Figure 4 – Thoracic radiography with distended intestinal loops on the upper abdomen (A); Abdominal echography with distended intestinal loops and slight amount of inter-loops liquid (B).

Figure

Thoracic

radiography

with

distended

intestinal

loops

on

the

upper

abdomen

A

Abdominal

echography

with

distended

intestinal

loops

and

slight

amount

of

inter

loops

liquid

B


Figure 1. a) A retroflex view of the stomach shows edematous and hypertrophic mucosa with reddened giant folds covered with thick mucus. b) Mucosa of the gastric antrum shows reddened hypertrophic mucosa with granular changes. c) Narrow-band imaging (NBI) of the mucosa of the cardia shows hypertrophic mucosa. d) Magnification with NBI of the mucosa in the yellow square of (c) shows enlarged marginal crypt epithelium of variable size and shape. e) NBI of mucosa of the antrum shows granular changes with multiple brownish areas. f) Magnification with NBI of the mucosa in the green square of (e) shows enlarged marginal crypt epithelia of variable size and shape, findings similar to those in the gastric body.

Figure

a

A

retroflex

view

of

the

stomach

shows

edematous

and

hypertrophic

mucosa

with

reddened

giant

folds

covered

with

thick

mucus

b

Mucosa

of

the

gastric

antrum

shows

reddened

hypertrophic

mucosa

with

granular

changes

c

Narrow

band

imaging

NBI

of

the

mucosa

of

the

cardia

shows

hypertrophic

mucosa

d

Magnification

with

NBI

of

the

mucosa

in

the

yellow

square

of

c

shows

enlarged

marginal

crypt

epithelium

of

variable

size

and

shape

e

NBI

of

mucosa

of

the

antrum

shows

granular

changes

with

multiple

brownish

areas

f

Magnification

with

NBI

of

the

mucosa

in

the

green

square

of

e

shows

enlarged

marginal

crypt

epithelia

of

variable

size

and

shape

findings

similar

to

those

in

the

gastric

body


Fig 1. Representative images of a focal lesion (FL) in left pelvis showing changes after 8 weeks. A FL (red arrow) on (A) pre-contrast fat-only, (B) pre-contrast water-only, (C) post-contrast water only mDixon and (D) b1000 diffusion weighted imaging at baseline (A1–D1) and 8 weeks (A2–D2) in a patient who achieved very good partial response (VGPR) after induction chemotherapy. Estimated tumour volume (eTV), signal fat fraction (sFF), enhancement ratio (ER) and apparent diffusion coefficient (ADC) were 4 5 cm3, 0 11 a.u., 167 8% and 1 13 9 10 3 mm2/s at baseline, respectively. At 8 weeks after starting chemotherapy, eTV, sFF, ER and ADC were 3 96 cm3, 0 23 a.u., 197 5% and 1 97 9 10 3 mm2/s, representing a 12% reduction in eTV, 109% increase in sFF, 17 6% increase in ER and 74 3% increase in ADC. [Colour figure can be viewed at wileyonlinelibrary.com].

Fig

Representative

images

of

a

focal

lesion

FL

in

left

pelvis

showing

changes

after

weeks

A

FL

red

arrow

on

A

pre

contrast

fat

only

B

pre

contrast

water

only

C

post

contrast

water

only

mDixon

and

D

diffusion

weighted

imaging

at

baseline

and

weeks

in

a

patient

who

achieved

very

good

partial

response

VGPR

after

induction

chemotherapy

Estimated

tumour

volume

eTV

signal

fat

fraction

sFF

enhancement

ratio

ER

and

apparent

diffusion

coefficient

ADC

were

a.u

and

s

at

baseline

respectively

At

weeks

after

starting

chemotherapy

eTV

sFF

ER

and

ADC

were

a.u

and

s

representing

a

reduction

in

eTV

increase

in

sFF

increase

in

ER

and

increase

in

ADC

Colour

figure

can

be

viewed

at

wileyonlinelibrary.com


Figure 2. CT finding at recurrence and terminal stage. (A) Chest CT indicates the lung metastases at pretreatment with bevacizumab and paclitaxel. (B) Brain CT at terminal stage indicated meningeal metastasis.

Figure

CT

finding

at

recurrence

and

terminal

stage

A

Chest

CT

indicates

the

lung

metastases

at

pretreatment

with

bevacizumab

and

paclitaxel

B

Brain

CT

at

terminal

stage

indicated

meningeal

metastasis


Fig. 2. Pre-operative non-contrast CT and fluoroscopic images of Patient 2. (a). Right ureter (straight arrow) displaced anteriorly from the psoas muscle (*) at the level of L4–L5. Compare this to the normally positioned left ureter (curved arrow) in close proximity to the psoas muscle (*). (b) Right ureter (straight arrow) in the inguinal hernia. (c) Anterograde nephrostogram with the patient in prone position at the time of nephrostomy tube insertion. The right ureter loops below the level of the pubic symphysis into a large right inguinal hernia (one arrow) with evidence of obstruction at the level of the ureterovesical junction (two arrows).

Fig

Pre

operative

non

contrast

CT

and

fluoroscopic

images

of

Patient

a

Right

ureter

straight

arrow

displaced

anteriorly

from

the

psoas

muscle

at

the

level

of

Compare

this

to

the

normally

positioned

left

ureter

curved

arrow

in

close

proximity

to

the

psoas

muscle

b

Right

ureter

straight

arrow

in

the

inguinal

hernia

c

Anterograde

nephrostogram

with

the

patient

in

prone

position

at

the

time

of

nephrostomy

tube

insertion

The

right

ureter

loops

below

the

level

of

the

pubic

symphysis

into

a

large

right

inguinal

hernia

one

arrow

with

evidence

of

obstruction

at

the

level

of

the

ureterovesical

junction

two

arrows


Figure 2: 15-year-old thalassemic diabetic female patient. (a) Axial T2WI revealed decreased signal intensity of the liver. (b) Axial T2 * GRE images revealed more drop in the signal intensity of the liver.

Figure

old

thalassemic

diabetic

female

patient

a

Axial

revealed

decreased

signal

intensity

of

the

liver

b

Axial

GRE

images

revealed

more

drop

in

the

signal

intensity

of

the

liver


Figure 6. Transmission electron micrographs of Trypanosoma noyesi sp. n. A. longitudinal section showing the kinetoplast (white arrowhead), flagellum, acidocalcisomes (black arrowhead), glycosomes (white asterix), and reservosomes (black asterix). B. transverse section revealing the flagellum, axoneme, mitochondrion (arrowhead), and extension of the flagellar sheath (asterix). C. kinetoplast exhibiting kDNA enclosed in a membrane (arrowhead), which is attached to the basal body (asterix).

Figure

Transmission

electron

micrographs

of

Trypanosoma

noyesi

sp

n.

A.

longitudinal

section

showing

the

kinetoplast

white

arrowhead

flagellum

acidocalcisomes

black

arrowhead

glycosomes

white

asterix

and

reservosomes

black

asterix

B.

transverse

section

revealing

the

flagellum

axoneme

mitochondrion

arrowhead

and

extension

of

the

flagellar

sheath

asterix

C.

kinetoplast

exhibiting

kDNA

enclosed

in

a

membrane

arrowhead

which

is

attached

to

the

basal

body

asterix


Fig. 1 Chest radiograph of a 65-year-old man (RM) with histiocytic medullary reticulosis receiving cytotoxic drugs and prednisone: (a) shows a bilateral, predominantly nodular infiltrate; (b) demonstrates the position of the biopsy forceps in the left upper lung zone during fibreoptic bronchoscopy. Aspergillus fumigatus was isolated on both transbronchial brush and forceps biopsies. Aspergillus precipitins rose from a titre of 1:8 to 1:32.

Fig

Chest

radiograph

of

a

old

man

RM

with

histiocytic

medullary

reticulosis

receiving

cytotoxic

drugs

and

prednisone

a

shows

a

bilateral

predominantly

nodular

infiltrate

b

demonstrates

the

position

of

the

biopsy

forceps

in

the

left

upper

lung

zone

during

fibreoptic

bronchoscopy

Aspergillus

fumigatus

was

isolated

on

both

transbronchial

brush

and

forceps

biopsies

Aspergillus

precipitins

rose

from

a

titre

of

to


Fig. 1. Focal lesion seen on transrectal ultrasound (TRUS) and prostate magnetic resonance imaging in a 55-year-old man. (A) TRUS shows low echoic nodular lesion in left peripheral zone (arrow). TRUS guided biopsy for this lesion confirmed that the lesion was prostate cancer. (B) T2 weighted axial magnetic resonance scan shows relatively well defined nodular lesion in left peripheral zone (arrow). (C) Apparent diffusion coefficient map shows signal drop at the same lesion, which suggest diffusion restriction (arrow).

Fig

Focal

lesion

seen

on

transrectal

ultrasound

TRUS

and

prostate

magnetic

resonance

imaging

in

a

old

man

A

TRUS

shows

low

echoic

nodular

lesion

in

left

peripheral

zone

arrow

TRUS

guided

biopsy

for

this

lesion

confirmed

that

the

lesion

was

prostate

cancer

B

weighted

axial

magnetic

resonance

scan

shows

relatively

well

defined

nodular

lesion

in

left

peripheral

zone

arrow

C

Apparent

diffusion

coefficient

map

shows

signal

drop

at

the

same

lesion

which

suggest

diffusion

restriction

arrow


Fig 9. A 61 year old female with a 3.2 cm hypoechoic nodule seen in the right lobe on transverse image (a) that has markedly increased blood flow on color Doppler (b), a very stiff nodular component on strain elastography (c). On 2D-SWE (d) the nodule within the lesion had a stiffness value of 7.0m/s while the majority of the lesion has a stiffness of 2.28m/s. On biopsy the nodule was diagnosed to be a papillary carcinoma

Fig

A

year

old

female

with

a

cm

hypoechoic

nodule

seen

in

the

right

lobe

on

transverse

image

a

that

has

markedly

increased

blood

flow

on

color

Doppler

b

a

very

stiff

nodular

component

on

strain

elastography

c

On

SWE

d

the

nodule

within

the

lesion

had

a

stiffness

value

of

m/s

while

the

majority

of

the

lesion

has

a

stiffness

of

m/s

On

biopsy

the

nodule

was

diagnosed

to

be

a

papillary

carcinoma


Fig. 1. Chest X-rays: on the initial medical examination (a) and after chest tube drainage (b). Computed tomography scans: before the operation (c, d), after the operation (e), and after 3 cycles of pembrolizumab (f). It was observed that the right hilar and bilateral mediastinal lymphadenopathy and pleural dissemination have decreased.

Fig

Chest

X

rays

on

the

initial

medical

examination

a

and

after

chest

tube

drainage

b

Computed

tomography

scans

before

the

operation

c

d

after

the

operation

e

and

after

cycles

of

pembrolizumab

f

It

was

observed

that

the

right

hilar

and

bilateral

mediastinal

lymphadenopathy

and

pleural

dissemination

have

decreased


Figure 3: (a) T1 axial magnetic resonance imaging (MRI) with contrast revealing an enhancing mass in the left atrium. (b) T1 sagittal MRI with contrast showing an enhancing mass in fourth ventricle b a

Figure

a

axial

magnetic

resonance

imaging

MRI

with

contrast

revealing

an

enhancing

mass

in

the

left

atrium

b

sagittal

MRI

with

contrast

showing

an

enhancing

mass

in

fourth

ventricle

b

a


Fig. 9 a, b CECT in axial and coronal sections show infected right inguinal hernia mesh repair with collections (arrows) and sinus tracks (arrowhead). Culture yielded Mycobacterium chelonae. c Coronal plain CT in another patient shows soft tissue thickening and collection along the mesh tackers (arrow). d Laparoscopic retrieval of infected mesh (arrow) which was covered with pus and granulation tissue

Fig

a

b

CECT

in

axial

and

coronal

sections

show

infected

right

inguinal

hernia

mesh

repair

with

collections

arrows

and

sinus

tracks

arrowhead

Culture

yielded

Mycobacterium

chelonae

c

Coronal

plain

CT

in

another

patient

shows

soft

tissue

thickening

and

collection

along

the

mesh

tackers

arrow

d

Laparoscopic

retrieval

of

infected

mesh

arrow

which

was

covered

with

pus

and

granulation

tissue


Fig. 3. Reconstructed slices of a grating-based, multimodal CT scan of a biological sample (a formalin fixated infant mouse). Shown are sagittal (top row) and axial (bottom row) slices. The reconstruction yields quantitative values of linear attenuation coe cient µ (a), refractive index decrement (b, c) and linear di↵usion coe cient ✏ (d). For the phase image (c), an iterative reconstruction scheme [20] was used instead of conventional FBP reconstruction in order to reduce stripe artifacts and noise. The scalebar corresponds to 2 mm.

