Fig. 1 A 43-year-old female with stenosis of the subclavian artery (arrow) and vein (arrowhead) when arms are elevated. Targeted maximum intensity projection of CE-MRA shows strong selective arterial enhancement during first pass of gadofosvesit trisodium (0.03 mmol/kg @ 0.8 ml/s) (a) and prolonged arterial/venous enhancement during steady state (b). Moreover, the long time window of vascular enhancement allows steady-state imaging with arms down (c), showing release of the arterial and venous compression. (Courtesy of Dr. Heyder, Grabs, Switzerland)

Fig

A

old

female

with

stenosis

of

the

subclavian

artery

arrow

and

vein

arrowhead

when

arms

are

elevated

Targeted

maximum

intensity

projection

of

CE

MRA

shows

strong

selective

arterial

enhancement

during

first

pass

of

gadofosvesit

trisodium

mmol

kg

ml

s

a

and

prolonged

arterial

venous

enhancement

during

steady

state

b

Moreover

the

long

time

window

of

vascular

enhancement

allows

steady

state

imaging

with

arms

down

c

showing

release

of

the

arterial

and

venous

compression

Courtesy

of

Dr.

Heyder

Grabs

Switzerland


Figure 3. Axial CT (A), axial (B), and sagittal (C) T2-weighted MR images showing microcephaly and skull collapse. There is moderate ventricular dilatation, enlargement of extra-axial cerebrospinal fluid spaces and thinning of brain parenchyma. The gyral pattern is abnormally smooth for gestational age. Subcortical calcifications are predominantly located in the frontal lobes. Axial (D) and (E) T2-weighted, and coronal (F) T1-weighted follow-up MR images registered at 16- month-old showing the same pattern observed at birth.

Figure

Axial

CT

A

axial

B

and

sagittal

C

MR

images

showing

microcephaly

and

skull

collapse

There

is

moderate

ventricular

dilatation

enlargement

of

extra

axial

cerebrospinal

fluid

spaces

and

thinning

of

brain

parenchyma

The

gyral

pattern

is

abnormally

smooth

for

gestational

age

Subcortical

calcifications

are

predominantly

located

in

the

frontal

lobes

Axial

D

and

E

and

coronal

F

follow

up

MR

images

registered

at

month

old

showing

the

same

pattern

observed

at

birth


Figure 1. Mycetoma of the foot from Nocardia brasiliensis showing the characteristic triad of tumefaction, fistulae and microcolonies. Central image, an X-ray analysis of the ankle and foot region showing the severe destruction of bones. Right image, a microcolony of N. brasiliensis stained with PAS surrounded by a PMN infiltrate. doi:10.1371/journal.pone.0065425.g001

Figure

Mycetoma

of

the

foot

from

Nocardia

brasiliensis

showing

the

characteristic

triad

of

tumefaction

fistulae

and

microcolonies

Central

image

an

X

ray

analysis

of

the

ankle

and

foot

region

showing

the

severe

destruction

of

bones

Right

image

a

microcolony

of

N.

brasiliensis

stained

with

PAS

surrounded

by

a

PMN

infiltrate


Figure 1: A representative case of low-grade uterine endometrial stromal sarcoma (L-ESS, 58-y-old patient, FIGO stage I). T2-weighted (A) and contrast-enhanced T1-weighted (B) MR images and 18 F-FDG (C) and 18 F-FES (D) PET images are shown. The 18 F-FDG SUV, 18 F-FES SUV, and 18 F-FDG/ 18 F-FES SUV ratio were 5.4, 12.6, and 0.4, respectively. Immunohistochemistry revealed that ER expression (E) was high and MIB-1 expression (F) was low in this case. The patient underwent an abdominal total hysterectomy with bilateral salpingo-oophorectomy (TAH + BSO) and is still alive without any recurrence or metastasis.

Figure

A

representative

case

of

low

grade

uterine

endometrial

stromal

sarcoma

L

ESS

old

patient

FIGO

stage

I

A

and

contrast

enhanced

B

MR

images

and

F

FDG

C

and

F

FES

D

PET

images

are

shown

The

F

FDG

SUV

F

FES

SUV

and

F

FDG/

F

FES

SUV

ratio

were

and

respectively

Immunohistochemistry

revealed

that

ER

expression

E

was

high

and

expression

F

was

low

in

this

case

The

patient

underwent

an

abdominal

total

hysterectomy

with

bilateral

salpingo

oophorectomy

TAH

BSO

and

is

still

alive

without

any

recurrence

or

metastasis


Figure 1: (a) CT of the abdomen coronal and axial views. A complex mass with foci of calcification in gallbladder fossa and 9 cm heterogeneous mass in the right hepatic lobe. (b) MRI of the abdomen axial view: large gallbladder complex mass of 5 × 4 cm with engulfed calcifications and stones extending into the liver. 9 cm liver mass with some central necrosis and calcifications and loss of clear fat plane separation between the gallbladder and right liver, associated with large hilar lymphadenopathy (4 × 5 cm) and compressive effects on the distal biliary system.

