injury in individual patients. (c and d) UCH-L1 (green circles) and GFAP (blue triangles) serum concentrations measured every six hours in corresponding individual patients. Time (x axis) reflects interval after injury.

Figure

Ubiquitin

C

terminal

hydrolase

protein

UCH

and

glial

fibrillary

acidic

protein

GFAP

dynamics

in

human

serum

after

acute

injury

a

and

b

Computed

tomography

scans

demonstrating

focal

and

diffuse

brain

injury

in

individual

patients

c

and

d

UCH

green

circles

and

GFAP

blue

triangles

serum

concentrations

measured

every

six

hours

in

corresponding

individual

patients

Time

x

axis

reflects

interval

after

injury


Figure 3 Photomicrographs of parasagittal sections of murine tongue illustrating protection from DXR-induced apoptosis. Mice were orally treated with unrelated antibody (A), or with anti-anthracycline antibody (B–C), and 2 h later i.v. injected with 30 mg/kg of DXR. The tongues were evaluated 4 (A–B) or 24 (C) h later. Bar 100 µm

Figure

Photomicrographs

of

parasagittal

sections

of

murine

tongue

illustrating

protection

from

DXR

induced

apoptosis

Mice

were

orally

treated

with

unrelated

antibody

A

or

with

anti

anthracycline

antibody

B

C

and

h

later

i.v

injected

with

mg

kg

of

DXR

The

tongues

were

evaluated

A

B

or

C

h

later

Bar

µm


Figure 1. Female patient, aged 63 years, with back pain for 3 months, who underwent percutaneous kyphoplasty (PKP). (A–C) Preoperative lateral x-ray and CT scan showed L1 vertebral fracture with vacuum-like changes, MRI showed low signal of the necrotic area on T2-weighted images. (D, E) Postoperative x-ray showed that the cavity of intravertebral cleft was filled with bone cement, and the final follow-up review revealed fine cement position and satisfactory radiographic results.

Figure

Female

patient

aged

years

with

back

pain

for

months

who

underwent

percutaneous

kyphoplasty

PKP

A

C

Preoperative

lateral

x

ray

and

CT

scan

showed

vertebral

fracture

with

vacuum

like

changes

MRI

showed

low

signal

of

the

necrotic

area

on

images

D

E

Postoperative

x

ray

showed

that

the

cavity

of

intravertebral

cleft

was

filled

with

bone

cement

and

the

final

follow

up

review

revealed

fine

cement

position

and

satisfactory

radiographic

results


Figure 4 Longitudinal sections of flowers of Lacandonia brasiliana (LM). (A, B) Longitudinal sections of unopened buds showing central stamens at a pre-meiotic stage, with anther wall layers already visible surrounding sporogenous cells. The carpels have not yet begun to differentiate ovules. Filamentous appendages have begun to grow from the tips of the tepals. (C) Longitudinal section of inflorescence with three unopened buds at different stages, the youngest flower primordium lacking organs. (D) Longitudinal section of later stage; individual pollen grains visible in anther locules; ovules at megaspore mother stage with developing integuments. Filamentous tepal appendages have extended down between the anthers. (E) Transverse section of an apical tepal appendage showing central vasculature. Labels: ca,carpel; fta,filamentous tepal appendage; st,stamen; yp,young flower primordium. Scale bars: in A−D = 100 µm, in E = 10 µm.

Figure

Longitudinal

sections

of

flowers

of

Lacandonia

brasiliana

LM

A

B

Longitudinal

sections

of

unopened

buds

showing

central

stamens

at

a

pre

meiotic

stage

with

anther

wall

layers

already

visible

surrounding

sporogenous

cells

The

carpels

have

not

yet

begun

to

differentiate

ovules

Filamentous

appendages

have

begun

to

grow

from

the

tips

of

the

tepals

C

Longitudinal

section

of

inflorescence

with

three

unopened

buds

at

different

stages

the

youngest

flower

primordium

lacking

organs

D

Longitudinal

section

of

later

stage

individual

pollen

grains

visible

in

anther

locules

ovules

at

megaspore

mother

stage

with

developing

integuments

Filamentous

tepal

appendages

have

extended

down

between

the

anthers

E

Transverse

section

of

an

apical

tepal

appendage

showing

central

vasculature

Labels

ca

carpel

fta

filamentous

tepal

appendage

st

stamen

yp

young

flower

primordium

Scale

bars

in

A−D

µm

in

E

µm


Figure  2: (a) T2 magnetic resonance (MR) weighted images showing the descent of cerebellar tonsils through the foramen magnum and the compression of the medulla oblongata, (b) T2-weighted postoperative MR in sagittal plane demonstrates the repositioning of cerebellar tonsils and the enlargement of subarachnoid spaces of posterior cranial fossa.