Fig

Reconstructed

slices

of

a

grating

based

multimodal

CT

scan

of

a

biological

sample

a

formalin

fixated

infant

mouse

Shown

are

sagittal

top

row

and

axial

bottom

row

slices

The

reconstruction

yields

quantitative

values

of

linear

attenuation

coe

cient

µ

a

refractive

index

decrement

b

c

and

linear

di

usion

coe

cient

d

For

the

phase

image

c

an

iterative

reconstruction

scheme

was

used

instead

of

conventional

FBP

reconstruction

in

order

to

reduce

stripe

artifacts

and

noise

The

scalebar

corresponds

to

mm


Figure 4: CT angiogram demonstrating the evolution of an acute thrombus to an intravascular chronic “web” in the proximal right descending PA at the level of the right middle lobe take-off. The time interval between the left (A) and right (B) images is 1 year.

Figure

CT

angiogram

demonstrating

the

evolution

of

an

acute

thrombus

to

an

intravascular

chronic

web

in

the

proximal

right

descending

PA

at

the

level

of

the

right

middle

lobe

take

off

The

time

interval

between

the

left

A

and

right

B

images

is

year


Figure 1. Pedigree and brain MRI. (A) Pedigree of the family. Black symbol ¼ affected with spastic ataxia and optic atrophy; grey symbol ¼ affected with tremor; square ¼ male; circle ¼ female; diamond ¼ masked gender (for anonymization purposes); diagonal line ¼ deceased. (B and C) Brain MRI of patient III-5 at age 63: (B) Coronal T2 image showing optical atrophy (arrows), and (C) midsagittal T1 image showing mild atrophy of the superior vermis (arrow).

Figure

Pedigree

and

brain

MRI

A

Pedigree

of

the

family

Black

symbol

¼

affected

with

spastic

ataxia

and

optic

atrophy

grey

symbol

¼

affected

with

tremor

square

¼

male

circle

¼

female

diamond

¼

masked

gender

for

anonymization

purposes

diagonal

line

¼

deceased

B

and

C

Brain

MRI

of

patient

at

age

B

Coronal

image

showing

optical

atrophy

arrows

and

C

midsagittal

image

showing

mild

atrophy

of

the

superior

vermis

arrow


Fig. 4 – Dual-mode strain elastography. Dual-mode strain elastography imaging simultaneously displays the acoustic properties in a standard B-mode image (A) and the elastic properties in an elastogram (B); a color overlay on top of the B-mode image that represents tissue elasticity. As shown in the elastography color bar (left), current practice depicts red regions as tissue that is more elastic (less stiff) than blue regions. This demonstrates that the lesion is harder than the adjacent normal testicular parenchyma.

Fig

Dual

mode

strain

elastography

Dual

mode

strain

elastography

imaging

simultaneously

displays

the

acoustic

properties

in

a

standard

B

mode

image

A

and

the

elastic

properties

in

an

elastogram

B

a

color

overlay

on

top

of

the

B

mode

image

that

represents

tissue

elasticity

As

shown

in

the

elastography

color

bar

left

current

practice

depicts

red

regions

as

tissue

that

is

more

elastic

less

stiff

than

blue

regions

This

demonstrates

that

the

lesion

is

harder

than

the

adjacent

normal

testicular

parenchyma


Fig. 1 Chest CT scans (sagittal (a), horizontal (b) and axial (c)) show the absence of the trachea and bronchi (B) arising from the oesophagus (OE) via a fistula (arrow ↖)

Fig

Chest

CT

scans

sagittal

a

horizontal

b

and

axial

c

show

the

absence

of

the

trachea

and

bronchi

B

arising

from

the

oesophagus

OE

via

a

fistula

arrow


Fig. 3. Molar pregnancy in a 24-year-old woman. (A) Perpendicular to the endometrial line T2-weighted MR image of the pelvis showing a snowstorm appearance. (B) Axial T1-weighted MR image showing focal hypersignal for a round and crescent intratumoral hemorrhage, (C) DWI with a b value of 800 showing the same hemorrhage as a bright focus, and (D) an ADC map showing the same hemorrhage as a signal void focus.

Fig

Molar

pregnancy

in

a

old

woman

A

Perpendicular

to

the

endometrial

line

MR

image

of

the

pelvis

showing

a

snowstorm

appearance

B

Axial

MR

image

showing

focal

hypersignal

for

a

round

and

crescent

intratumoral

hemorrhage

C

DWI

with

a

b

value

of

showing

the

same

hemorrhage

as

a

bright

focus

and

D

an

ADC

map

showing

the

same

hemorrhage

as

a

signal

void

focus


Figure 9: Sacral plasmocytoma. MR: (a) Sagittal T1-WI shows homogenous mass involving S1, S2 and S3 with intermediate signal intensity. (b) Sagittal T2-WI show a high signal intensity of the mass extending into the pelvis, epidural space, and posterior elements.

Figure

Sacral

plasmocytoma

MR

a

Sagittal

shows

homogenous

mass

involving

and

with

intermediate

signal

intensity

b

Sagittal

show

a

high

signal

intensity

of

the

mass

extending

into

the

pelvis

epidural

space

and

posterior

elements


Fig. 1. CT-scan showing the intralobar sequestration in the left lower lobe with an anomalous aortic branch in case 1 (a) and case (b). CT, computed tomography.

Fig

CT

scan

showing

the

intralobar

sequestration

in

the

left

lower

lobe

with

an

anomalous

aortic

branch

in

case

a

and

case

b

CT

computed

tomography


Fig. 4 A 64-year-old male with moderately differentiated adenocarcinoma of the appendix (case 4). The coronal (a) and axial (b) contrastenhanced CT scan images reveal a dilated, fluid-filled appendix with mural thickening and enhancement (white arrows). There is also evidence of periappendiceal inflammatory fat stranding (white asterisk) which is best appreciated in the axial image

Fig

A

old

male

with

moderately

differentiated

adenocarcinoma

of

the

appendix

case

The

coronal

a

and

axial

b

contrastenhanced

CT

scan

images

reveal

a

dilated

fluid

filled

appendix

with

mural

thickening

and

enhancement

white

arrows

There

is

also

evidence

of

periappendiceal

inflammatory

fat

stranding

white

asterisk

which

is

best

appreciated

in

the

axial

image


Fig. 2. 55 years old male, initial simple X-rays shows nonspecific findings except mild degenerative changes. (A) MRI shows mild compression of cecal sac at Lt. lateral space and minimal fluid signal intensity adjacent Lt. L3 with preserved adjacent intervertebral disc spaces. (B) Successful healing process is observed after HD # 6 months.

Fig

years

old

male

initial

simple

X

rays

shows

nonspecific

findings

except

mild

degenerative

changes

A

MRI

shows

mild

compression

of

cecal

sac

at

Lt

lateral

space

and

minimal

fluid

signal

intensity

adjacent

Lt

with

preserved

adjacent

intervertebral

disc

spaces

B

Successful

healing

process

is

observed

after

HD

months


Fig. 4. Cytoskeletal inhibitors reverse raft aggregation at signalincompetent NK immune synapses. For each effector͞target cell pair, Nomarski imaging is shown to the left of fluorescence (original magnification ϫ160). NK cell lipid rafts are visible as Alexa 568-conjugated CTX ␤ staining (red), and target cells express HLA-Cw4-GFP (green). (A) YTS͞KIR2DL1(Y377S,Y407S) and 721.221͞HLA-Cw4-GFP, no drug treatment. (B) YTS͞KIR2DL1(Y377S,Y407S) cells pretreated with 10 M cytochalasin D before co-incubation with 721.221͞HLA-Cw4-GFP targets. Note that ligand clustering remains unperturbed, whereas rafts, which were polarized in the untreated sample, are dispersed. (C) YTS͞KIR2DL1(Y377S,Y407S) cells pretreated with 10 M colchicine before coincubation with 721.221͞HLA-Cw4-GFP targets again display ligand clustering but no raft polarization.

Fig

Cytoskeletal

inhibitors

reverse

raft

aggregation

at

signalincompetent

NK

immune

synapses

For

each

effector͞target

cell

pair

Nomarski

imaging

is

shown

to

the

left

of

fluorescence

original

magnification

NK

cell

lipid

rafts

are

visible

as

Alexa

CTX

staining

red

and

target

cells

express

HLA

green

A

and

no

drug

treatment

B

cells

pretreated

with

M

cytochalasin

D

before

co

incubation

with

targets

Note

that

ligand

clustering

remains

unperturbed

whereas

rafts

which

were

polarized

in

the

untreated

sample

are

dispersed

C

cells

pretreated

with

M

colchicine

before

coincubation

with

targets

again

display

ligand

clustering

but

no

raft

polarization


Figure 1 In vivo endoscopic ultrasound guided needle based confocal laser endomicroscopy, ex vivo confocal laser endomicroscopy, and histopathology of intraductal papillary mucinous neoplasms. Panels A, B and C are from subject 1 (gastric subtype with high grade dysplasia). Panels D, E, and F are from subject 2 (intestinal subtype with high grade dysplasia). Complete “fingerlike” papillae are observed in both in vivo and ex vivo CLE. The vascular core in ex vivo CLE imaging is better defined. Histopathology (panels C, F): 40 × magnification; HE stain.

Figure

In

vivo

endoscopic

ultrasound

guided

needle

based

confocal

laser

endomicroscopy

ex

vivo

confocal

laser

endomicroscopy

and

histopathology

of

intraductal

papillary

mucinous

neoplasms

Panels

A

B

and

C

are

from

subject

gastric

subtype

with

high

grade

dysplasia

Panels

D

E

and

F

are

from

subject

intestinal

subtype

with

high

grade

dysplasia

Complete

fingerlike

papillae

are

observed

in

both

in

vivo

and

ex

vivo

CLE

The

vascular

core

in

ex

vivo

CLE

imaging

is

better

defined

Histopathology

panels

C

F

magnification

HE

stain


Figure 1. A neonatal excitotoxic lesion of the ventral hippocampus shown in a diagram adapted from the atlas of Paxinos and Watson (Paxinos and Watson 1986) (A) and in photomicrographs of Nissl-stained coronal brain sections through the hippocampus of an adult rat with a neonatal sham (B) and ibotenic acid lesion (C). A gray area in a diagram indicates the boundaries of a lesion. Arrows point to the area showing loss of neurons in the ventral hippocampus in the lesioned brain (C).

Figure

A

neonatal

excitotoxic

lesion

of

the

ventral

hippocampus

shown

in

a

diagram

adapted

from

the

atlas

of

Paxinos

and

Watson

Paxinos

and

Watson

A

and

in

photomicrographs

of

Nissl

stained

coronal

brain

sections

through

the

hippocampus

of

an

adult

rat

with

a

neonatal

sham

B

and

ibotenic

acid

lesion

C

A

gray

area

in

a

diagram

indicates

the

boundaries

of

a

lesion

Arrows

point

to

the

area

showing

loss

of

neurons

in

the

ventral

hippocampus

in

the

lesioned

brain

C


Fig 3. The different steps for quantification of total adipose tissue by micro-computed tomography. Anesthetized mice are placed in a supine position in an imaging cell; three-dimensional x-ray images are acquired on the CT part of a μSPECT-μCT (eXplore speCZT Vision 120, GE, Waukesha, USA). Volumes are reconstructed with a voxel size equal to 100x100x100 μm 3 ; reconstructed images are filtered with a Gaussian filter to reduce noise. (a) Whole body scan. (b) Selection of whole body volume. (c) Choice of threshold level based on fat pad (FP). (d) Representation of total adipose tissue with subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). (e) Isosurface representation of whole body in grey and fat in yellow. https://doi.org/10.1371/journal.pone.0183523.g003

Fig

The

different

steps

for

quantification

of

total

adipose

tissue

by

micro

computed

tomography

Anesthetized

mice

are

placed

in

a

supine

position

in

an

imaging

cell

three

dimensional

x

ray

images

are

acquired

on

the

CT

part

of

a

μSPECT

μCT

eXplore

speCZT

Vision

GE

Waukesha

USA

Volumes

are

reconstructed

with

a

voxel

size

equal

to

μm

reconstructed

images

are

filtered

with

a

Gaussian

filter

to

reduce

noise

a

Whole

body

scan

b

Selection

of

whole

body

volume

c

Choice

of

threshold

level

based

on

fat

pad

FP

d

Representation

of

total

adipose

tissue

with

subcutaneous

adipose

tissue

SAT

and

visceral

adipose

tissue

VAT

e

Isosurface

representation

of

whole

body

in

grey

and

fat

in

yellow


Figure 9: Fecal impaction: (a and b) Erect and supine plain abdominal radiograph in a 75‑year‑old man presenting with abdominal distension and worsening lower abdominal pain demonstrates dilatation of the large bowel loops. Computed tomography scan (c and d) performed subsequently demonstrates large amount of stool in the sigmoid colon and rectum (arrows) which resulted in large bowel dilatation. No mass was identified and the patient was managed conservatively with enemas. Repeat computed tomography performed subsequently demonstrates resolution of the impacted feces with residual fluid in the sigmoid colon (e).