Figure

a

CT

of

the

abdomen

coronal

and

axial

views

A

complex

mass

with

foci

of

calcification

in

gallbladder

fossa

and

cm

heterogeneous

mass

in

the

right

hepatic

lobe

b

MRI

of

the

abdomen

axial

view

large

gallbladder

complex

mass

of

cm

with

engulfed

calcifications

and

stones

extending

into

the

liver

cm

liver

mass

with

some

central

necrosis

and

calcifications

and

loss

of

clear

fat

plane

separation

between

the

gallbladder

and

right

liver

associated

with

large

hilar

lymphadenopathy

cm

and

compressive

effects

on

the

distal

biliary

system


Fig. 5. In vivo imaging after implantation of HeyA8-GFP cells. a) Single cells (week 1). b) Small cluster of cells (week 2). c) Bulk tumor mass (week 3). d) Neovasculature detected as branching, non-fluorescent structures within a GFP-positive tumor (week 4).

Fig

In

vivo

imaging

after

implantation

of

cells

a

Single

cells

week

b

Small

cluster

of

cells

week

c

Bulk

tumor

mass

week

d

Neovasculature

detected

as

branching

non

fluorescent

structures

within

a

GFP

positive

tumor

week


Figure 2. ‘‘Malignant’’ bone formation within the tumour mass after SaOS-2 transplantation. A, Representative CT image 70 days after intrafemoral transplantation of SaOS-2 cells showing ‘‘malignant’’ bone formation within the extraosseous tumour mass (arrow). B, Representative Maximum Intensity Projection CT image of a mouse bearing a SaOS tumour 70 days after transplantation, showing ‘‘malignant’’ bone formation within the extraosseous tumour mass (arrow). C, ‘‘Malignant’’ bone forming amongst tumour cells in the medullary cavity, showing appositional deposition (scaffolding) on existing bone trabeculae (‘‘T’’) (H&E, original magnification 2006). D, Left panel: malignant tumour cells amongst pale eosinophilic osteoid which is partially mineralised (arrow) (H&E, original magnification 4006). Right panel: fine, randomly arborising strands of mineralised osteoid (‘‘malignant’’ bone) amongst SaOS-2 tumour cells (H&E, original magnification 4006). doi:10.1371/journal.pone.0085128.g002

Figure

Malignant

bone

formation

within

the

tumour

mass

after

transplantation

A

Representative

CT

image

days

after

intrafemoral

transplantation

of

cells

showing

malignant

bone

formation

within

the

extraosseous

tumour

mass

arrow

B

Representative

Maximum

Intensity

Projection

CT

image

of

a

mouse

bearing

a

SaOS

tumour

days

after

transplantation

showing

malignant

bone

formation

within

the

extraosseous

tumour

mass

arrow

C

Malignant

bone

forming

amongst

tumour

cells

in

the

medullary

cavity

showing

appositional

deposition

scaffolding

on

existing

bone

trabeculae

T

H&E

original

magnification

D

Left

panel

malignant

tumour

cells

amongst

pale

eosinophilic

osteoid

which

is

partially

mineralised

arrow

H&E

original

magnification

Right

panel

fine

randomly

arborising

strands

of

mineralised

osteoid

malignant

bone

amongst

tumour

cells

H&E

original

magnification


Figure 1: (a) Brain computed tomography before thrombolysis. Old infarction in the left basal ganglia. The patient fulfilled the criteria of SITS-MOST for intravenous recombinant tissue plasminogen activator. (b) Brain computed tomography, carried out 24 h after thrombolysis with hemorrhage type 2 in the area of infarction in the left posterior MCA (middle cerebral artery), with clinical worsening. (c) Brain computed tomography after thrombolysis small hemorrhagic transformation (HI-2) without clinical worsening c b a