Figure

a

magnetic

resonance

MR

weighted

images

showing

the

descent

of

cerebellar

tonsils

through

the

foramen

magnum

and

the

compression

of

the

medulla

oblongata

b

postoperative

MR

in

sagittal

plane

demonstrates

the

repositioning

of

cerebellar

tonsils

and

the

enlargement

of

subarachnoid

spaces

of

posterior

cranial

fossa


Figure 2. Example images illustrating scan quality with the region if interest (ROI) defined around the 65% radius (white dotted line) site: a) Scan with broken cortex (defined as incomplete cortex at one or more points); b) Scan rated 5 according to qualitative analysis 18 ; c) Unanalyzable scan (ROI could not be defined without assumption of bone shape).

Figure

Example

images

illustrating

scan

quality

with

the

region

if

interest

ROI

defined

around

the

radius

white

dotted

line

site

a

Scan

with

broken

cortex

defined

as

incomplete

cortex

at

one

or

more

points

b

Scan

rated

according

to

qualitative

analysis

c

Unanalyzable

scan

ROI

could

not

be

defined

without

assumption

of

bone

shape


Figure 2. Immunohistochemical localization of nuclear factor of activated T cells (NFAT) in rat testes. Asterisks indicate Leydig cells that were positively stained for NFAT. (A): NFAT2 expression in Leydig cells. (B): NFAT2 immunostainings were abolished by incubating with Phosphate-buffered saline (PBS) buffer instead of anti-NFAT antibody. Scale bar = 50 μm.

Figure

Immunohistochemical

localization

of

nuclear

factor

of

activated

T

cells

NFAT

in

rat

testes

Asterisks

indicate

Leydig

cells

that

were

positively

stained

for

NFAT

A

expression

in

Leydig

cells

B

immunostainings

were

abolished

by

incubating

with

Phosphate

buffered

saline

PBS

buffer

instead

of

anti

NFAT

antibody

Scale

bar

μm


Figure 2. Histology of the biopsy specimens. (A) A biopsy specimen of the duodenum with dilated villi. (B) Aggregation of foamy macrophages in the lamina propria. (C) Diastase-resistant-positive particles found in the cytoplasm of foamy macrophages. (D) High magnification of a PAS stain (D), a Warthin-Starry stain (E) and an acid-fast stain (F). (G-H) Histology of the biopsy specimens of the duodenum obtained during the follow-up endoscopic examination performed three months after treatment. (G) Duodenal mucosa with slightly swollen villi. (H) Diastase-resistant PAS-positive particles remaining in the cytoplasm of foamy macrophages. (Original magnification; A: ×10. B, C: ×100. D-F: ×400. G: ×40. H: ×100)

Figure

Histology

of

the

biopsy

specimens

A

A

biopsy

specimen

of

the

duodenum

with

dilated

villi

B

Aggregation

of

foamy

macrophages

in

the

lamina

propria

C

Diastase

resistant

positive

particles

found

in

the

cytoplasm

of

foamy

macrophages

D

High

magnification

of

a

PAS

stain

D

a

Warthin

Starry

stain

E

and

an

acid

fast

stain

F

G

H

Histology

of

the

biopsy

specimens

of

the

duodenum

obtained

during

the

follow

up

endoscopic

examination

performed

three

months

after

treatment

G

Duodenal

mucosa

with

slightly

swollen

villi

H

Diastase

resistant

PAS

positive

particles

remaining

in

the

cytoplasm

of

foamy

macrophages

Original

magnification

A

B

C

D

F

G

H


Figure 3 Direct cholangioscopy with the enteroscope showed a lar direct visualization using a retrieval balloon (B).

Figure

Direct

cholangioscopy

with

the

enteroscope

showed

a

lar

direct

visualization

using

a

retrieval

balloon

B


Fig. 4. Fate of mouse crest cells transplanted in ovo. (A) Macroscopic view of a mouse/chick chimera examined 3.5 days after implantation (10- somite stage) at unsegmented plate level with 9 dpc Rosa 26 mouse caudal neural tube. Mouse neural tube cells and their derivatives (arrows) expressing β-galactosidase are identified by LacZ staining. Transverse section of a mouse/chick chimera examined 4 days after implantation (17-somite stage) at the 13-17 somite level with 9 dpc mouse caudal neural tube. (B) Neurofilament immunostaining. Note the positive nerves emerging from the implanted tube (arrow). (C) Mouse neural crest-derived cells are observed along neurofilament positive nerves (arrows).