Figure

Fecal

impaction

a

and

b

Erect

and

supine

plain

abdominal

radiograph

in

a

man

presenting

with

abdominal

distension

and

worsening

lower

abdominal

pain

demonstrates

dilatation

of

the

large

bowel

loops

Computed

tomography

scan

c

and

d

performed

subsequently

demonstrates

large

amount

of

stool

in

the

sigmoid

colon

and

rectum

arrows

which

resulted

in

large

bowel

dilatation

No

mass

was

identified

and

the

patient

was

managed

conservatively

with

enemas

Repeat

computed

tomography

performed

subsequently

demonstrates

resolution

of

the

impacted

feces

with

residual

fluid

in

the

sigmoid

colon

e


Figure 2: (a) A plain computed tomography (CT) scan (axial view) indicated vertebral artery injury. (b) An enhanced CT scan (coronal view) demonstrated left vertebral artery interruption

Figure

a

A

plain

computed

tomography

CT

scan

axial

view

indicated

vertebral

artery

injury

b

An

enhanced

CT

scan

coronal

view

demonstrated

left

vertebral

artery

interruption


Fig. 1. Axial (a) and coronal (b) CT scans in the portal venous phase showing evidence of peri-splenic haematoma (*) and haemoperitoneum (**).

Fig

Axial

a

and

coronal

b

CT

scans

in

the

portal

venous

phase

showing

evidence

of

peri

splenic

haematoma

and

haemoperitoneum


Figure 1 (A) Chest X-ray PA view shows a well-defined homogenous round opacity in right mid and lower zone. (B and C) (Supplementary material online, Videos S1 and S2) Echocardiogram shows large well-defined anechoic cystic mass compressing the right atrium with sand drift echoes 'falling snowflakes sign' and septa. (D) Computed tomography thorax showed water-attenuation cyst with lamellar wall in midlobe of right lung causing distal lobar collapse. (E) Surgical removal through right anterior thoracotomy incision revealing a 500 Â 300 mm cyst, which was excised by marsupialization. (F) Histopathology section using haematoxylin and eosin stain showed endocyst with hooklets.

Figure

A

Chest

X

ray

PA

view

shows

a

well

defined

homogenous

round

opacity

in

right

mid

and

lower

zone

B

and

C

Supplementary

material

online

Videos

and

Echocardiogram

shows

large

well

defined

anechoic

cystic

mass

compressing

the

right

atrium

with

sand

drift

echoes

falling

snowflakes

sign

and

septa

D

Computed

tomography

thorax

showed

water

attenuation

cyst

with

lamellar

wall

in

midlobe

of

right

lung

causing

distal

lobar

collapse

E

Surgical

removal

through

right

anterior

thoracotomy

incision

revealing

a

Â

mm

cyst

which

was

excised

by

marsupialization

F

Histopathology

section

using

haematoxylin

and

eosin

stain

showed

endocyst

with

hooklets


Figure 2. A 30-year-old female patient with giant cell tumor (GCT) of the left distal femur. (A) X-ray film reveals osteolytic destruction and cortical thinning at the left femoral condyle. (B) and (C) T1-weighted MRI reveals low signal at the distal femur and a lateral visible tumor penetrating the front side of the cortex. (D) 4 days after surgery, postoperative X-ray reveals bone cement filling and internal fixation are normal. (E) and (F) 22 months after surgery, X-ray shows that the joint space is normal, no lucent zones surround the bone cement, internal fixations are firm and the joint function is normal.

Figure

A

old

female

patient

with

giant

cell

tumor

GCT

of

the

left

distal

femur

A

X

ray

film

reveals

osteolytic

destruction

and

cortical

thinning

at

the

left

femoral

condyle

B

and

C

MRI

reveals

low

signal

at

the

distal

femur

and

a

lateral

visible

tumor

penetrating

the

front

side

of

the

cortex

D

days

after

surgery

postoperative

X

ray

reveals

bone

cement

filling

and

internal

fixation

are

normal

E

and

F

months

after

surgery

X

ray

shows

that

the

joint

space

is

normal

no

lucent

zones

surround

the

bone

cement

internal

fixations

are

firm

and

the

joint

function

is

normal


Fig. 1 Case 1 illustrates the phenotype of varicella-associated AIS. Brain imaging from a 17 month old boy who presented with an acute L hemiparesis, having had chickenpox 8 months earlier. (a) coronal FLAIR images showing high signal in the basal ganglia (caudate and lentiform nuclei) on the right. (b) 2D time of flight magnetic resonance imaging showing reduced flow in the distal left M1 segment of the middle cerebral

Fig

Case

illustrates

the

phenotype

of

varicella

associated

AIS

Brain

imaging

from

a

month

old

boy

who

presented

with

an

acute

L

hemiparesis

having

had

chickenpox

months

earlier

a

coronal

FLAIR

images

showing

high

signal

in

the

basal

ganglia

caudate

and

lentiform

nuclei

on

the

right

b

time

of

flight

magnetic

resonance

imaging

showing

reduced

flow

in

the

distal

left

segment

of

the

middle

cerebral


Figure 2: MR imaging revealing a non-enhancing cystic-appearing lesion growing off the conus medullaris at L1- L2 in the spinal with hyperintensity on a sagittal T1-weighted image (a) and hypointensity on a T2-weighted image (b)

Figure

MR

imaging

revealing

a

non

enhancing

cystic

appearing

lesion

growing

off

the

conus

medullaris

at

in

the

spinal

with

hyperintensity

on

a

sagittal

image

a

and

hypointensity

on

a

image

b


Fig. 1 Fundus examination. a Peripheral schisis with a large hole can be noticed in the retinography of the right eye. b OCT B-scan across the fovea. Intraretinal cysts can be observed along the inner nuclear layer. c Three-dimensional reconstruction across the hole in the peripheral schisis of the inferior retina. The inner retinal layers are missed in the right side of the image, while in the left side are still present but detached from the outer retina

Fig

Fundus

examination

a

Peripheral

schisis

with

a

large

hole

can

be

noticed

in

the

retinography

of

the

right

eye

b

OCT

B

scan

across

the

fovea

Intraretinal

cysts

can

be

observed

along

the

inner

nuclear

layer

c

Three

dimensional

reconstruction

across

the

hole

in

the

peripheral

schisis

of

the

inferior

retina

The

inner

retinal

layers

are

missed

in

the

right

side

of

the

image

while

in

the

left

side

are

still

present

but

detached

from

the

outer

retina


Figure 2 New ASPSCR1-TFE3 renal cell carcinomas with t(X;17)(p11;q25). (a–e) H& E-stained sections of nested pseudopapillary growth pattern featuring dyscohesive cells with voluminous cytoplasm. (f) Strong, nuclear labeling for TFE3 protein.

Figure

New

renal

cell

carcinomas

with

a

e

H

E

stained

sections

of

nested

pseudopapillary

growth

pattern

featuring

dyscohesive

cells

with

voluminous

cytoplasm

f

Strong

nuclear

labeling

for

protein


Figure 3. Abdominal CT, in the third year of D-penicillamine and zinc sulfate therapy, shows minimal heterogeneity of liver parenchyma (A), dilatation of portal vein and splenomegaly (B), but no nodular lesions.

Figure

Abdominal

CT

in

the

third

year

of

D

penicillamine

and

zinc

sulfate

therapy

shows

minimal

heterogeneity

of

liver

parenchyma

A

dilatation

of

portal

vein

and

splenomegaly

B

but

no

nodular

lesions


Fig. 2. Photomicrographs of lamprey hindbrain and spinal cord. A: transverse section through the cerebellum and isthmus at the level of the trigeminal sensory and motor roots. B: transverse section through the medulla at the level of the trigeminal motor nucleus and descending trigeminal tract (outlined by dashed line). C: transverse section at an isthmal level showing the degenerating trigeminal sensory root. D: transverse section of the spinal cord showing the degenerating descending trigeminal tract in the dorsal funiculus. Bar scales equal 100 ~m. Magnifications of A and B are identical, as are magnifications of C and D. Abbreviations: ag, alar gray; dV, descending trigeminal tract; V, trigeminal motor nucleus; Vs, trigeminal sensory root; Vm, trigeminal motor root.

Fig

Photomicrographs

of

lamprey

hindbrain

and

spinal

cord

A

transverse

section

through

the

cerebellum

and

isthmus

at

the

level

of

the

trigeminal

sensory

and

motor

roots

B

transverse

section

through

the

medulla

at

the

level

of

the

trigeminal

motor

nucleus

and

descending

trigeminal

tract

outlined

by

dashed

line

C

transverse

section

at

an

isthmal

level

showing

the

degenerating

trigeminal

sensory

root

D

transverse

section

of

the

spinal

cord

showing

the

degenerating

descending

trigeminal

tract

in

the

dorsal

funiculus

Bar

scales

equal

~m

Magnifications

of

A

and

B

are

identical

as

are

magnifications

of

C

and

D.

Abbreviations

ag

alar

gray

dV

descending

trigeminal

tract

V

trigeminal

motor

nucleus

Vs

trigeminal

sensory

root

Vm

trigeminal

motor

root


Fig. 7 Plexiform neurofibroma. a Axial T1-weighted MR image demonstrates a mass that is iso−/hypointense to muscle (arrows). b Axial T2-weighted MR image demonstrates numerous hyperintense masses involving the left carotid space (white arrows). The left internal carotid artery (i) is displaced posterolaterally. Note the characteristic “fish-eye” or “target” appearance of this lesion (black arrows). This patient had neurofibromatosis, and extensive transspatial neurofibromas can be seen in other portions of the neck (arrowheads)

Fig

Plexiform

neurofibroma

a

Axial

MR

image

demonstrates

a

mass

that

is

iso−/hypointense

to

muscle

arrows

b

Axial

MR

image

demonstrates

numerous

hyperintense

masses

involving

the

left

carotid

space

white

arrows

The

left

internal

carotid

artery

i

is

displaced

posterolaterally

Note

the

characteristic

fish

eye

or

target

appearance

of

this

lesion

black

arrows

This

patient

had

neurofibromatosis

and

extensive

transspatial

neurofibromas

can

be

seen

in

other

portions

of

the

neck

arrowheads


Figure 2: Colour scale brain perfusion SPECT analysis with 99mTx-HMPAO fused with CT scan for patient 1: (a) December 2017; (b) July 2018.

Figure

Colour

scale

brain

perfusion

SPECT

analysis

with

HMPAO

fused

with

CT

scan

for

patient

a

December

b

July


Fig. 2. Cross-sectional area (CSA) of multifidus muscles in a patient with right L5 radiculopathy. (A) shows axial planes at the mid-spinous process level of L4 vertebra (L4 MSP), the mid-spinous process level of L5 vertebra (L5 MSP), and the mid-sacral crest level of S1 vertebra (S1 MSC). (B) indicates total muscle CSA of multifidus muscles (TMCSA) at the S1 MSC. (C) indicates pure muscle CSA of multifidus muscles (PMCSA) at the S1 MSC.

Fig

Cross

sectional

area

CSA

of

multifidus

muscles

in

a

patient

with

right

radiculopathy

A

shows

axial

planes

at

the

mid

spinous

process

level

of

vertebra

MSP

the

mid

spinous

process

level

of

vertebra

MSP

and

the

mid

sacral

crest

level

of

vertebra

MSC

B

indicates

total

muscle

CSA

of

multifidus

muscles

TMCSA

at

the

MSC

C

indicates

pure

muscle

CSA

of

multifidus

muscles

PMCSA

at

the

MSC


Figure 2. The Spectrum of Fundus Findings among Different Families with Mutations in FAM161A (A–I) Imaging of three pairs of siblings from families with the p.Thr452SerfsX3 mutation, showing different severity of funduscopic changes: bone-spicule-like pigmentation was observed to only a limited degree in most patients (A, C, D, F as compared to H, I), but many patients showed grayish spots extending from the arcades to the periphery. These correlated with spots of hypofluorescence on AF imaging (B, E, G). In addition, a ring of hyperfluoresence around the fovea could be observed in many cases (B, E, G). (J and K). Color fundus mosaic (J) and AF imaging of the macular area (K) in a patient with the R523X mutation. (L and M) OCT imaging shows marked thinning of the outer nuclear layer, with relative preservation under the fovea itself. Fine wrinkling of the retina can be seen in one of the scans (M), related to an epiretinal membrane.