Figure

a

Brain

computed

tomography

before

thrombolysis

Old

infarction

in

the

left

basal

ganglia

The

patient

fulfilled

the

criteria

of

SITS

MOST

for

intravenous

recombinant

tissue

plasminogen

activator

b

Brain

computed

tomography

carried

out

h

after

thrombolysis

with

hemorrhage

type

in

the

area

of

infarction

in

the

left

posterior

MCA

middle

cerebral

artery

with

clinical

worsening

c

Brain

computed

tomography

after

thrombolysis

small

hemorrhagic

transformation

without

clinical

worsening

c

b

a


Figure 1. (a) X-ray of the abdomen while the patient was standing. An air-fluid level can be seen (white arrow). (b) Computed tomographic scan of the abdomen performed with intravenous contrast material. Part of the mesentery in the middle part of the abdomen is swirled with mesangial thickening, and mesentery and adipose tissue encapsulate mesenteric vessels. Exudation surrounds the mesenteric soft tissue mass in the middle of the abdomen (red arrow) and there are scattered lymph nodes in this mass (blue arrow). Branches of the superior mesenteric artery and tributaries of the superior mesenteric vein in the mesenteric soft tissue mass can be seen (the cavity of all of these vessels is not narrow) (thin white arrow). (c) Stones in the bile duct were taken out after performing endoscopic retrograde cholangiopancreatography. (d) Computed tomographic scan of the abdomen performed with intravenous contrast material, which was performed 4 weeks after the scan shown in panel B, shows a mesenteric soft tissue mass (11.6 6.8 cm). Part of the mesentery in the middle part of the abdomen is swirled with mesangial thickening and increased density of the mesentery. The mesentery and adipose tissue encapsulate mesenteric vessels. The surrounding exudation is more aggravated than previously observed (red arrow). There are scattered lymph nodes in the mesenteric soft tissue mass (blue arrow) and a pseudocapsule has formed around this mass (thick white arrow). Branches of the superior mesenteric artery and tributaries of the superior mesenteric vein in the mesenteric soft tissue mass can be seen (the cavity of all of these vessels is not narrow) (thin white arrow). (e) Computed tomographic scan of the abdomen performed with intravenous contrast material at discharge shows a reduction in size of the mesenteric soft tissue mass (6.8 5.0 cm). Exudation of the mesenteric soft tissue mass is greatly reduced (red arrows) and the pseudocapsule still remains (thick white arrow). Branches of the superior mesenteric artery and tributaries of the superior mesenteric vein in the mesenteric soft tissue mass can be seen (the cavity of all of these vessels is not narrow) (thin white arrow)