Fig

Fate

of

mouse

crest

cells

transplanted

in

ovo

A

Macroscopic

view

of

a

mouse

chick

chimera

examined

days

after

implantation

somite

stage

at

unsegmented

plate

level

with

dpc

Rosa

mouse

caudal

neural

tube

Mouse

neural

tube

cells

and

their

derivatives

arrows

expressing

β

galactosidase

are

identified

by

LacZ

staining

Transverse

section

of

a

mouse

chick

chimera

examined

days

after

implantation

stage

at

the

somite

level

with

dpc

mouse

caudal

neural

tube

B

Neurofilament

immunostaining

Note

the

positive

nerves

emerging

from

the

implanted

tube

arrow

C

Mouse

neural

crest

derived

cells

are

observed

along

neurofilament

positive

nerves

arrows


Figure 1. Axial fluid attenuated inversion recovery magnetic resonance imaging scan (top) and sagittal reconstruction T2-weighted magnetic resonance imaging scan (bottom) show an area of increased signal consistent with an ischemic stroke in the left paramedian dorsal pontine tegmentum, adjacent to the fourth ventricle.

Figure

Axial

fluid

attenuated

inversion

recovery

magnetic

resonance

imaging

scan

top

and

sagittal

reconstruction

magnetic

resonance

imaging

scan

bottom

show

an

area

of

increased

signal

consistent

with

an

ischemic

stroke

in

the

left

paramedian

dorsal

pontine

tegmentum

adjacent

to

the

fourth

ventricle


Figure 4. Coronal (A) and sagittal (B) post-contrast magnetic resonance images 16 months after the cerebrospinal fluid (CSF) leak repair show resolution of the dural enhancement and subdural hygromas seen in Figure 1 (C-D). Note the presence of a vascularized septal flap (arrow, B) and return of the brainstem and cerebellum to a normal anatomic position in comparison to the inferior displacement noted in Figure 1 (D). These findings indicate full resolution of intracranial hypotension caused by the CSF leak.

Figure

Coronal

A

and

sagittal

B

post

contrast

magnetic

resonance

images

months

after

the

cerebrospinal

fluid

CSF

leak

repair

show

resolution

of

the

dural

enhancement

and

subdural

hygromas

seen

in

Figure

C

D

Note

the

presence

of

a

vascularized

septal

flap

arrow

B

and

return

of

the

brainstem

and

cerebellum

to

a

normal

anatomic

position

in

comparison

to

the

inferior

displacement

noted

in

Figure

D

These

findings

indicate

full

resolution

of

intracranial

hypotension

caused

by

the

CSF

leak


Figure 2: Airway reconstructions from the chest CT. (A) Anterioposterior view of the trachea: a significant compression at the distal trachea (C: carina; T: trachea; white asteroid: external compression of the trachea). (B) Lateral view of the trachea: the compression from the posterior of the trachea (C: carina; O: oesophagus T: trachea; white asteroid: external compression of the trachea).

Figure

Airway

reconstructions

from

the

chest

CT

A

Anterioposterior

view

of

the

trachea

a

significant

compression

at

the

distal

trachea

C

carina

T

trachea

white

asteroid

external

compression

of

the

trachea

B

Lateral

view

of

the

trachea

the

compression

from

the

posterior

of

the

trachea

C

carina

O

oesophagus

T

trachea

white

asteroid

external

compression

of

the

trachea


Figure 2. Brain digital subtraction angiography at admission revealed a remarkab artery (A). Eleven days following anti-platelet treatment, the repeated brain CT show Repeated DSA (C) showed that the angiostenosis in the middle cerebral artery wa

Figure

Brain

digital

subtraction

angiography

at

admission

revealed

a

remarkab

artery

A

Eleven

days

following

anti

platelet

treatment

the

repeated

brain

CT

show

Repeated

DSA

C

showed

that

the

angiostenosis

in

the

middle

cerebral

artery

wa


Figure 2. Technetium (99mTc)-sestamibi scan. (A) A 15-minute scan after 99mTc-sestamibi injection shows normal thyroid uptake. (B) A 2-hour scan after 99mTc-sestamibi injection shows no parathyroid uptake.

Figure

Technetium

scan

A

A

scan

after

sestamibi

injection

shows

normal

thyroid

uptake

B

A

scan

after

sestamibi

injection

shows

no

parathyroid

uptake


Fig. 2 Chest x-ray after fibrin glue injection. Chest x-ray at 30 min (a) and 12 h (b) after fibrin glue injection. A minimal PTX was appreciable in (a) and disappeared in (b). At the distal tip of the chest tube is visible a radiopaque area referable to the fibrin glue clot more evident in (b) than in (a)

Fig

Chest

x

ray

after

fibrin

glue

injection

Chest

x

ray

at

min

a

and

h

b

after

fibrin

glue

injection

A

minimal

PTX

was

appreciable

in

a

and

disappeared

in

b

At

the

distal

tip

of

the

chest

tube

is

visible

a

radiopaque

area

referable

to

the

fibrin

glue

clot

more

evident

in

b

than

in

a


Fig. 8. (a) Three reconstructed surfaces displayed on an axial slice of the original MR data. (b) A zoom of the bottom-right corner of (a). (c), (d) Zoomed views on coronal and sagittal slices, respectively. Yellow: inner; blue: central; red: pial.