Figure

The

Spectrum

of

Fundus

Findings

among

Different

Families

with

Mutations

in

A

I

Imaging

of

three

pairs

of

siblings

from

families

with

the

p

mutation

showing

different

severity

of

funduscopic

changes

bone

spicule

like

pigmentation

was

observed

to

only

a

limited

degree

in

most

patients

A

C

D

F

as

compared

to

H

I

but

many

patients

showed

grayish

spots

extending

from

the

arcades

to

the

periphery

These

correlated

with

spots

of

hypofluorescence

on

AF

imaging

B

E

G

In

addition

a

ring

of

hyperfluoresence

around

the

fovea

could

be

observed

in

many

cases

B

E

G

J

and

K

Color

fundus

mosaic

J

and

AF

imaging

of

the

macular

area

K

in

a

patient

with

the

mutation

L

and

M

OCT

imaging

shows

marked

thinning

of

the

outer

nuclear

layer

with

relative

preservation

under

the

fovea

itself

Fine

wrinkling

of

the

retina

can

be

seen

in

one

of

the

scans

M

related

to

an

epiretinal

membrane


Figure 1. (A) Echocardiography (four-chamber view) depicting the mass (arrows) in the right atrium (RA). (B) Magnetic resonance imaging illustrating the rounded mass (arrows) attached to the right atrial free wall. LA, left atrium; LV, left ventricle; RA, right atrium; RV, right ventricle.

Figure

A

Echocardiography

four

chamber

view

depicting

the

mass

arrows

in

the

right

atrium

RA

B

Magnetic

resonance

imaging

illustrating

the

rounded

mass

arrows

attached

to

the

right

atrial

free

wall

LA

left

atrium

LV

left

ventricle

RA

right

atrium

RV

right

ventricle


Fig. 1. Areas of decreased blood flow measured using H 2 15 0 PET in an unmedicated patient during the experience of auditory and visual hallucinations (P b 0.01). Axial (A) and midsagittal (B) views showing decreased blood flow in right rostral prefrontal and ventromedial prefrontal cortices as well as in left dorsolateral prefrontal subcortical region. See [59] for methodological details and for areas of increased blood flow during hallucinations.

Fig

Areas

of

decreased

blood

flow

measured

using

H

PET

in

an

unmedicated

patient

during

the

experience

of

auditory

and

visual

hallucinations

P

b

Axial

A

and

midsagittal

B

views

showing

decreased

blood

flow

in

right

rostral

prefrontal

and

ventromedial

prefrontal

cortices

as

well

as

in

left

dorsolateral

prefrontal

subcortical

region

See

for

methodological

details

and

for

areas

of

increased

blood

flow

during

hallucinations


Figure 2. A, The mass showed in T1-weighted coronary MRI. B, The mass showed in T1-weighted transverse MRI. C, The mass showed in T2-weighted coronary MRI. D, The mass showed in T2-weighted transverse MRI. CT = computed tomography, MRI = magnetic resonance imaging.

Figure

A

The

mass

showed

in

coronary

MRI

B

The

mass

showed

in

transverse

MRI

C

The

mass

showed

in

coronary

MRI

D

The

mass

showed

in

transverse

MRI

CT

computed

tomography

MRI

magnetic

resonance

imaging


Fig. 4 a Sagittal atlas map and b photomicrographs of adjacent sections stained for myelin, d AChE and c immunoreacted for SMI-32, e CR, and f CB. Case Hb3. Scale bar (upper left panel): 2 mm

Fig

a

Sagittal

atlas

map

and

b

photomicrographs

of

adjacent

sections

stained

for

myelin

d

AChE

and

c

immunoreacted

for

e

CR

and

f

CB

Case

Scale

bar

upper

left

panel

mm


Fig. 1. A–D: This figure shows ultrasonography still frames of ovarian xenotransplants (arrowheads) and different antral follicle states (arrows). Due to the ultrasonographical findings (one antral follicle, 1.4 mm in diameter, A), we decided to attempt the first oocyte recovery trial six weeks after transplantation. The animal was administered 30 IU eCG s.c. to support oocyte maturation. It was anesthetized 36 h later and its abdominal cavity was opened again. The kidney was exteriorized and the antral follicle cavity was punctured using a 100 µl syringe. However, no oocyte was recovered from the aspirated fluid. Nine days later we found a new 1.3 mm sized antral follicle (B) in the same animal that grew 2.2 (C) and 3.3 (D) mm in size. The white bars always indicate 10 mm.

Fig

A

D

This

figure

shows

ultrasonography

still

frames

of

ovarian

xenotransplants

arrowheads

and

different

antral

follicle

states

arrows

Due

to

the

ultrasonographical

findings

one

antral

follicle

mm

in

diameter

A

we

decided

to

attempt

the

first

oocyte

recovery

trial

six

weeks

after

transplantation

The

animal

was

administered

IU

eCG

s.c

to

support

oocyte

maturation

It

was

anesthetized

h

later

and

its

abdominal

cavity

was

opened

again

The

kidney

was

exteriorized

and

the

antral

follicle

cavity

was

punctured

using

a

µl

syringe

However

no

oocyte

was

recovered

from

the

aspirated

fluid

Nine

days

later

we

found

a

new

mm

sized

antral

follicle

B

in

the

same

animal

that

grew

C

and

D

mm

in

size

The

white

bars

always

indicate

mm


Fig. 8. Images obtained in 76-year-old male with glioblastoma. A. T2-weighted MR image shows intra-axial mass with surrounding edema in right parietal lobe. B. DWI shows high signal intensity in corresponding lesion, and thus suggesting high tumor cellularity. C. Contrast-enhanced, axial, T1-weighted MR image shows necrotic, contrastenhancing mass in same lesion. D. Contrast-enhanced SWI shows additional information regarding microhemorrhage and tumor microvessels around tumor necrosis seen on contrast-enhanced, T1-weighted image. DWI = diffusion-weighted MR imaging, SWI = susceptibility-weighted imaging

Fig

Images

obtained

in

old

male

with

glioblastoma

A.

MR

image

shows

intra

axial

mass

with

surrounding

edema

in

right

parietal

lobe

B.

DWI

shows

high

signal

intensity

in

corresponding

lesion

and

thus

suggesting

high

tumor

cellularity

C.

Contrast

enhanced

axial

MR

image

shows

necrotic

contrastenhancing

mass

in

same

lesion

D.

Contrast

enhanced

SWI

shows

additional

information

regarding

microhemorrhage

and

tumor

microvessels

around

tumor

necrosis

seen

on

contrast

enhanced

image

DWI

diffusion

weighted

MR

imaging

SWI

susceptibility

weighted

imaging


Figure 1: Sample neuronal cell rendered by maximum intensity projection of different portions of the original 3D fluorescence microscopy image stack. This example emphasizes the multiscale nature of the neuron segmentation problem as part of the digital reconstruction task: from the whole-neuron level (A), through the level of dendritic branches and bifurcations (B), to the level of individual spines (C). It also serves to illustrate the complexity of the problem: while this is a fairly high-quality data set, still several branches are poorly stained and show low contrast, causing visual ambiguities (A). In practical live-cell imaging experiments the noise level may be considerably higher. A poor contrast-to-noise ratio is especially problematic for segmentation of the spines (C), which are usually already poorly imaged due to limited resolution, and may easily appear as detached blobs.

Figure

Sample

neuronal

cell

rendered

by

maximum

intensity

projection

of

different

portions

of

the

original

fluorescence

microscopy

image

stack

This

example

emphasizes

the

multiscale

nature

of

the

neuron

segmentation

problem

as

part

of

the

digital

reconstruction

task

from

the

whole

neuron

level

A

through

the

level

of

dendritic

branches

and

bifurcations

B

to

the

level

of

individual

spines

C

It

also

serves

to

illustrate

the

complexity

of

the

problem

while

this

is

a

fairly

high

quality

data

set

still

several

branches

are

poorly

stained

and

show

low

contrast

causing

visual

ambiguities

A

In

practical

live

cell

imaging

experiments

the

noise

level

may

be

considerably

higher

A

poor

contrast

to

noise

ratio

is

especially

problematic

for

segmentation

of

the

spines

C

which

are

usually

already

poorly

imaged

due

to

limited

resolution

and

may

easily

appear

as

detached

blobs


Figure 6. MRI nodal abnormalities in three patients with prostate cancer. The left panel shows conventional MRI and the middle panel showed MRI obtained 24 hs after the administration of lymphotropic superparamagnetic nanoparticles. The right panel shows corresponding histologic analysis (hematoxylin and eosin). A, a homogeneous decrease in signal intensity due to the accumulation of lymphotropic superparamagnetic nanoparticles in a normal lymph node in the left iliac region. B, conventional MRI shows high signal intensity in an unenlarged iliac lymph node completely replaced by tumor. The nodal signal intensity remains high with nanoparticles. C, conventional MRI shows high signal intensity in a retroperitoneal node with micrometastases. MRI with lymphotropic superparamagnetic nanoparticles demonstrates two hyperintense within the node, corresponding to 2-mm metastases. (Reprinted and modified with the permission from reference [88])

Figure

MRI

nodal

abnormalities

in

three

patients

with

prostate

cancer

The

left

panel

shows

conventional

MRI

and

the

middle

panel

showed

MRI

obtained

hs

after

the

administration

of

lymphotropic

superparamagnetic

nanoparticles

The

right

panel

shows

corresponding

histologic

analysis

hematoxylin

and

eosin

A

a

homogeneous

decrease

in

signal

intensity

due

to

the

accumulation

of

lymphotropic

superparamagnetic

nanoparticles

in

a

normal

lymph

node

in

the

left

iliac

region

B

conventional

MRI

shows

high

signal

intensity

in

an

unenlarged

iliac

lymph

node

completely

replaced

by

tumor

The

nodal

signal

intensity

remains

high

with

nanoparticles

C

conventional

MRI

shows

high

signal

intensity

in

a

retroperitoneal

node

with

micrometastases

MRI

with

lymphotropic

superparamagnetic

nanoparticles

demonstrates

two

hyperintense

within

the

node

corresponding

to

metastases

Reprinted

and

modified

with

the

permission

from

reference


Figure 1. Mammographic and ultrasound findings of a 35-year-old woman with ductal carcinomas in situ (DCIS). Screening mammography (A) demonstrated a focal asymmetry in the left upper breast (arrow) and computer-aided detection applied mammography (B) detected the lesion (asterisk, marked by computer-aided detection program) (arrow). The breast ultrasound (C) demonstrated a ductal change in the left upper breast (arrows); this was a pathologically proven DCIS.

Figure

Mammographic

and

ultrasound

findings

of

a

old

woman

with

ductal

carcinomas

in

situ

DCIS

Screening

mammography

A

demonstrated

a

focal

asymmetry

in

the

left

upper

breast

arrow

and

computer

aided

detection

applied

mammography

B

detected

the

lesion

asterisk

marked

by

computer

aided

detection

program

arrow

The

breast

ultrasound

C

demonstrated

a

ductal

change

in

the

left

upper

breast

arrows

this

was

a

pathologically

proven

DCIS


Fig 2. — Dose distribution for intensity-modulated protons (A) or intensity-modulated photons (B) in a transverse plane (computed tomography slice) through the center of the tumor in a patient with a thoracic paraspinal sarcoma. The isodose contours are represented by different colors (corresponding values in CGE are displayed below the figure). Note the significant reduction in lung and cardiac dose with intensitymodulated protons. From Weber DC, Trofimov AV, DeLaney TF, et al. A treatment planning comparison of intensity modulated photon and proton therapy for paraspinal sarcomas. Int J Radiat Oncol Biol Phys. 2004;58:1596-1606. Reprinted with permission from Elsevier.