Figure

a

X

ray

of

the

abdomen

while

the

patient

was

standing

An

air

fluid

level

can

be

seen

white

arrow

b

Computed

tomographic

scan

of

the

abdomen

performed

with

intravenous

contrast

material

Part

of

the

mesentery

in

the

middle

part

of

the

abdomen

is

swirled

with

mesangial

thickening

and

mesentery

and

adipose

tissue

encapsulate

mesenteric

vessels

Exudation

surrounds

the

mesenteric

soft

tissue

mass

in

the

middle

of

the

abdomen

red

arrow

and

there

are

scattered

lymph

nodes

in

this

mass

blue

arrow

Branches

of

the

superior

mesenteric

artery

and

tributaries

of

the

superior

mesenteric

vein

in

the

mesenteric

soft

tissue

mass

can

be

seen

the

cavity

of

all

of

these

vessels

is

not

narrow

thin

white

arrow

c

Stones

in

the

bile

duct

were

taken

out

after

performing

endoscopic

retrograde

cholangiopancreatography

d

Computed

tomographic

scan

of

the

abdomen

performed

with

intravenous

contrast

material

which

was

performed

weeks

after

the

scan

shown

in

panel

B

shows

a

mesenteric

soft

tissue

mass

cm

Part

of

the

mesentery

in

the

middle

part

of

the

abdomen

is

swirled

with

mesangial

thickening

and

increased

density

of

the

mesentery

The

mesentery

and

adipose

tissue

encapsulate

mesenteric

vessels

The

surrounding

exudation

is

more

aggravated

than

previously

observed

red

arrow

There

are

scattered

lymph

nodes

in

the

mesenteric

soft

tissue

mass

blue

arrow

and

a

pseudocapsule

has

formed

around

this

mass

thick

white

arrow

Branches

of

the

superior

mesenteric

artery

and

tributaries

of

the

superior

mesenteric

vein

in

the

mesenteric

soft

tissue

mass

can

be

seen

the

cavity

of

all

of

these

vessels

is

not

narrow

thin

white

arrow

e

Computed

tomographic

scan

of

the

abdomen

performed

with

intravenous

contrast

material

at

discharge

shows

a

reduction

in

size

of

the

mesenteric

soft

tissue

mass

cm

Exudation

of

the

mesenteric

soft

tissue

mass

is

greatly

reduced

red

arrows

and

the

pseudocapsule

still

remains

thick

white

arrow

Branches

of

the

superior

mesenteric

artery

and

tributaries

of

the

superior

mesenteric

vein

in

the

mesenteric

soft

tissue

mass

can

be

seen

the

cavity

of

all

of

these

vessels

is

not

narrow

thin

white

arrow


FIGURE 5 Indirect immunofluorescence of Schwann cel l -nerve cell cultures with anti-PG1 monoclonal antibody. Cultures grown in N2 for 4 wk were keep in N2 medium (A) or switched to N2FA medium (B). After 5 d, the cultures were processed for indirect immunofluorescence using the mouse monoclonal ant ibody B3 which was shown to recognize PG1 (see Fig. 4). The nuclear fluorescence in both micrographs is not due to the ant ibody (not shown). Note in the N2FA culture (B) the linear extracellular staining pattern characteristic of Schwann cell basal lamina staining. The inset in B shows an N2FA culture stained with ant icollagen IV antiserum. This antiserum does not stain N2 cultures (not shov :l). Both specimens were prepared for immunofluorescence, photographed, and printed under identical conditions, x 490.

FIGURE

Indirect

immunofluorescence

of

Schwann

cel

l

-nerve

cell

cultures

with

anti

monoclonal

antibody

Cultures

grown

in

for

wk

were

keep

in

medium

A

or

switched

to

medium

B

After

d

the

cultures

were

processed

for

indirect

immunofluorescence

using

the

mouse

monoclonal

ant

ibody

which

was

shown

to

recognize

see

Fig

The

nuclear

fluorescence

in

both

micrographs

is

not

due

to

the

ant

ibody

not

shown

Note

in

the

culture

B

the

linear

extracellular

staining

pattern

characteristic

of

Schwann

cell

basal

lamina

staining

The

inset

in

B

shows

an

culture

stained

with

ant

icollagen

IV

antiserum

This

antiserum

does

not

stain

cultures

not

shov

l

Both

specimens

were

prepared

for

immunofluorescence

photographed

and

printed

under

identical

conditions

x


FIGURE 6. Transverse cross-section through rod area of phantom filled with 124I solution. Images without (A) and with (B) scatter correction are shown. Scatter-corrected image clearly displays ellipsoid deformation.

FIGURE

Transverse

cross

section

through

rod

area

of

phantom

filled

with

solution

Images

without

A

and

with

B

scatter

correction

are

shown

Scatter

corrected

image

clearly

displays

ellipsoid

deformation


Figure 5. A non-smoking woman with lung adenocarcinoma in the left upper lobe, where PCR images (A) and pathological picture (D) show that the subtype is exon 21 mutation. CT images (B,C) show a subsolid lump with spiculated margins.

Figure

A

non

smoking

woman

with

lung

adenocarcinoma

in

the

left

upper

lobe

where

PCR

images

A

and

pathological

picture

D

show

that

the

subtype

is

exon

mutation

CT

images

B

C

show

a

subsolid

lump

with

spiculated

margins


Fig. 2 Initial T 1 -weighted magnetic resonance (MR) images with gadolinium showing an enhanced tumor measuring 5 cm in diameter attached to the left frontal base on the axial image (A), and on the coronal image (B). Follow-up T 1 -weighted MR images with gadolinium showing remarkable regression of the tumor at 2 years 9 months after the initial presentation (C, D).

Fig

Initial

T

-weighted

magnetic

resonance

MR

images

with

gadolinium

showing

an

enhanced

tumor

measuring

cm

in

diameter

attached

to

the

left

frontal

base

on

the

axial

image

A

and

on

the

coronal

image

B

Follow

up

T

-weighted

MR

images

with

gadolinium

showing

remarkable

regression

of

the

tumor

at

years

months

after

the

initial

presentation

C

D


Fig. 8 Urachal carcinoma with invasion of the small bowel. a Abdominal radiograph after instillation of contrast into the bladder shows a vesicoenteric fistula (arrow) with filling of multiple small bowel loops. b Axial CT image shows both enteric contrast and gas within the tumor

Fig

Urachal

carcinoma

with

invasion

of

the

small

bowel

a

Abdominal

radiograph

after

instillation

of

contrast

into

the

bladder

shows

a

vesicoenteric

fistula

arrow

with

filling

of

multiple

small

bowel

loops

b

Axial

CT

image

shows

both

enteric

contrast

and

gas

within

the

tumor


Fig. 3 Incomplete treatment due to extrahepatic tumor blood supply. Axial contrast-enhanced CT scan (a) demonstrates segment 7 hepatocellular carcinoma (arrowheads). Arteriogram (b) shows hypervascular tumor (arrows). However, note absent perfusion along posteromedial margin (arrowheads), which was unnoticed prior to 90 Y RE. Posttreatment axial contrast-enhanced CT scan (c) displays partial tumor response, with persistent viable tumor enhancement (asterisk). Arteriogram performed during retreatment (d) reveals tumor blood supply (arrowheads) via inferior phrenic artery, which was treated with transarterial chemoembolization.