Fig

a

Three

reconstructed

surfaces

displayed

on

an

axial

slice

of

the

original

MR

data

b

A

zoom

of

the

bottom

right

corner

of

a

c

d

Zoomed

views

on

coronal

and

sagittal

slices

respectively

Yellow

inner

blue

central

red

pial


Figure 1. A: Chest HRCT scan in January 2001, showing a nodular shadow in the cavity lesion in the right S3, and reticulonodular, cystic, and ground-grass opacities in the bilateral lung fields, predominantly in the subpleural areas with honeycombing in the bilateral lower zones. B: Chest HRCT scan in September 2002, showing exacerbation of the opacities.

Figure

A

Chest

HRCT

scan

in

January

showing

a

nodular

shadow

in

the

cavity

lesion

in

the

right

and

reticulonodular

cystic

and

ground

grass

opacities

in

the

bilateral

lung

fields

predominantly

in

the

subpleural

areas

with

honeycombing

in

the

bilateral

lower

zones

B

Chest

HRCT

scan

in

September

showing

exacerbation

of

the

opacities


Fig. 1. CT images of healthy lung tissue biopsies. (A) Healthy lung before biopsy. (B) Lung image after injection of 2–3 ml stroke-physiological saline solution. (C) CT-guided biopsy. White arrow = syringe, black arrow = exudative area after injecting 2–3 ml strokephysiological saline solution, white arrowhead = core needle.

Fig

CT

images

of

healthy

lung

tissue

biopsies

A

Healthy

lung

before

biopsy

B

Lung

image

after

injection

of

ml

stroke

physiological

saline

solution

C

CT

guided

biopsy

White

arrow

syringe

black

arrow

exudative

area

after

injecting

ml

strokephysiological

saline

solution

white

arrowhead

core

needle


Fig. 3. Sonograms of equine superficial gluteal muscle at D0, D2 and D7 moments. (A) D0. Region that did not received UC-MSCs/HBSS injection. Note the arrangement of the muscle fibers of a healthy tissue. (B) Needle image (yellow arrow) being guided by ultrasound at a depth of about 2 cm. (C) D2. Muscles with heterogeneous aspect (red ellipse) and presence of hypo echogenic regions (yellow arrow), after UC-MSCs injection. (D) D7. Improved aspect of the muscles with the presence of discrete hypoechoic regions permeated at the muscle fibers (red ellipse).

Fig

Sonograms

of

equine

superficial

gluteal

muscle

at

and

moments

A

Region

that

did

not

received

UC

MSCs

HBSS

injection

Note

the

arrangement

of

the

muscle

fibers

of

a

healthy

tissue

B

Needle

image

yellow

arrow

being

guided

by

ultrasound

at

a

depth

of

about

cm

C

Muscles

with

heterogeneous

aspect

red

ellipse

and

presence

of

hypo

echogenic

regions

yellow

arrow

after

UC

MSCs

injection

D

Improved

aspect

of

the

muscles

with

the

presence

of

discrete

hypoechoic

regions

permeated

at

the

muscle

fibers

red

ellipse


Figure 1: Immature Teratoma Ultrasound (US) and Macroscopic Finding Durante Operation. CASE 1: A. US showed hypohyperechoic left adnexal mass which cannot reach totally inside probe range at 19w5d GA, irregular border, unsmooth surface; B. uterine size appropriate with 18-20 weeks GA, left Fallopian tube was normal, post-oophorectomy; and C. Lobulated solid mass with internal multiseptal cystic mass

Figure

Immature

Teratoma

Ultrasound

US

and

Macroscopic

Finding

Durante

Operation

CASE

A.

US

showed

hypohyperechoic

left

adnexal

mass

which

can

not

reach

totally

inside

probe

range

at

GA

irregular

border

unsmooth

surface

B.

uterine

size

appropriate

with

weeks

GA

left

Fallopian

tube

was

normal

post

oophorectomy

and

C.

Lobulated

solid

mass

with

internal

multiseptal

cystic

mass


Figure 1. A male, 36-year-old patient. Non contrast-enhanced axial CT image (A) showing spontaneously hyperdense lesion located in the Monro´s foramen and in the anterior portion of the third ventricle, determining left lateral ventricle ectasia. Coronal (B) MRI and contrastenhanced, axial T1-weighted image (C) demonstrate the presence of a solid lesion with no apparent contrast uptake. On axial T2-weighted images (D) the lesion presents with isosignal. anatomopathological study revealed colloid cyst.