Fig

Dose

distribution

for

intensity

modulated

protons

A

or

intensity

modulated

photons

B

in

a

transverse

plane

computed

tomography

slice

through

the

center

of

the

tumor

in

a

patient

with

a

thoracic

paraspinal

sarcoma

The

isodose

contours

are

represented

by

different

colors

corresponding

values

in

CGE

are

displayed

below

the

figure

Note

the

significant

reduction

in

lung

and

cardiac

dose

with

intensitymodulated

protons

From

Weber

DC

Trofimov

AV

DeLaney

TF

et

al

A

treatment

planning

comparison

of

intensity

modulated

photon

and

proton

therapy

for

paraspinal

sarcomas

Int

J

Radiat

Oncol

Biol

Phys

Reprinted

with

permission

from

Elsevier


Figure 5. The 5-HT 2A receptor is expressed in regions appropriate for mediating propagation of activity A, fluo-4-loaded dextran-injected motor neurones during [Ca 2+ ] i imaging experiment. B, horizontal 20 µm cryostat section demonstrating immunoreactivity for the 5-HT 2A receptor. Strong staining is observed in the midline commissural area (vertical line indicates midline), and in the marginal zone lateral to the midline. This animal was dextran-injected in the b1 branchial arch, and motor neurones can be seen in the V motor group (nV) in red. Strong receptor immunoreactivity is also observed in the sensory axons of the V th sensory ganglion (gV). Arrows at right of figure show the dorsal and ventral axes, and apply to part C as well. C, co-immunolabelling for serotonin reactivity (red) and 5-HT 2A receptor (green). Receptor immunoreactivity is strong in processes crossing the midline, in a few serotonin-immunolabelled neurones immediately lateral to the midline (arrowheads), and in the marginal zone extending laterally. Vertical bar indicates midline.

Figure

The

receptor

is

expressed

in

regions

appropriate

for

mediating

propagation

of

activity

A

dextran

injected

motor

neurones

during

Ca

i

imaging

experiment

B

horizontal

µm

cryostat

section

demonstrating

immunoreactivity

for

the

receptor

Strong

staining

is

observed

in

the

midline

commissural

area

vertical

line

indicates

midline

and

in

the

marginal

zone

lateral

to

the

midline

This

animal

was

dextran

injected

in

the

branchial

arch

and

motor

neurones

can

be

seen

in

the

V

motor

group

nV

in

red

Strong

receptor

immunoreactivity

is

also

observed

in

the

sensory

axons

of

the

V

th

sensory

ganglion

gV

Arrows

at

right

of

figure

show

the

dorsal

and

ventral

axes

and

apply

to

part

C

as

well

C

co

immunolabelling

for

serotonin

reactivity

red

and

receptor

green

Receptor

immunoreactivity

is

strong

in

processes

crossing

the

midline

in

a

few

serotonin

immunolabelled

neurones

immediately

lateral

to

the

midline

arrowheads

and

in

the

marginal

zone

extending

laterally

Vertical

bar

indicates

midline


Figure 1. CT scan of the patient’s liver showed lipiodol accumulation ((A) post-TACE day 14), and liver abscess formation (arrow) of S7 ((B) post-TACE day 87). CT = computed tomography, TACE = transarterial chemoembolization.

Figure

CT

scan

of

the

patient

’s

liver

showed

lipiodol

accumulation

A

post

TACE

day

and

liver

abscess

formation

arrow

of

B

post

TACE

day

CT

computed

tomography

TACE

transarterial

chemoembolization


Fig. 5 Planning of angiographic planes. Using reformation reconstruction of multidetector row computed tomography (MDCT), the appropriate aortic valve plane for transcatheter aortic valve implantation can be anticipated (a). The ideal angiographic projection should be one that aligns all the three aortic cusps in a straight line, perpendicular to the aortic valve plane (b). LCC left coronary cusp, NCC non-coronary cusp, RCC right coronary cusp

Fig

Planning

of

angiographic

planes

Using

reformation

reconstruction

of

multidetector

row

computed

tomography

MDCT

the

appropriate

aortic

valve

plane

for

transcatheter

aortic

valve

implantation

can

be

anticipated

a

The

ideal

angiographic

projection

should

be

one

that

aligns

all

the

three

aortic

cusps

in

a

straight

line

perpendicular

to

the

aortic

valve

plane

b

LCC

left

coronary

cusp

NCC

non

coronary

cusp

RCC

right

coronary

cusp


Figure 2. Axial cerebral magnetic resonance imaging scan 18 months after liver transplantation showing the regression of the basal ganglia abnormalities on 2 different slices (inferior [top] and superior [bottom]).

Figure

Axial

cerebral

magnetic

resonance

imaging

scan

months

after

liver

transplantation

showing

the

regression

of

the

basal

ganglia

abnormalities

on

different

slices

inferior

top

and

superior

bottom


Fig. 1 Elbow haemophilic arthropathy: (a) anteroposterior radiograph; (b) lateral view.

Fig

Elbow

haemophilic

arthropathy

a

anteroposterior

radiograph

b

lateral

view


Fig. 1. Transthoracic echocardiography apical 4-chamber view revealing a complex membrane (arrow) with its septum (arrowhead) subdividing the LA into two chambers (A). Cardiovascular magnetic resonance 4-chamber steady-state free precession image showing the membrane (arrow) with its septum (arrowhead) (B). Transesophageal echocardiogram mid-esophageal 4-chamber (C) and modified 2-chamber (D) views demonstrating the membrane which is attached to the coumadin ridge just below the left pulmonary veins (D). LA: true left atrium, LV: left ventricle, PVC: pulmonary venous chamber, RA: right atrium, RV: right ventricle.

Fig

Transthoracic

echocardiography

apical

view

revealing

a

complex

membrane

arrow

with

its

septum

arrowhead

subdividing

the

LA

into

two

chambers

A

Cardiovascular

magnetic

resonance

steady

state

free

precession

image

showing

the

membrane

arrow

with

its

septum

arrowhead

B

Transesophageal

echocardiogram

mid

esophageal

C

and

modified

D

views

demonstrating

the

membrane

which

is

attached

to

the

coumadin

ridge

just

below

the

left

pulmonary

veins

D

LA

true

left

atrium

LV

left

ventricle

PVC

pulmonary

venous

chamber

RA

right

atrium

RV

right

ventricle


Figure 1: Axial cross-sections were obtained by computed tomography in patients with normal and high ABI. The image in a 47-year-old patient with normal ABI showed no obvious calcification (arrow) in abdominal aorta A. However, abdominal aorta calcification was evident (arrow) in a 46-year-old patient with high ABI B. Scale bar=1cm.

Figure

Axial

cross

sections

were

obtained

by

computed

tomography

in

patients

with

normal

and

high

ABI

The

image

in

a

old

patient

with

normal

ABI

showed

no

obvious

calcification

arrow

in

abdominal

aorta

A.

However

abdominal

aorta

calcification

was

evident

arrow

in

a

old

patient

with

high

ABI

B.

Scale

cm


Fig. 5 The axial (A) and sagittal (B) micro-CT MIP images show the location of the micrograph (C). Whilst the endplate portion of radial annular-endplate tears usually occurred at the cartilaginous/ vertebral endplate junction, in two discs the right mediolateral portion of the endplate tear occurred at the annulus/endplate junction (disc 5-L12 is shown). In both discs, only fibres inclined in the direction of the applied axial rotation were ruptured, in this case those of the in-plane lamellae (I), but not the cross-sectioned lamellae (C). IV inferior vertebra, rg residual gel. The arrow marked ‘ep’ indicates the thickness of the cartilaginous endplate

Fig

The

axial

A

and

sagittal

B

micro

CT

MIP

images

show

the

location

of

the

micrograph

C

Whilst

the

endplate

portion

of

radial

annular

endplate

tears

usually

occurred

at

the

cartilaginous/

vertebral

endplate

junction

in

two

discs

the

right

mediolateral

portion

of

the

endplate

tear

occurred

at

the

annulus

endplate

junction

disc

is

shown

In

both

discs

only

fibres

inclined

in

the

direction

of

the

applied

axial

rotation

were

ruptured

in

this

case

those

of

the

in

plane

lamellae

I

but

not

the

cross

sectioned

lamellae

C

IV

inferior

vertebra

rg

residual

gel

The

arrow

marked

ep

indicates

the

thickness

of

the

cartilaginous

endplate


Figure 1. X-ray diffraction (XRD) patterns of nanograined (NG) and coarse-grained (CG) Ti-6Al-4V alloys (a). Optical micrograph (b) and SEM magnified images (c) for CG microstructure, TEM bright-field (d), and dark-field (e) micrograph for NG microstructure.

Figure

X

ray

diffraction

XRD

patterns

of

nanograined

NG

and

coarse

grained

CG

alloys

a

Optical

micrograph

b

and

SEM

magnified

images

c

for

CG

microstructure

TEM

bright

field

d

and

dark

field

e

micrograph

for

NG

microstructure


Fig. 4 A 58-year-old woman with hepatitis C infection who had been detected as having a right hepatic nodule on contrast-enhanced CT (a, arrow). PET was requested for further assessment, and revealed FDG avidity of the hepatic mass (b, arrow) as well as FDG avid deposits below the anterior abdominal wall (c, arrow head). Contrast-

Fig

A

old

woman

with

hepatitis

C

infection

who

had

been

detected

as

having

a

right

hepatic

nodule

on

contrast

enhanced

CT

a

arrow

PET

was

requested

for

further

assessment

and

revealed

FDG

avidity

of

the

hepatic

mass

b

arrow

as

well

as

FDG

avid

deposits

below

the

anterior

abdominal

wall

c

arrow

head

Contrast-


FIGURE 4. Cerenkov luminescence imaging of a notched COB type plaque sutured close to the optic nerve. (A) Plaque is misaligned relative to the optic nerve. (B) Plaque is centered around the optic nerve but not close to the nerve. (C) Plaque is adjacent to the optic nerve. (D) Plaque is tilted away from the sclera, leading to an irregular and diffuse demarcation of the Cerenkov emission. Color scales indicate camera counts per second.

FIGURE

Cerenkov

luminescence

imaging

of

a

notched

COB

type

plaque

sutured

close

to

the

optic

nerve

A

Plaque

is

misaligned

relative

to

the

optic

nerve

B

Plaque

is

centered

around

the

optic

nerve

but

not

close

to

the

nerve

C

Plaque

is

adjacent

to

the

optic

nerve

D

Plaque

is

tilted

away

from

the

sclera

leading

to

an

irregular

and

diffuse

demarcation

of

the

Cerenkov

emission

Color

scales

indicate

camera

counts

per

second


Figure 6 Case of schwannoma. Endoscopy reveals a slightly elevated lesion in the posterior wall of the body. Endoscopic ultrasonography (EUS) detects a round, hypoechoic tumor originating from the fourth layer and elastography as a hard tumor. Histology shows spindle cells with S-100 positivity by EUS-guided fine-needle aspiration (FNA). HE, hematoxylin and eosin.

Figure

Case

of

schwannoma

Endoscopy

reveals

a

slightly

elevated

lesion

in

the

posterior

wall

of

the

body

Endoscopic

ultrasonography

EUS

detects

a

round

hypoechoic

tumor

originating

from

the

fourth

layer

and

elastography

as

a

hard

tumor

Histology

shows

spindle

cells

with

positivity

by

EUS

guided

fine

needle

aspiration

FNA

HE

hematoxylin

and

eosin


Figure 1 Endoscopic findings of multiple inflammatory polyps. A and B: Caps of fibrinopurulent exudate from the sigmoid colon to the rectum interspersed with normal colonic mucosa; C and D: Magnifying endoscopy shows an area in the cap of amorphous fibrinopurulent exudate and tortuous and long branching crypts under the cap; E: Endoscopic ultrasonography showed significant thickening of the colonic mucosa layers.

Figure

Endoscopic

findings

of

multiple

inflammatory

polyps

A

and

B

Caps

of

fibrinopurulent

exudate

from

the

sigmoid

colon

to

the

rectum

interspersed

with

normal

colonic

mucosa

C

and

D

Magnifying

endoscopy

shows

an

area

in

the

cap

of

amorphous

fibrinopurulent

exudate

and

tortuous

and

long

branching

crypts

under

the

cap

E

Endoscopic

ultrasonography

showed

significant

thickening

of

the

colonic

mucosa

layers


Fig. 4. 71-year-old woman who fell from chair after spontaneous intracranial hemorrhage. A. Coronal STIR images show increased signal intensity along posterior subcutaneous area of both scapular regions (arrows). B. Autopsy photography of upper back reveals fresh soft tissue hemorrhage in corresponding areas (arrows).

Fig

old

woman

who

fell

from

chair

after

spontaneous

intracranial

hemorrhage

A.

Coronal

STIR

images

show

increased

signal

intensity

along

posterior

subcutaneous

area

of

both

scapular

regions

arrows

B.