Fig

Incomplete

treatment

due

to

extrahepatic

tumor

blood

supply

Axial

contrast

enhanced

CT

scan

a

demonstrates

segment

hepatocellular

carcinoma

arrowheads

Arteriogram

b

shows

hypervascular

tumor

arrows

However

note

absent

perfusion

along

posteromedial

margin

arrowheads

which

was

unnoticed

prior

to

Y

RE

Posttreatment

axial

contrast

enhanced

CT

scan

c

displays

partial

tumor

response

with

persistent

viable

tumor

enhancement

asterisk

Arteriogram

performed

during

retreatment

d

reveals

tumor

blood

supply

arrowheads

via

inferior

phrenic

artery

which

was

treated

with

transarterial

chemoembolization


Figure 10 (bottom): Aborted male fetus at 20 weeks of gestation with congenital high airway obstruction syndrome: Findings: Contrast radiograph of upper airways in (a) lateral and (b) antero-posterior views depicting normal contrast filling of the pharynx with abrupt distal cut off (yellow arrow). Technique: Contrast (Iohexol). KonicaMinolta Aero DR System. 53kV, 6mAS.

Figure

bottom

Aborted

male

fetus

at

weeks

of

gestation

with

congenital

high

airway

obstruction

syndrome

Findings

Contrast

radiograph

of

upper

airways

in

a

lateral

and

b

antero

posterior

views

depicting

normal

contrast

filling

of

the

pharynx

with

abrupt

distal

cut

off

yellow

arrow

Technique

Contrast

Iohexol

KonicaMinolta

Aero

DR

System


FIGURE 3 | The two fiber tracts, CST and Fminor, subject to quantitative analysis. (A) The corticospinal tract (CST ) in one of the subjects, extracted by using one ROI (pink surface) on the cerebral peduncle at the level of the decussation of the superior cerebellar peduncle (DSCP) and one ROI (green surface) at the central sulcus (CS) after the bifurcation to the motor and sensory cortex. (B) The forceps minor (Fminor) in one of the subjects, extracted in a coronal slice by using two ROIs (pink and brown surfaces) at the mid-point between the anterior tip of the frontal lobe and the anterior edge of the genu of the corpus callosum (indicated with short white arrows), in each hemisphere.

FIGURE

The

two

fiber

tracts

CST

and

Fminor

subject

to

quantitative

analysis

A

The

corticospinal

tract

CST

in

one

of

the

subjects

extracted

by

using

one

ROI

pink

surface

on

the

cerebral

peduncle

at

the

level

of

the

decussation

of

the

superior

cerebellar

peduncle

DSCP

and

one

ROI

green

surface

at

the

central

sulcus

CS

after

the

bifurcation

to

the

motor

and

sensory

cortex

B

The

forceps

minor

Fminor

in

one

of

the

subjects

extracted

in

a

coronal

slice

by

using

two

ROIs

pink

and

brown

surfaces

at

the

mid

point

between

the

anterior

tip

of

the

frontal

lobe

and

the

anterior

edge

of

the

genu

of

the

corpus

callosum

indicated

with

short

white

arrows

in

each

hemisphere


Fig. 4. Selected magnifications of nuclear sections. Exponential (a) and stationary (b) phase nuclei are depicted. The arrows indicate the presence of heterochromatin, the nucleoli (No) are also indicated.

Fig

Selected

magnifications

of

nuclear

sections

Exponential

a

and

stationary

b

phase

nuclei

are

depicted

The

arrows

indicate

the

presence

of

heterochromatin

the

nucleoli

No

are

also

indicated


Fig. 2 (Left panel): CT images on dorsal plane: 1) Cerebrum; 8) Maxillary bone; 9) Ethmoid; 16) Nasal septum; 17) Septum of the maxillary sinus; 19) Rostral maxillary sinus; 20) Caudal maxillary sinus; 23) Ventral nasal concha; 26) Common nasal meatus; 28) Infraorbital canal. (Right panel): CT image on median sagittal plane: 1) Dorsal nasal meatus; 2) Ventral nasal meatus; 3) Middle nasal meatus; 4) Conchofrontal sinus; 7) Sphenopalatine sinus; 8) Dorsal nasal concha; 9) Ventral nasal concha; 12) Nasopharynx; 14) Ethmoid; 16) Nasal bone; 17) Frontal bone; 25) Cerebrum; 26) Pre-sphenoid