Figure

A

male

old

patient

Non

contrast

enhanced

axial

CT

image

A

showing

spontaneously

hyperdense

lesion

located

in

the

Monro´s

foramen

and

in

the

anterior

portion

of

the

third

ventricle

determining

left

lateral

ventricle

ectasia

Coronal

B

MRI

and

contrastenhanced

axial

image

C

demonstrate

the

presence

of

a

solid

lesion

with

no

apparent

contrast

uptake

On

axial

images

D

the

lesion

presents

with

isosignal

anatomopathological

study

revealed

colloid

cyst


Fig. 1. Regions of interest for optic radiation tractography. (A) Seed regions of interest were defined on an axial slice and positioned immediately lateral to the lateral geniculate nuclei within the white matter of the optic radiations at the apex of the arc around the lateral ventricles. (B) Target regions of interest were placed on a coronal slice, designed to encompass the entire white matter cross-section of the optic radiations as they passed into the primary visual cortices. (C) Optic radiation white matter tracts of a very preterm 7-year-old. (D), (E), (F) Locations of the anterior, middle and posterior sub-regions of the optic radiations respectively.

Fig

Regions

of

interest

for

optic

radiation

tractography

A

Seed

regions

of

interest

were

defined

on

an

axial

slice

and

positioned

immediately

lateral

to

the

lateral

geniculate

nuclei

within

the

white

matter

of

the

optic

radiations

at

the

apex

of

the

arc

around

the

lateral

ventricles

B

Target

regions

of

interest

were

placed

on

a

coronal

slice

designed

to

encompass

the

entire

white

matter

cross

section

of

the

optic

radiations

as

they

passed

into

the

primary

visual

cortices

C

Optic

radiation

white

matter

tracts

of

a

very

preterm

old

D

E

F

Locations

of

the

anterior

middle

and

posterior

sub

regions

of

the

optic

radiations

respectively


Figure 1. (a) Pinhole-like opening in the mucosal region with scar and convergence of intestinal folds observed at the front of the endoscope. (b) No pancreatic calculi or recurrence of intraductal papillary mucinous neoplasm was noted. (c) The anastomotic site was dilated to 3 mm at 6 atm using a 4 mm balloon dilator. (d) A 5 Fr pancreatic stent was inserted.

Figure

a

Pinhole

like

opening

in

the

mucosal

region

with

scar

and

convergence

of

intestinal

folds

observed

at

the

front

of

the

endoscope

b

No

pancreatic

calculi

or

recurrence

of

intraductal

papillary

mucinous

neoplasm

was

noted

c

The

anastomotic

site

was

dilated

to

mm

at

atm

using

a

mm

balloon

dilator

d

A

Fr

pancreatic

stent

was

inserted


Figure 2 (A): Non-contrast computed tomography of kidney, ureter and bladder (axial section) showing replacement of entire left kidney with calcification. (B): Contrast film showing non-functioning left kidney with normal contrast uptake by right kidney (coronal section).

Figure

A

Non

contrast

computed

tomography

of

kidney

ureter

and

bladder

axial

section

showing

replacement

of

entire

left

kidney

with

calcification

B

Contrast

film

showing

non

functioning

left

kidney

with

normal

contrast

uptake

by

right

kidney

coronal

section


Fig. 1 Photodocumentation of pretreatment phase of one patient (case 1). a Fundus photography showing a satellite lesion (yellow square) of activ‑ ity suggestive of retinochoroiditis toxoplasmosis in the macula region and a healed retinochoroiditis lesion (blue circle); b fluorescein angiography showing a satellite lesion suggestive of activity of toxoplasmosis (yellow rectangle) in the macula region and a healed retinochoroiditis lesion (blue circle); c increases in the thickness of the inner retinal layers in perimacular regions (arrows) seen by optical coherence tomography

Fig

Photodocumentation

of

pretreatment

phase

of

one

patient

case

a

Fundus

photography

showing

a

satellite

lesion

yellow

square

of

activ‑

ity

suggestive

of

retinochoroiditis

toxoplasmosis

in

the

macula

region

and

a

healed

retinochoroiditis

lesion

blue

circle

b

fluorescein

angiography

showing

a

satellite

lesion

suggestive

of

activity

of

toxoplasmosis

yellow

rectangle

in

the

macula

region

and

a

healed

retinochoroiditis

lesion

blue

circle

c

increases

in

the

thickness

of

the

inner

retinal

layers

in

perimacular

regions

arrows

seen

by

optical

coherence

tomography


Figure 3 Ki-67 nuclear expression in different groups. Notes: Most of the nuclei showed Ki-67 nuclear immunoreactivity in control and sildenafil-treated tumors (A and B). Nuclei of cisplatin-treated tumors and tumors treated with the combination therapy showed markedly reduced nuclear Ki-67 positivity (C and D). Magnification, (A and B) ×200; (C) ×400; and (D) ×100. nuclear positivity is shown by arrows.