Autopsy

photography

of

upper

back

reveals

fresh

soft

tissue

hemorrhage

in

corresponding

areas

arrows


Fig. 3 Dye injection study following percutaneous abscess drainage and pigtail catheter insertion (a AP radiograph, b CT scan reconstruction, both following dye injection). The abscess cavity is seen communicating only with the L4–L5 disc level

Fig

Dye

injection

study

following

percutaneous

abscess

drainage

and

pigtail

catheter

insertion

a

AP

radiograph

b

CT

scan

reconstruction

both

following

dye

injection

The

abscess

cavity

is

seen

communicating

only

with

the

disc

level


Figure 1. Endoscopic ultrasound-guided celiac plexus neurolysis (EUS-CPN). (a) Schematic of EUSCPN; (b) Color flow EUS image from the lesser curvature of the stomach showing a longitudinal view of the aorta (Ao) and celiac artery (CA); (c) EUS image of EUS-CPN during needle puncture. A 22- gauge needle was advanced adjacent to the CA origin. Arrowheads indicate the needle tip. Blue: vascular flow.

Figure

Endoscopic

ultrasound

guided

celiac

plexus

neurolysis

EUS

CPN

a

Schematic

of

EUSCPN

b

Color

flow

EUS

image

from

the

lesser

curvature

of

the

stomach

showing

a

longitudinal

view

of

the

aorta

Ao

and

celiac

artery

CA

c

EUS

image

of

EUS

CPN

during

needle

puncture

A

gauge

needle

was

advanced

adjacent

to

the

CA

origin

Arrowheads

indicate

the

needle

tip

Blue

vascular

flow


Figure 1 Pretreatment of the right eye of a patient with pathological myopia. Top left, fundus photograph shows characteristic of pathological myopia and signs of choroidal neovascularisation (CNV). Top right, optical coherence tomography (OCT) shows subretinal fluid (asterisk). The CNV complex also is identifiable in OCT scan (white arrow). Bottom left, early phase of angiogram shows a classic CNV membrane. Bottom right, leakage on a late phase angiogram.

Figure

Pretreatment

of

the

right

eye

of

a

patient

with

pathological

myopia

Top

left

fundus

photograph

shows

characteristic

of

pathological

myopia

and

signs

of

choroidal

neovascularisation

CNV

Top

right

optical

coherence

tomography

OCT

shows

subretinal

fluid

asterisk

The

CNV

complex

also

is

identifiable

in

OCT

scan

white

arrow

Bottom

left

early

phase

of

angiogram

shows

a

classic

CNV

membrane

Bottom

right

leakage

on

a

late

phase

angiogram


Figure 5 (A) lupus nephritis class V. light micrograph of a glomerulus with diffuse membranous glomerulonephritis (h&e stained, 200×). (B) P53 nuclear immunostaining of apoptotic cells in class II of clN, score II/III (200×). (C) Ki-67 nuclear immunostaining of mesangial proliferative glomeruli in class II of clN, score II/III (200×). (D) Moderate to severe mononuclear tubulointerstitial nephritis (h&e stained, 200×). Abbreviation: clN, childhood lupus nephritis.

Figure

A

lupus

nephritis

class

V.

light

micrograph

of

a

glomerulus

with

diffuse

membranous

glomerulonephritis

h&e

stained

B

nuclear

immunostaining

of

apoptotic

cells

in

class

II

of

clN

score

II

III

C

nuclear

immunostaining

of

mesangial

proliferative

glomeruli

in

class

II

of

clN

score

II

III

D

Moderate

to

severe

mononuclear

tubulointerstitial

nephritis

h&e

stained

Abbreviation

clN

childhood

lupus

nephritis


Figure 1 A 36-year-old patient with aggressive non-Hodgkin s lymphoma who initially presented with a huge left axillary mass and partial response at completion of first-line chemotherapy. At re-staging 10 months later (a c), PET/CT with FDG demonstrates, in addition to local residual disease over the left axillary region, at least four occult hepatic lesions (fused-CT images not shown). Only one of the lesions (arrow) can be retrospectively identified on the contrast-enhanced abdominal CT performed 9 days earlier (d). The patient s condition deteriorated rapidly after the PET/CT exam.

Figure

A

old

patient

with

aggressive

non

Hodgkin

s

lymphoma

who

initially

presented

with

a

huge

left

axillary

mass

and

partial

response

at

completion

of

first

line

chemotherapy

At

re

staging

months

later

a

c

PET

CT

with

FDG

demonstrates

in

addition

to

local

residual

disease

over

the

left

axillary

region

at

least

four

occult

hepatic

lesions

fused

CT

images

not

shown

Only

one

of

the

lesions

arrow

can

be

retrospectively

identified

on

the

contrast

enhanced

abdominal

CT

performed

days

earlier

d

The

patient

s

condition

deteriorated

rapidly

after

the

PET

CT

exam


Figure 1: A. Venogram, performed with contrast injection in the left basilic vein, demonstrating a suboccluded left subclavian vein (red arrow) and the presence of a collateral vein (white arrows) draining into the right subclavian vein. B. Chest radiograph (anteroposterior view) obtained the day after the procedure. The coronary sinus pacing lead (green arrows) passes from the left subclavian vein to its final position via a collateral vein and the right subclavian vein. The CS lead is placed in a posterior location.

Figure

A.

Venogram

performed

with

contrast

injection

in

the

left

basilic

vein

demonstrating

a

suboccluded

left

subclavian

vein

red

arrow

and

the

presence

of

a

collateral

vein

white

arrows

draining

into

the

right

subclavian

vein

B.

Chest

radiograph

anteroposterior

view

obtained

the

day

after

the

procedure

The

coronary

sinus

pacing

lead

green

arrows

passes

from

the

left

subclavian

vein

to

its

final

position

via

a

collateral

vein

and

the

right

subclavian

vein

The

CS

lead

is

placed

in

a

posterior

location


Figure 1 HRCT images of the lower chest in a 16 year-old boy (Case 2) at presentation (A), and 8 weeks later after a 6-week course of erythromycin 250mg twice daily. The bilateral bronchiectasis and prominent centri-lobular nodules with a tree-in-bud pattern shows marked improvement on the follow-up scan.

Figure

HRCT

images

of

the

lower

chest

in

a

year

old

boy

Case

at

presentation

A

and

weeks

later

after

a

course

of

erythromycin

mg

twice

daily

The

bilateral

bronchiectasis

and

prominent

centri

lobular

nodules

with

a

tree

in

bud

pattern

shows

marked

improvement

on

the

follow

up

scan


Fig. 1. A representative axial slice from the input images used for detecting WMHs at run time (left) and ground-truth data used for training the WMH detection method and validating the results (right)

Fig

A

representative

axial

slice

from

the

input

images

used

for

detecting

WMHs

at

run

time

left

and

ground

truth

data

used

for

training

the

WMH

detection

method

and

validating

the

results

right


FIGURE 3. Using methods from Rucker et al., 90 (a) preoperative liver model and registered swabbed point cloud acquired from intraoperative liver surface are shown with ultrasound image of segment III portal pedicle in (b), and (c) showing manual segmentation of structure. In (d) we see the planned model cloud with ultrasound slice (white arrow) showing alignment of pedicle based on rigid registration, and (e) is the close-up. Notice how inferior vessel region does not align with corresponding vascular structure. In (f), a deformation correction driven by the closest point mismatch in data shown in (a) has been performed, and (g) shows the new location of the structure as well as modified shapes to vasculature. It should be noted that in this example ultrasound data was used for validation only, i.e., no localized ultrasound structures were used within the alignment algorithm, only data shown in (a) was used. We should further note that the alignment error of this feature after rigid registration was estimated at 5.5 6 2.6 mm (10.9 mm maximum error). The error was reduced to 2.4 6 1.5 mm (5.4 mm maximum error) after modelbased deformation correction.

FIGURE

Using

methods

from

Rucker

et

al

a

preoperative

liver

model

and

registered

swabbed

point

cloud

acquired

from

intraoperative

liver

surface

are

shown

with

ultrasound

image

of

segment

III

portal

pedicle

in

b

and

c

showing

manual

segmentation

of

structure

In

d

we

see

the

planned

model

cloud

with

ultrasound

slice

white

arrow

showing

alignment

of

pedicle

based

on

rigid

registration

and

e

is

the

close

up

Notice

how

inferior

vessel

region

does

not

align

with

corresponding

vascular

structure

In

f

a

deformation

correction

driven

by

the

closest

point

mismatch

in

data

shown

in

a

has

been

performed

and

g

shows

the

new

location

of

the

structure

as

well

as

modified

shapes

to

vasculature

It

should

be

noted

that

in

this

example

ultrasound

data

was

used

for

validation

only

i.e.

no

localized

ultrasound

structures

were

used

within

the

alignment

algorithm

only

data

shown

in

a

was

used

We

should

further

note

that

the

alignment

error

of

this

feature

after

rigid

registration

was

estimated

at

mm

mm

maximum

error

The

error

was

reduced

to

mm

mm

maximum

error

after

modelbased

deformation

correction


Figure 3. Immunohistochemical localization of aFGF immunoreactivity in cerebral cortex and hippocampus. A shows a low-power photomicrograph of a coronal section spanning all of cerebral cortex and most of hippocampus. Few aFGF-positive neurons are observed in these areas. The cell identified by an arrow in A is shown at larger magnification in B. The irregular multipolar morphology of this cell is representative for the morphology of most aFGF-positive cortical and hippocampal neurons. Fibers containing aFGF immunoreactivity in cingulate cortex are shown in C. The density of labeled fibers appears to be too high for fibers that would originate solely from the few aFGF-positive neurons within cortex. Scale bars: A, 120 pm; B, 15 pm; C, 8 pm.

Figure

Immunohistochemical

localization

of

aFGF

immunoreactivity

in

cerebral

cortex

and

hippocampus

A

shows

a

low

power

photomicrograph

of

a

coronal

section

spanning

all

of

cerebral

cortex

and

most

of

hippocampus

Few

aFGF

positive

neurons

are

observed

in

these

areas

The

cell

identified

by

an

arrow

in

A

is

shown

at

larger

magnification

in

B.

The

irregular

multipolar

morphology

of

this

cell

is

representative

for

the

morphology

of

most

aFGF

positive

cortical

and

hippocampal

neurons

Fibers

containing

aFGF

immunoreactivity

in

cingulate

cortex

are

shown

in

C.

The

density

of

labeled

fibers

appears

to

be

too

high

for

fibers

that

would

originate

solely

from

the

few

aFGF

positive

neurons

within

cortex

Scale

bars

A

pm

B

pm

C

pm


Figure 1. A. Axial contrast-enhanced CT scan of the lower leg of a patient with plasma cell leukemia and anterior tibial compartment pyomyositis (patient 4) demonstrates edema and swelling in the anterior compartment with an associated rim-enhancing intramuscular abscess (arrow). B. Coronal T2-weighted MR image confirms the presence of a fluid signal intensity abscess (arrows) within the tibialis anterior and extensor hallucis longus muscles.

Figure

A.

Axial

contrast

enhanced

CT

scan

of

the

lower

leg

of

a

patient

with

plasma

cell

leukemia

and

anterior

tibial

compartment

pyomyositis

patient

demonstrates

edema

and

swelling

in

the

anterior

compartment

with

an

associated

rim

enhancing

intramuscular

abscess

arrow

B.

Coronal

MR

image

confirms

the

presence

of

a

fluid

signal

intensity

abscess

arrows

within

the

tibialis

anterior

and

extensor

hallucis

longus

muscles


Figure 1. A, Macular grid 5 (MG5) scan pattern (768 A-scans spiral from center outward; grid spacing, 0.14 mm in central 3 mm and 0.29 mm between 3 and 5 mm). B, Optical coherence tomography (OCT) image of MG5. C, Fast Macular Thickness Map scan pattern (6 radial line scans). D, Six OCT images corresponding to each of the 6 lines.

Figure

A

Macular

grid

scan

pattern

A

scans

spiral

from

center

outward

grid

spacing

mm

in

central

mm

and

mm

between

and

mm

B

Optical

coherence

tomography

OCT

image

of

C

Fast

Macular

Thickness

Map

scan

pattern

radial

line

scans

D

Six

OCT

images

corresponding

to

each

of

the

lines


Figure 3. Morphometric analysis of the ribosome population in the G1 and G2 phases. (A) Example of a higher magnification view of a G1 cell with a mounted triple-lattice grid for counting the density of ribosomes. (B) An expanded view shows how the grid was mounted on a region proximal to the nuclear envelope. (C) An enlarged view shows the exact co-localization of the ribosome particle on the center white dot of the grid that represents one positive score. NM, nuclear membrane; No, nucleolus. doi:10.1371/journal.pone.0032820.g003

Figure

Morphometric

analysis

of

the

ribosome

population

in

the

and

phases

A

Example

of

a

higher

magnification

view

of

a

cell

with

a

mounted

triple

lattice

grid

for

counting

the

density

of

ribosomes

B

An

expanded

view

shows

how

the

grid

was

mounted

on

a

region

proximal

to

the

nuclear

envelope

C

An

enlarged

view

shows

the

exact

co

localization

of

the

ribosome

particle

on

the

center

white

dot

of

the

grid

that

represents

one

positive

score

NM

nuclear

membrane

No

nucleolus


Figure 1 Different ALK staining expression at IHC with clone 5A4 (A) and Ventana D5F3 CD assay (B). Insert in image (A) shows the ALK positivity in signet ring tumor cells with a thin rim of brownish-stained cytoplasm dislocated under the nuclear membrane. FISH analysis showing tumor cells with normal ALK set-up with one normal fusion signal and one single red/orange signal (C); ALK positivity by gene deletion with single 3' orange rearranged signals (deleted green signal) (D, arrowheads) and ALK positivity by inversion with “broken apart” signals, 2 or more signal diameters apart (E, arrows). IHC, immunohistochemistry; ALK, anaplastic lymphoma kinase; FISH, fluorescence in situ hybridization.