Fig

Left

panel

CT

images

on

dorsal

plane

Cerebrum

Maxillary

bone

Ethmoid

Nasal

septum

Septum

of

the

maxillary

sinus

Rostral

maxillary

sinus

Caudal

maxillary

sinus

Ventral

nasal

concha

Common

nasal

meatus

Infraorbital

canal

Right

panel

CT

image

on

median

sagittal

plane

Dorsal

nasal

meatus

Ventral

nasal

meatus

Middle

nasal

meatus

Conchofrontal

sinus

Sphenopalatine

sinus

Dorsal

nasal

concha

Ventral

nasal

concha

Nasopharynx

Ethmoid

Nasal

bone

Frontal

bone

Cerebrum

Pre

sphenoid


Figure 7. Electron micrographs demonstrating the prevention of perivascular edema, demyelination/axon loss, and neuronal apoptosis/necrosis in the rat EAE model by PMSC and P + C + A treatment. (A,B) Normal control rats. (A) normal myelinated axons exhibiting dark, ring-shaped myelin sheaths surrounding axons, (B) normal neuronal nuclei with uncondensed chromatin. (C–G) Vehicle-treated EAE rats at 3 weeks pi. (C) myelin sheath displaying splitting, vacuoles, loose and fused changes, and shrunken, atrophied axons, (D,E) tissue edema (D) and severe blood vessel leakage (E, arrow) detected in the extracellular space surrounding the vessels, (F) a neuron showing signs of apoptosis with a shrunken nucleus and condensed, fragmented, and marginated nuclear chromatin, (G) an extravasated inflammatory cell in tissue edema. (H–K) PMSC- (H,I) and P + C + A- (J,K) treated EAE rats at 3 weeks pi. Myelin sheath splitting, axonal loss, and perivascular edema were reduced, and neuron nuclei displayed relatively normal morphology. (L–N) Vehicle-treated EAE rats at 8 weeks pi. Many myelin lamellae were still undergoing vesicular disintegration and demyelination (L), with some fibers being completely lost or only showing an empty circle of remaining myelin (arrow in L). Perivascular

Figure

Electron

micrographs

demonstrating

the

prevention

of

perivascular

edema

demyelination

axon

loss

and

neuronal

apoptosis

necrosis

in

the

rat

EAE

model

by

PMSC

and

P

C

A

treatment

A

B

Normal

control

rats

A

normal

myelinated

axons

exhibiting

dark

ring

shaped

myelin

sheaths

surrounding

axons

B

normal

neuronal

nuclei

with

uncondensed

chromatin

C

G

Vehicle

treated

EAE

rats

at

weeks

pi

C

myelin

sheath

displaying

splitting

vacuoles

loose

and

fused

changes

and

shrunken

atrophied

axons

D

E

tissue

edema

D

and

severe

blood

vessel

leakage

E

arrow

detected

in

the

extracellular

space

surrounding

the

vessels

F

a

neuron

showing

signs

of

apoptosis

with

a

shrunken

nucleus

and

condensed

fragmented

and

marginated

nuclear

chromatin

G

an

extravasated

inflammatory

cell

in

tissue

edema

H

K

PMSC-

H

I

and

P

C

A-

J

K

treated

EAE

rats

at

weeks

pi

Myelin

sheath

splitting

axonal

loss

and

perivascular

edema

were

reduced

and

neuron

nuclei

displayed

relatively

normal

morphology

L

N

Vehicle

treated

EAE

rats

at

weeks

pi

Many

myelin

lamellae

were

still

undergoing

vesicular

disintegration

and

demyelination

L

with

some

fibers

being

completely

lost

or

only

showing

an

empty

circle

of

remaining

myelin

arrow

in

L

Perivascular


Fig. 1. – a) Chest radiograph in October 1998 showing paratracheal enlargement of the mediastinum to the right. b) Computed tomography scan of the neck showing cervical abscesses (December 1998).

Fig

a

Chest

radiograph

in

October

showing

paratracheal

enlargement

of

the

mediastinum

to

the

right

b

Computed

tomography

scan

of

the

neck

showing

cervical

abscesses

December


Fig. 1 Pre and postoperative magnetic resonance imaging (MRI) and computed tomography (CT) studies of the right sided vestibular schwannoma, occupying the cerebellopontine cistern and reaching the cerebral peduncle with early signs of compression.