Figure

nuclear

expression

in

different

groups

Notes

Most

of

the

nuclei

showed

nuclear

immunoreactivity

in

control

and

sildenafil

treated

tumors

A

and

B

Nuclei

of

cisplatin

treated

tumors

and

tumors

treated

with

the

combination

therapy

showed

markedly

reduced

nuclear

positivity

C

and

D

Magnification

A

and

B

C

and

D

nuclear

positivity

is

shown

by

arrows


Figure 1: Poorly-differentiated squamous cell carcinoma lacking clear evidence of squamous differentiation (hematoxylin and eosin) (a). In the oropharynx, these are typically HPV-associated neoplasms. Immunohistochemical stain demonstrates diffuse nuclear and cytoplasmic staining for p16 (b), while in situ hybridization highlights the presence of HPV DNA.

Figure

Poorly

differentiated

squamous

cell

carcinoma

lacking

clear

evidence

of

squamous

differentiation

hematoxylin

and

eosin

a

In

the

oropharynx

these

are

typically

HPV

associated

neoplasms

Immunohistochemical

stain

demonstrates

diffuse

nuclear

and

cytoplasmic

staining

for

b

while

in

situ

hybridization

highlights

the

presence

of

HPV

DNA


Fig. 3 a, b Ewing sarcoma of the liver in a 10-year-old boy. a Axial abdominal CT shows a large, predominantly hypodense tumor involving the right lobe. The inferior vena cava (arrows) is compressed and displaced by the tumor and appears elongated in the anteroposterior direction. b Coronal reformatted abdominal CT image shows the spatial relationship between the tumor and adjacent structures such as the inferior vena cava (asterisks) and right kidney (arrows)

Fig

a

b

Ewing

sarcoma

of

the

liver

in

a

old

boy

a

Axial

abdominal

CT

shows

a

large

predominantly

hypodense

tumor

involving

the

right

lobe

The

inferior

vena

cava

arrows

is

compressed

and

displaced

by

the

tumor

and

appears

elongated

in

the

anteroposterior

direction

b

Coronal

reformatted

abdominal

CT

image

shows

the

spatial

relationship

between

the

tumor

and

adjacent

structures

such

as

the

inferior

vena

cava

asterisks

and

right

kidney

arrows


Figure 8. Micro-computed tomography images of the cross-section of the magnesium pin (week 36). (A) Maximum inner diameter of the new bone loop (orange line, 2.34 mm) and (B) Diameter of the pin (orange line, 1.94 mm) at the same position. Red arrows indicate the magnesium-alloy pin and the yellow arrow indicates bone formation around the pin.

Figure

Micro

computed

tomography

images

of

the

cross

section

of

the

magnesium

pin

week

A

Maximum

inner

diameter

of

the

new

bone

loop

orange

line

mm

and

B

Diameter

of

the

pin

orange

line

mm

at

the

same

position

Red

arrows

indicate

the

magnesium

alloy

pin

and

the

yellow

arrow

indicates

bone

formation

around

the

pin


FIG. 2. Sarcomeric organization of RyR clusters in developing mouse diaphragm. Immunofluorescence labeling of RyRs shows the first yR clusters at E15 at or close to the periphery of individual myotubes (arrows, A). Some clusters are also present internally (double arrows) ut show no regular organization. At E16, strings of RyRs clusters are detected throughout the myotubes (B). In some areas, the clusters re in doublets (double arrows) that have a two-per-sarcomere spacing and are transversely aligned across several adjacent myofibrillar undles. However, a less ordered arrangement is also often seen at this age. At E17, the majority of RyR clusters are arranged in doublets nd in obvious transverse bands (C). While this general arrangement persists throughout development, the doublets of RyR clusters become ore discrete, denser, and better aligned with age (D–F). Small areas of disorder are common at E17, but become scarce at E18 (D) and are irtually absent at later stages (E, F). Occasional jumps in the cross alignment of RyR spots indicate that they follow the myofibrils’ banding attern.