Figure

Different

ALK

staining

expression

at

IHC

with

clone

A

and

Ventana

CD

assay

B

Insert

in

image

A

shows

the

ALK

positivity

in

signet

ring

tumor

cells

with

a

thin

rim

of

brownish

stained

cytoplasm

dislocated

under

the

nuclear

membrane

FISH

analysis

showing

tumor

cells

with

normal

ALK

set

up

with

one

normal

fusion

signal

and

one

single

red

orange

signal

C

ALK

positivity

by

gene

deletion

with

single

orange

rearranged

signals

deleted

green

signal

D

arrowheads

and

ALK

positivity

by

inversion

with

broken

apart

signals

or

more

signal

diameters

apart

E

arrows

IHC

immunohistochemistry

ALK

anaplastic

lymphoma

kinase

FISH

fluorescence

in

situ

hybridization


Fig. 3. X-ray crystal structure of the PPAR␥͞RXR␣ LBDs. (A) The PPAR␥ protein is displayed as a yellow worm and the RXR␣ protein as a dark blue worm with the LxxLL peptides in purple. The agonist ligands GW409544 and 9-cis-retinoic acid are displayed in space-filling representations colored by atom type. (B) A 2F o Ϫ Fc omit map showing the electron density (1) of the ligand and the surrounding residues. The amino acids Phe-282, Tyr-323, and Tyr-473 are indicated. (C) Key hydrogen bonding (yellow line) and hydrophobic (white broken line) interactions between GW409544 and the PPAR␥ protein and two bound water molecules.

Fig

X

ray

crystal

structure

of

the

PPAR

͞RXR

LBDs

A

The

PPAR

protein

is

displayed

as

a

yellow

worm

and

the

RXR

protein

as

a

dark

blue

worm

with

the

LxxLL

peptides

in

purple

The

agonist

ligands

and

retinoic

acid

are

displayed

in

space

filling

representations

colored

by

atom

type

B

A

o

Ϫ

Fc

omit

map

showing

the

electron

density

of

the

ligand

and

the

surrounding

residues

The

amino

acids

and

are

indicated

C

Key

hydrogen

bonding

yellow

line

and

hydrophobic

white

broken

line

interactions

between

and

the

PPAR

protein

and

two

bound

water

molecules


Fig. 2. Subcellular localization of InsP3R isoforms in HepG2 cells. Type II and III InsP 3Rs were localized by confocal immunofluorescence. Cells were doublelabeled with isoform-specific InsP 3R antibodies (green) or with added propidium iodide (red) to identify the nucleus. (A) Type II InsP 3R labeling. (B) Propidium iodide. (C) Merged images demonstrate that type II InsP 3R is in both cytosol and nucleus. Notice the reticular pattern of nuclear staining. (D) Type III InsP 3R labeling. (E) Propidium iodide. (F) Merged images demonstrate that type III InsP 3R is in the cytosol but not in the nucleus of HepG2 cells. Labeling with secondary but not primary antibody plus propidium iodide reveals no nonspecific staining (not shown).

Fig

Subcellular

localization

of

isoforms

in

cells

Type

II

and

III

InsP

were

localized

by

confocal

immunofluorescence

Cells

were

doublelabeled

with

isoform

specific

InsP

antibodies

green

or

with

added

propidium

iodide

red

to

identify

the

nucleus

A

Type

II

InsP

labeling

B

Propidium

iodide

C

Merged

images

demonstrate

that

type

II

InsP

is

in

both

cytosol

and

nucleus

Notice

the

reticular

pattern

of

nuclear

staining

D

Type

III

InsP

labeling

E

Propidium

iodide

F

Merged

images

demonstrate

that

type

III

InsP

is

in

the

cytosol

but

not

in

the

nucleus

of

cells

Labeling

with

secondary

but

not

primary

antibody

plus

propidium

iodide

reveals

no

nonspecific

staining

not

shown


Fig. 2. 61-year-old woman with well differentiated retroperitoneal liposarcoma. A. Axial contrast-enhanced CT image at time of diagnosis demonstrates large predominantly fat containing mass in left retroperitoneum (arrows). Presence of heterogeneous non-lipomatous component differentiates it from simple lipoma. B, C. Axial T1-out-of-phase and post-gadolinium fatsuppressed T1-weighted images demonstrate mass to have areas of signal drop on out-of-phase imaging with no significant enhancement (arrows). Patient underwent surgery and histopathology showed well-differentiated liposarcoma.

Fig

old

woman

with

well

differentiated

retroperitoneal

liposarcoma

A.

Axial

contrast

enhanced

CT

image

at

time

of

diagnosis

demonstrates

large

predominantly

fat

containing

mass

in

left

retroperitoneum

arrows

Presence

of

heterogeneous

non

lipomatous

component

differentiates

it

from

simple

lipoma

B

C.

Axial

of

phase

and

post

gadolinium

fatsuppressed

images

demonstrate

mass

to

have

areas

of

signal

drop

on

out

of

phase

imaging

with

no

significant

enhancement

arrows

Patient

underwent

surgery

and

histopathology

showed

well

differentiated

liposarcoma


Fig. 12. Morphological features of the manchette during rat spermatogenesis. (A,B) Electron microscopy. (A) This electron micrograph shows the absence of the manchette at the start of acrosome formation in rat spermatogenesis. N: nucleus, PA: proacrosome (B) This electron micrograph shows the presence of the manchette (arrows) during nuclear shaping in rat spermatogenesis. N: nucleus (C,D) Immunofluorescent staining. These immunofluorescent light micrographs show the localization of tubulin (green staining) and KIFC1 (red staining) in rat spermatids. The manchette appears to surround the nucleus in a skirt-shaped manner. doi:10.1371/journal.pone.0076065.g012

Fig

Morphological

features

of

the

manchette

during

rat

spermatogenesis

A

B

Electron

microscopy

A

This

electron

micrograph

shows

the

absence

of

the

manchette

at

the

start

of

acrosome

formation

in

rat

spermatogenesis

N

nucleus

PA

proacrosome

B

This

electron

micrograph

shows

the

presence

of

the

manchette

arrows

during

nuclear

shaping

in

rat

spermatogenesis

N

nucleus

C

D

Immunofluorescent

staining

These

immunofluorescent

light

micrographs

show

the

localization

of

tubulin

green

staining

and

red

staining

in

rat

spermatids

The

manchette

appears

to

surround

the

nucleus

in

a

skirt

shaped

manner


Fig. 4 55-year-old male patient with biopsy proven HCC. Hepatitis C and cirrhosis etiology. Child-Pugh class A, BCLC B, ECOG 0. The arrows indicate the lesions targeted with delivery of Lipiodol. Note that the lesion depiction on the pre- and intra-procedural imaging matches with the post-TACE imaging, and especially with the hypoenhancement 1 month post-TA

Fig

old

male

patient

with

biopsy

proven

HCC

Hepatitis

C

and

cirrhosis

etiology

Child

Pugh

class

A

BCLC

B

ECOG

The

arrows

indicate

the

lesions

targeted

with

delivery

of

Lipiodol

Note

that

the

lesion

depiction

on

the

pre-

and

intra

procedural

imaging

matches

with

the

post

TACE

imaging

and

especially

with

the

hypoenhancement

month

post

TA


Figure 6 | a) X-ray Phase Contrast Tomography image of the lumbarsacral region of the spinal cord, where the central region containing the empty canal is marked. b) Longitudinal slice of the sample in the region selected in a). The regions 1, 2, 3 highlight the central canal, grey matter and white matter, respectively. c) Zoom of the image at the interface

Figure

a

X

ray

Phase

Contrast

Tomography

image

of

the

lumbarsacral

region

of

the

spinal

cord

where

the

central

region

containing

the

empty

canal

is

marked

b

Longitudinal

slice

of

the

sample

in

the

region

selected

in

a

The

regions

highlight

the

central

canal

grey

matter

and

white

matter

respectively

c

Zoom

of

the

image

at

the

interface


Fig. 1. Case 1. (A) Recurrent choroidal hemangioma with submacular fluid, previously treated by photocoagulation, before intravitreal bevacizumab. Ultrasonography reveals a tumor thickness of 1.6 mm. Optical coherence tomography (OCT) demonstrates the presence of submacular fluid. (B) Two months after intravitreal bevacizumab. The hemangioma thickness is reduced on ultrasonography and the subretinal fluid around the tumor is absorbed on OCT.

Fig

Case

A

Recurrent

choroidal

hemangioma

with

submacular

fluid

previously

treated

by

photocoagulation

before

intravitreal

bevacizumab

Ultrasonography

reveals

a

tumor

thickness

of

mm

Optical

coherence

tomography

OCT

demonstrates

the

presence

of

submacular

fluid

B

Two

months

after

intravitreal

bevacizumab

The

hemangioma

thickness

is

reduced

on

ultrasonography

and

the

subretinal

fluid

around

the

tumor

is

absorbed

on

OCT


Fig. 1. Determining retinotopic maps in macaque V1. A. Stimulus grid lines presented in lower right visual quadrant for left hemisphere mapping. Star: fovea location. Grid spacing: 1 degree. Line width: 0.1 deg. Gray area: visual field of the imaged field of view in V1 (illustrated in C). B. Location of imaging window (gray disk) on left hemisphere of a macaque brain. Red and green lines correspond to horizontal and vertical grid lines, respectively. L.S.: lunate sulcus. C-F: Cortical images obtained from an imaging window over V1 and V2 (gray disk in B). C. Summary of visual maps imaged in E and F. Surface blood vessel map with imaged retinotopic lines overlaid. Red and green lines correspond to those shown in A. Fovea is out of the window to the left. D. Ocular dominance map (left eye minus right eye subtraction map) illustrating V1/V2 border. A: anterior, L: lateral, applies to C-F. E. A subtraction map of two horizontal grids having 90° phase difference. F. A subtraction map of two vertical grids having 90° phase difference. Scale bar in F: 2 mm applies to C-F. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)

Fig

Determining

retinotopic

maps

in

macaque

A.

Stimulus

grid

lines

presented

in

lower

right

visual

quadrant

for

left

hemisphere

mapping

Star

fovea

location

Grid

spacing

degree

Line

width

deg

Gray

area

visual

field

of

the

imaged

field

of

view

in

illustrated

in

C

B.

Location

of

imaging

window

gray

disk

on

left

hemisphere

of

a

macaque

brain

Red

and

green

lines

correspond

to

horizontal

and

vertical

grid

lines

respectively

L.S.

lunate

sulcus

C

F

Cortical

images

obtained

from

an

imaging

window

over

and

gray

disk

in

B

C.

Summary

of

visual

maps

imaged

in

E

and

F.

Surface

blood

vessel

map

with

imaged

retinotopic

lines

overlaid

Red

and

green

lines

correspond

to

those

shown

in

A.

Fovea

is

out

of

the

window

to

the

left

D.

Ocular

dominance

map

left

eye

minus

right

eye

subtraction

map

illustrating

border

A

anterior

L

lateral

applies

to

C

F.

E.

A

subtraction

map

of

two

horizontal

grids

having

phase

difference

F.

A

subtraction

map

of

two

vertical

grids

having

phase

difference

Scale

bar

in

F

mm

applies

to

C

F.