Fig

Pre

and

postoperative

magnetic

resonance

imaging

MRI

and

computed

tomography

CT

studies

of

the

right

sided

vestibular

schwannoma

occupying

the

cerebellopontine

cistern

and

reaching

the

cerebral

peduncle

with

early

signs

of

compression


Figure 3. Staging positron emission tomography/CT fusion (left) and CT images (right) showing abdominal and peritoneal masses.

Figure

Staging

positron

emission

tomography

CT

fusion

left

and

CT

images

right

showing

abdominal

and

peritoneal

masses


Figure 2. PPT1 and Rab3IP are detected in cilia. MEFs were immunostained by anti-acetylated tubulin antibodies, using anti-mouse Alexa 488 as secondary antibodies (A), anti-PPT1 antibodies using anti rabbit Alexa 647 as secondary antibodies (B) and anti-Rab3IP antibodies using anti-goat CY3 as secondary antibodies (C). Both PPT1 and Rab3IP colocalize with acetylated tubulin (D,F) and with each other (E,G). Nuclei are stained by DAPI represented by the blue channel. Scale bar 5mm. Imaging was conducted by super-resolution microscopy.

Figure

and

are

detected

in

cilia

MEFs

were

immunostained

by

anti

acetylated

tubulin

antibodies

using

anti

mouse

Alexa

as

secondary

antibodies

A

anti

antibodies

using

anti

rabbit

Alexa

as

secondary

antibodies

B

and

anti

antibodies

using

anti

goat

as

secondary

antibodies

C

Both

and

colocalize

with

acetylated

tubulin

D

F

and

with

each

other

E

G

Nuclei

are

stained

by

DAPI

represented

by

the

blue

channel

Scale

bar

mm

Imaging

was

conducted

by

super

resolution

microscopy


Figure 1. A: Chest X-ray showing infiltrative shadows and GGO in the right middle and lower lung fields and in the left lower lung field. B: Chest CT revealing GGO and consolidation with subpleural reticulonodular lesions in the bilateral lower lobes. C: Chest HRCT showing reversed halo sign and consolidation in the left lower lobe.

Figure

A

Chest

X

ray

showing

infiltrative

shadows

and

GGO

in

the

right

middle

and

lower

lung

fields

and

in

the

left

lower

lung

field

B

Chest

CT

revealing

GGO

and

consolidation

with

subpleural

reticulonodular

lesions

in

the

bilateral

lower

lobes

C

Chest

HRCT

showing

reversed

halo

sign

and

consolidation

in

the

left

lower

lobe


Figure 1. A 35-year-old man with anterior and posterior pelvic ring injuries (Tile type C1) caused by a traffic accident. (a, b) Preoperative plain X-ray film and three-dimensional computed tomography image showed bilateral pubic ramus fractures combined with an avulsion fracture of the left posterior superior iliac spine. The red arrow shows the dorsal fracture. (c) Anterior surgical incisions for modified internal fixation. (d) Three screws at both the anterior inferior iliac spine and pubic tubercle constituted a geometric triangle. (e) Postoperative plain X-ray film showed good reduction after performance of anterior modified internal fixation using a posterior transiliac internal fixator. (f) One-year postoperative plain X-ray film showed fracture healing as evidenced by progressive callus formation.

Figure

A

old

man

with

anterior

and

posterior

pelvic

ring

injuries

Tile

type

caused

by

a

traffic

accident

a

b

Preoperative

plain

X

ray

film

and

three

dimensional

computed

tomography

image

showed

bilateral

pubic

ramus

fractures

combined

with

an

avulsion

fracture

of

the

left

posterior

superior

iliac

spine

The

red

arrow

shows

the

dorsal

fracture

c

Anterior

surgical

incisions

for

modified

internal

fixation

d

Three

screws

at

both

the

anterior

inferior

iliac

spine

and

pubic

tubercle

constituted

a

geometric

triangle

e

Postoperative

plain

X

ray

film

showed

good

reduction

after

performance

of

anterior

modified

internal

fixation

using

a

posterior

transiliac

internal

fixator

f

One

year

postoperative

plain

X

ray

film

showed

fracture

healing

as

evidenced

by

progressive

callus

formation


Fig. 2 a Manual muscle segmentation of ST = semitendinosus (yellow), RF = rectus femoris (red), CS = cranial sartorius (light blue), AD = adductor magnus (blue), GR = gracilis (pink), and BF = biceps femoris (brown) in a transverse view and b linearly interpolated muscle volumes in 3D view

Fig

a

Manual

muscle

segmentation

of

ST

semitendinosus

yellow

RF

rectus

femoris

red

CS

cranial

sartorius

light

blue

AD

adductor

magnus

blue

GR

gracilis

pink

and

BF

biceps

femoris

brown

in

a

transverse

view

and

b

linearly

interpolated

muscle

volumes

in

view


Figure 1: Coronal and axial computed tomography views showing the base of acromion fracture.