FIG

Sarcomeric

organization

of

RyR

clusters

in

developing

mouse

diaphragm

Immunofluorescence

labeling

of

RyRs

shows

the

first

yR

clusters

at

at

or

close

to

the

periphery

of

individual

myotubes

arrows

A

Some

clusters

are

also

present

internally

double

arrows

ut

show

no

regular

organization

At

strings

of

RyRs

clusters

are

detected

throughout

the

myotubes

B

In

some

areas

the

clusters

re

in

doublets

double

arrows

that

have

a

two

per

sarcomere

spacing

and

are

transversely

aligned

across

several

adjacent

myofibrillar

undles

However

a

less

ordered

arrangement

is

also

often

seen

at

this

age

At

the

majority

of

RyR

clusters

are

arranged

in

doublets

nd

in

obvious

transverse

bands

C

While

this

general

arrangement

persists

throughout

development

the

doublets

of

RyR

clusters

become

ore

discrete

denser

and

better

aligned

with

age

D

F

Small

areas

of

disorder

are

common

at

but

become

scarce

at

D

and

are

irtually

absent

at

later

stages

E

F

Occasional

jumps

in

the

cross

alignment

of

RyR

spots

indicate

that

they

follow

the

myofibrils

banding

attern


FIG. 3. Color online Anatomopathological findings in asbestos related diseases. A Chest x ray in the case of asbestosis benign disease with plaques on diaphragmatic and mediastinal pleura. Pleural plaques are localized scars fibrosis consisting of collagen fiber deposits that form as a result of exposure to asbestos. They are the most common manifestation of exposure to asbestos. Normally, pleural plaque is found in the parietal pleura on the inside of the diaphragm , but in very rare cases, they can also be found near the ribcage. Asbestosis is a chronic inflammatory and fibrotic medical condition affecting the parenchymal tissue of the lungs caused by the inhalation and retention of asbestos fibers. It specifically refers to interstitial parenchymal fibrosis from asbestos, and not pleural fibrosis or plaguing. B Asbestos bodies found in sputum. Asbestos bodies are constituted of a central asbestos fiber surrounded by a lining of iron and proteins, which is often segmented. They have a median width of 2.5 m and a median length of 20–50 m and generally have a straight shape. C and D Thoracic CT scan—trasversal C and coronal D sections in MPM, showing the thickening of both parietal and visceral pleural layers. E and F Proliferative epithelioid mesothelioma, chest x rays E and the corresponding thoracoscopy view F ; black arrow → indicates malignant areas, while the white one ⇒ denotes an isolated hyaline plate. Hyaline pleural plaques generally occur as discrete elevated gray-white areas, usually involving the parietal layer and without associated effusions or adhesions. They are composed of laminated hyaline collagen; there is no suggestion of vasculature or granulation. They are usually detected in the case of asbestos exposure. Thoracoscopy is a medical procedure involving internal examination, biopsy, and/or resection of disease or masses within the pleural cavity and thoracic cavity. It is the golden standard procedure for MPM diagnosis. Courtesy of E. Pozzi and P. Cremaschi, Cardio-Thoraco Vascular Dept., Section of Pneumology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

FIG

Color

online

Anatomopathological

findings

in

asbestos

related

diseases

A

Chest

x

ray

in

the

case

of

asbestosis

benign

disease

with

plaques

on

diaphragmatic

and

mediastinal

pleura

Pleural

plaques

are

localized

scars

fibrosis

consisting

of

collagen

fiber

deposits

that

form

as

a

result

of

exposure

to

asbestos

They

are

the

most

common

manifestation

of

exposure

to

asbestos

Normally

pleural

plaque

is

found

in

the

parietal

pleura

on

the

inside

of

the

diaphragm

but

in

very

rare

cases

they

can

also

be

found

near

the

ribcage

Asbestosis

is

a

chronic

inflammatory

and

fibrotic

medical

condition

affecting

the

parenchymal

tissue

of

the

lungs

caused

by

the

inhalation

and

retention

of

asbestos

fibers

It

specifically

refers

to

interstitial

parenchymal

fibrosis

from

asbestos

and

not

pleural

fibrosis

or

plaguing

B

Asbestos

bodies

found

in

sputum

Asbestos

bodies

are

constituted

of

a

central

asbestos

fiber

surrounded

by

a

lining

of

iron

and

proteins

which

is

often

segmented

They

have

a

median

width

of

m

and

a

median

length

of

m

and

generally

have

a

straight

shape

C

and

D

Thoracic

CT

scan

trasversal

C

and

coronal

D

sections

in

MPM

showing

the

thickening

of

both

parietal

and

visceral

pleural

layers

E

and

F

Proliferative

epithelioid

mesothelioma

chest

x

rays

E

and

the

corresponding

thoracoscopy

view

F

black

arrow

indicates

malignant

areas

while

the

white

one

denotes

an

isolated

hyaline

plate

Hyaline

pleural

plaques

generally

occur

as

discrete

elevated

gray

white

areas

usually

involving

the

parietal

layer

and

without

associated

effusions

or

adhesions

They

are

composed

of

laminated

hyaline

collagen

there

is

no

suggestion

of

vasculature

or

granulation

They

are

usually

detected

in

the

case

of

asbestos

exposure

Thoracoscopy

is

a

medical

procedure

involving

internal

examination

biopsy

and/or

resection

of

disease

or

masses

within

the

pleural

cavity

and

thoracic

cavity

It

is

the

golden

standard

procedure

for

MPM

diagnosis

Courtesy

of

E.