For

interpretation

of

the

references

to

color

in

this

figure

legend

the

reader

is

referred

to

the

web

version

of

this

article


Fig. 3. Defects associated with the Smad4 m4Mag allele. Hematoxylin and eosin-stained sagittal sections of E7.5 embryos are shown. (A) Wild-type gastrulating embryo showing newly formed mesoderm (arrow) and other well patterned structures. (B) Homozygous Smad4 tm1Cxd embryo. (C) Smad4 m4Mag ͞ Smad4 tm1Cxd embryo. (D) Homozygous Smad4 m4Mag embryo. (B-D) Compared with the wild-type E7.5 embryo (A), these mutant embryos are much smaller, with no sign of the initiation of gastrulation or the formation of mesoderm. Also note the disproportionally large cavity between the visceral and parietal endoderm (asterisks). (E) Steady-state level of SMAD4 protein in unmutagenized wild-type ES cells (lane 1) and three mutagenized sibling subclones (lane 2, wild-type for Smad4; lanes 3 and 4, heterozygous for Smad4 m4Mag ). The same blot was stripped and reprobed with an anti-ACTIN antibody to show equal loading of total cellular proteins.

Fig

Defects

associated

with

the

allele

Hematoxylin

and

eosin

stained

sagittal

sections

of

embryos

are

shown

A

Wild

type

gastrulating

embryo

showing

newly

formed

mesoderm

arrow

and

other

well

patterned

structures

B

Homozygous

embryo

C

embryo

D

Homozygous

embryo

B

D

Compared

with

the

wild

type

embryo

A

these

mutant

embryos

are

much

smaller

with

no

sign

of

the

initiation

of

gastrulation

or

the

formation

of

mesoderm

Also

note

the

disproportionally

large

cavity

between

the

visceral

and

parietal

endoderm

asterisks

E

Steady

state

level

of

protein

in

unmutagenized

wild

type

ES

cells

lane

and

three

mutagenized

sibling

subclones

lane

wild

type

for

lanes

and

heterozygous

for

The

same

blot

was

stripped

and

reprobed

with

an

anti

ACTIN

antibody

to

show

equal

loading

of

total

cellular

proteins


Figure 3: A 72‑year‑old female patient with a symptomatic carotid stenosis. Ultrasound examination showed: (a and b) Soft‑tissue mass, vascularized, with sonographic findings suggestive of thyroid tissue, located just above the geniohyoid muscle in the sublingual and suprahyoid space. (c) With convex‑array scanner, in more cranial and posterior position, at the level of the tongue base, there is a hypoechoic oval mass indicate a lingual thyroid.

Figure

A

female

patient

with

a

symptomatic

carotid

stenosis

Ultrasound

examination

showed

a

and

b

Soft‑tissue

mass

vascularized

with

sonographic

findings

suggestive

of

thyroid

tissue

located

just

above

the

geniohyoid

muscle

in

the

sublingual

and

suprahyoid

space

c

With

convex‑array

scanner

in

more

cranial

and

posterior

position

at

the

level

of

the

tongue

base

there

is

a

hypoechoic

oval

mass

indicate

a

lingual

thyroid


Figure 3. Magnetic resonance imaging of the cervical spine. ''A'' is T2 sagittal acquisition; ''B'' is T1 post-gadolinium sagittal acquisition. White open arrow in ''A'' shows phlegmon or abscess within the prevertebral space between C1 and C6. White long arrow in ''A'' shows involvement of C6 vertebral body, likely representing osteomyelitis. White short arrow in ''A'' shows signal abnormality in the spinal cord, representing edema. White arrows in ''B'' show enhancement of the posterior aspect of the cervical epidural space between C4 and T2.

Figure

Magnetic

resonance

imaging

of

the

cervical

spine

A

is

sagittal

acquisition

B

is

post

gadolinium

sagittal

acquisition

White

open

arrow

in

A

shows

phlegmon

or

abscess

within

the

prevertebral

space

between

and

White

long

arrow

in

A

shows

involvement

of

vertebral

body

likely

representing

osteomyelitis

White

short

arrow

in

A

shows

signal

abnormality

in

the

spinal

cord

representing

edema

White

arrows

in

B

show

enhancement

of

the

posterior

aspect

of

the

cervical

epidural

space

between

and


Figure 2 Foveal detachment from focal vitreoretinal adherence visualized with en face OCT. (a) En face longitudinal B-scan showing a dome-shaped non-reflective space under the fovea associated with loss of foveal contour and focal foveolar hyaloidal attachment (arrow). (b, c) Left, overlaid red-free coronal C-scan image; right, OCT C-scan. Consecutive anteroposterior C-scans. Angular size, 20 Â 201. The sigmoid hyperreflective band and its relationships with the vascular arcades and the fovea are clearly detectable (arrow). (d) Left, red-free image; right, OCT C-scan. The hyporeflective circle represents the subretinal fluid. It is surrounded by the hyper-reflective ringshaped signal coming from the edges of the detachment. (e) Overlay of image b and c provides a global view of the vitreoretinal adherences.

Figure

Foveal

detachment

from

focal

vitreoretinal

adherence

visualized

with

en

face

OCT

a

En

face

longitudinal

B

scan

showing

a

dome

shaped

non

reflective

space

under

the

fovea

associated

with

loss

of

foveal

contour

and

focal

foveolar

hyaloidal

attachment

arrow

b

c

Left

overlaid

red

free

coronal

C

scan

image

right

OCT

C

scan

Consecutive

anteroposterior

C

scans

Angular

size

Â

The

sigmoid

hyperreflective

band

and

its

relationships

with

the

vascular

arcades

and

the

fovea

are

clearly

detectable

arrow

d

Left

red

free

image

right

OCT

C

scan

The

hyporeflective

circle

represents

the

subretinal

fluid

It

is

surrounded

by

the

hyper

reflective

ringshaped

signal

coming

from

the

edges

of

the

detachment

e

Overlay

of

image

b

and

c

provides

a

global

view

of

the

vitreoretinal

adherences


Fig. 1. a. Chest radiograph on admission, showing consolidation in the upper field of the left lung and an infiltration shadow in the middle and lower fields of the left lung. b. Chest CT on admission, showing bullae and emphysema in the right lung and consolidation in pulmonary bullae adjacent to the aortic arch in the left lung.

Fig

a.

Chest

radiograph

on

admission

showing

consolidation

in

the

upper

field

of

the

left

lung

and

an

infiltration

shadow

in

the

middle

and

lower

fields

of

the

left

lung

b.

Chest

CT

on

admission

showing

bullae

and

emphysema

in

the

right

lung

and

consolidation

in

pulmonary

bullae

adjacent

to

the

aortic

arch

in

the

left

lung


Figure 1. Grade I RPOH in a 69 years old male patient: AP (A) and axial (B) views of the left hip show partial joint space narrowing and clearly visible geodes in both the acetabulum and femoral head, creating and inhomogeneous aspect. The femoral head is not deformed or ascended.

Figure

Grade

I

RPOH

in

a

years

old

male

patient

AP

A

and

axial

B

views

of

the

left

hip

show

partial

joint

space

narrowing

and

clearly

visible

geodes

in

both

the

acetabulum

and

femoral

head

creating

and

inhomogeneous

aspect

The

femoral

head

is

not

deformed

or

ascended


Fig. 6. FeSEM of isolated nuclear envelopes from oocytes expressing high levels of lamin A after injection of 1.5 ng of plasmid DNA. (A,B) Lamin A filaments that are arranged in layered bundles are indicated by small arrows; they surround, but appear not to interact with, structures that are consistent with NPC baskets. In general, the distal basket ring is visible (large arrows), and sometimes basket filaments can be seen (arrowheads). Oocytes expressing lamin A were also analysed by TEM thin sections and compared with controls. (C,D) The lamina is hardly discernible in (C) controls but forms a thick electron-dense layer in (D) oocytes expressing lamin A, which leaves the NPCs clear (arrows).

Fig

FeSEM

of

isolated

nuclear

envelopes

from

oocytes

expressing

high

levels

of

lamin

A

after

injection

of

ng

of

plasmid

DNA

A

B

Lamin

A

filaments

that

are

arranged

in

layered

bundles

are

indicated

by

small

arrows

they

surround

but

appear

not

to

interact

with

structures

that

are

consistent

with

NPC

baskets

In

general

the

distal

basket

ring

is

visible

large

arrows

and

sometimes

basket

filaments

can

be

seen

arrowheads

Oocytes

expressing

lamin

A

were

also

analysed

by

TEM

thin

sections

and

compared

with

controls

C

D

The

lamina

is

hardly

discernible

in

C

controls

but

forms

a

thick

electron

dense

layer

in

D

oocytes

expressing

lamin

A

which

leaves

the

NPCs

clear

arrows


Figure 1. Chest X-ray and computed tomography (CT) findings: ground glass o consolidations were found on right middle lung fields (case 1); bilateral multifocal GG pleural effusion (case 3).

Figure

Chest

X

ray

and

computed

tomography

CT

findings

ground

glass

o

consolidations

were

found

on

right

middle

lung

fields

case

bilateral

multifocal

GG

pleural

effusion

case


Fig. 1. Representative cross-sectional images and three-dimensional (3D) renderings of the same bone specimen using microcomputed tomography (lCT) voxel size of 22 lm in each direction) (A) and (C) App. BV/TV = 0.32, (B) and (D) App. BV/ TV = 0.19. App., apparent; BV/TV, bone volume/total volume.

Fig

Representative

cross

sectional

images

and

three

dimensional

renderings

of

the

same

bone

specimen

using

microcomputed

tomography

lCT

voxel

size

of

lm

in

each

direction

A

and

C

App

BV

TV

B

and

D

App

BV/

TV

App

apparent

BV

TV

bone

volume

total

volume


Fig. 5 a Top: T2-weighted MRI of a control mouse implanted with EGFRvIII-expressing orthotopic human GBM xenograft (U87MGEGFRvIII) showing a hyperintense xenograft (white arrows) post tumor implantation. Bottom: Serial T2-weighted MRI of a mouse which underwent implantation of an EGFRvIII-expressing orthotopic human GBM xenograft (U87MGEGFRvIII) and subsequent CED of cetuximab-IONPs. Hypointense MRI signal drop after CED of

Fig

a

Top

MRI

of

a

control

mouse

implanted

with

EGFRvIII

expressing

orthotopic

human

GBM

xenograft

showing

a

hyperintense

xenograft

white

arrows

post

tumor

implantation

Bottom

Serial

MRI

of

a

mouse

which

underwent

implantation

of

an

EGFRvIII

expressing

orthotopic

human

GBM

xenograft

and

subsequent

CED

of

cetuximab

IONPs

Hypointense

MRI

signal

drop

after

CED

of


FIGURE 3 | Scanning electron microscopy (SEM) imaging of Devosia mutans 17-2-E-8 (A) and transmission electron microscopy (TEM) images (B,C) of isolate 17-2-E-8.

FIGURE

Scanning

electron

microscopy

SEM

imaging

of

Devosia

mutans

A

and

transmission

electron

microscopy

TEM

images

B

C

of

isolate


Figure 1. CT scans of a 45-year-old man with small cell carcinoma of the rectum (patient 4). (A) Axial non-enhanced CT scan demonstrating a thickened left wall of the rectum, with patchy low attenuation and the presence of an exophytic mass. Tumor invasion of the prostate glands and seminal vesicle was also observed. (B) Axial contrast-enhanced CT scan demonstrating heterogeneous strong enhancement. (C) Axial CT scan demonstrating the presence of multiple lung metastases. (D) Axial non-enhanced and contrast-enhanced CT scan demonstrating the presence of multiple liver metastases. CT, computed tomography.

Figure

CT

scans

of

a

old

man

with

small

cell

carcinoma

of

the

rectum

patient

A

Axial

non

enhanced

CT

scan

demonstrating

a

thickened

left

wall

of

the

rectum

with

patchy

low

attenuation

and

the

presence

of

an

exophytic

mass

Tumor

invasion

of

the

prostate

glands

and

seminal

vesicle

was

also

observed

B

Axial

contrast

enhanced

CT

scan

demonstrating

heterogeneous

strong

enhancement

C

Axial

CT

scan

demonstrating

the

presence

of

multiple

lung

metastases

D

Axial

non

enhanced

and

contrast

enhanced

CT

scan

demonstrating

the

presence

of

multiple

liver

metastases

CT

computed

tomography


Fig. 1. Magnetic resonance (MR) images. A. Coronal MR image showed a low attenuated on T1-weighted in the ventral tongue. B. A high attenuated on T2-weighted. Thus, we could concluded this lesion is consisted with fluid accumulation. Eun-Jung Kwak et al: Oral foregut cyst in the ventral tongue: a case report. J Korean Assoc Oral Maxillofac Surg 2014

Fig

Magnetic

resonance

MR

images

A.

Coronal

MR

image

showed

a

low

attenuated

on

in

the

ventral

tongue

B.

A

high

attenuated

on

Thus

we

could

concluded

this

lesion

is

consisted

with

fluid

accumulation

Eun

Jung

Kwak

et

al

Oral

foregut

cyst

in

the

ventral

tongue

a

case

report

J

Korean

Assoc

Oral

Maxillofac

Surg