Pozzi

and

P.

Cremaschi

Cardio

Thoraco

Vascular

Dept

Section

of

Pneumology

Fondazione

IRCCS

Policlinico

San

Matteo

Pavia

Italy


Fig. 1 Example of radiographic response in a patient given poly-ICLC. Left: Axial T1 postcontrast MRI of the patient while on-study. Right: Axial T1 post-contrast image after four cycles of poly-ICLC indicating partial response to therapy

Fig

Example

of

radiographic

response

in

a

patient

given

poly

ICLC

Left

Axial

postcontrast

MRI

of

the

patient

while

on

study

Right

Axial

post

contrast

image

after

four

cycles

of

poly

ICLC

indicating

partial

response

to

therapy


Fig. 2 a Seven months after extraction of tooth #47, a panoramic radiograph showed new bone formation at the equivalent site of teeth #48 and #47 and a radiolucent region around the distal root of tooth #46. b, c Computed tomography showed continuous absorption from the alveolar bone of the distal root of tooth #46 to the lingual cortical bone at the equivalent of tooth #47 and some granulated hard tissues existing inside and outside the mandible (arrow). d Magnetic resonance imaging showed high intensity of the right lower molar region on an enhanced T2-weighted image (arrow). e The soft tissue located between interior to the mandibular angle and anterior to the submandibular gland was enhanced heterogeneously by gadolinium on magnetic resonance imaging (arrow). SM submandibular gland

Fig

a

Seven

months

after

extraction

of

tooth

a

panoramic

radiograph

showed

new

bone

formation

at

the

equivalent

site

of

teeth

and

and

a

radiolucent

region

around

the

distal

root

of

tooth

b

c

Computed

tomography

showed

continuous

absorption

from

the

alveolar

bone

of

the

distal

root

of

tooth

to

the

lingual

cortical

bone

at

the

equivalent

of

tooth

and

some

granulated

hard

tissues

existing

inside

and

outside

the

mandible

arrow

d

Magnetic

resonance

imaging

showed

high

intensity

of

the

right

lower

molar

region

on

an

enhanced

image

arrow

e

The

soft

tissue

located

between

interior

to

the

mandibular

angle

and

anterior

to

the

submandibular

gland

was

enhanced

heterogeneously

by

gadolinium

on

magnetic

resonance

imaging

arrow

SM

submandibular

gland


Figure 3. In vivo assessment of renal perfusion by MRI 3 weeks following RAS surgery. (a) Representative axial cross sectional MR image of the stenotic and contralateral kidney. (b) Representative perfusion map of renal cortex and medulla. (c) Assessment of renal perfusion at baseline and following RAS surgery. (‘B’ = baseline measurement prior to surgery, ‘RAS’ = renal perfusion measurement at 3 weeks after surgery). *p = 0.01.

Figure

In

vivo

assessment

of

renal

perfusion

by

MRI

weeks

following

RAS

surgery

a

Representative

axial

cross

sectional

MR

image

of

the

stenotic

and

contralateral

kidney

b

Representative

perfusion

map

of

renal

cortex

and

medulla

c

Assessment

of

renal

perfusion

at

baseline

and

following

RAS

surgery

B

baseline

measurement

prior

to

surgery

RAS

renal

perfusion

measurement

at

weeks

after

surgery

p


Figure 1. Magnetic resonance images of the thalamus representing 3 orthogonal orientations displayed with MEASURE software. A, Coronal plane; B, sagittal plane; and C, horizontal plane. Grid points falling within the anatomic boundaries of the thalamus are black instead of white.

Figure

Magnetic

resonance

images

of

the

thalamus

representing

orthogonal

orientations

displayed

with

MEASURE

software

A

Coronal

plane

B

sagittal

plane

and

C

horizontal

plane

Grid

points

falling

within

the

anatomic

boundaries

of

the

thalamus

are

black

instead

of

white


Fig 1. A segmental upper lobe consolidation: a) Chest X ray reveals an opacity in the right upper lobe (well delimited by horizontal fissure); b) Ultrasound performed at the level of the axilla shows a “tissular” pattern of the consolidated segment with vessels inside. In depth there is an irregular border (shred sign), the transition between consolidation and the normal aerated lung

Fig

A

segmental

upper

lobe

consolidation

a

Chest

X

ray

reveals

an

opacity

in

the

right

upper

lobe

well

delimited

by

horizontal

fissure

b

Ultrasound

performed

at

the

level

of

the

axilla

shows

a

tissular

pattern

of

the

consolidated

segment

with

vessels

inside

In

depth

there

is

an

irregular

border

shred

sign

the

transition

between

consolidation

and

the

normal

aerated

lung