Figure

Coronal

and

axial

computed

tomography

views

showing

the

base

of

acromion

fracture


Fig. 3 Repeat MRI assessment 2 days later confirmed the cord signal abnormality on standard T2 imaging (a) and showed concomitant apparent restriction on HASTE diffusion weighted imaging (DWI) (b) supporting a suspected acute ischaemic insult

Fig

Repeat

MRI

assessment

days

later

confirmed

the

cord

signal

abnormality

on

standard

imaging

a

and

showed

concomitant

apparent

restriction

on

HASTE

diffusion

weighted

imaging

DWI

b

supporting

a

suspected

acute

ischaemic

insult


Figure 1. (a) Pedigree (Numbers indicate number of siblings). (b) Homozygous missense mutation (C1085T (R335W) in exon 11 of the ITK gene. Chest X-Rays and thorax CT sections of Patient 1(c, d) and Patient 2 (e, f).

Figure

a

Pedigree

Numbers

indicate

number

of

siblings

b

Homozygous

missense

mutation

T

in

exon

of

the

ITK

gene

Chest

X

Rays

and

thorax

CT

sections

of

Patient

d

and

Patient

e

f


Figure 9. Sagittal sections showing projections of preganglionic neurons from transplants of older donor (stages 18-19) spinal cords into the sympathetic trunk of younger hosts (stages 13-14). At stage 27 of the host (A), donor Tl preganglionics are just entering into the sympathetic trunk of the host, and by stage 28 (B), they project 3 segments rostrally, whereas donor T4 preganglionics (arrow) are just beginning to enter into the sympathetic trunk. Scale bar, 0.4 mm.

Figure

Sagittal

sections

showing

projections

of

preganglionic

neurons

from

transplants

of

older

donor

stages

spinal

cords

into

the

sympathetic

trunk

of

younger

hosts

stages

At

stage

of

the

host

A

donor

Tl

preganglionics

are

just

entering

into

the

sympathetic

trunk

of

the

host

and

by

stage

B

they

project

segments

rostrally

whereas

donor

preganglionics

arrow

are

just

beginning

to

enter

into

the

sympathetic

trunk

Scale

bar

mm


Figure 1. Mammography and T2-weighted coronal images. (A) Mammography showing a single, ill-defined, non-calcified mass in the left breast. (B and C) T2-weighted coronal images showing a single, ill-defined, inhomogeneous, hyperintense mass.

Figure

Mammography

and

coronal

images

A

Mammography

showing

a

single

ill

defined

non

calcified

mass

in

the

left

breast

B

and

C

coronal

images

showing

a

single

ill

defined

inhomogeneous

hyperintense

mass


Fig. 3 The tumor cells are diffusely positive for p63 (a) and there is strong nuclear positivity for EBV in the nuclei of the tumor cells (b; EBER-ISH)

Fig

The

tumor

cells

are

diffusely

positive

for

a

and

there

is

strong

nuclear

positivity

for

EBV

in

the

nuclei

of

the

tumor

cells

b

EBER

ISH


Fig. 2 Corneal confocal microscopy imaging in an 8-year old child with Schnyder corneal dystrophy. Superficial epithelial cells with small round hyperreflective deposits (arrows) in the left eye (a). Normal appearance of the basal epithelial cell layer (b), and subepithelial nerve plexus in the right eye (c). Hyper-reflective deposits within and around keratocytes (arrows) (d) and needle-shaped crystals in anterior stroma of the left eye (e). Hyper-reflective deposits in mid-stroma in the left eye (f), but with unaffected posterior stroma (g) and endothelium in the left eye (h)

Fig

Corneal

confocal

microscopy

imaging

in

an

old

child

with

Schnyder

corneal

dystrophy

Superficial

epithelial

cells

with

small

round

hyperreflective

deposits

arrows

in

the

left

eye

a

Normal

appearance

of

the

basal

epithelial

cell

layer

b

and

subepithelial

nerve

plexus

in

the

right

eye

c

Hyper

reflective

deposits

within

and

around

keratocytes

arrows

d

and

needle

shaped

crystals

in

anterior

stroma

of

the

left

eye

e

Hyper

reflective

deposits

in

mid

stroma

in

the

left

eye

f

but

with

unaffected

posterior

stroma

g

and

endothelium

in

the

left

eye

h


Fig. 2. Nuclear import of the C domain of E2 in in vitro assays in digitoninpermeabilized cells. Digitonin-permeabilized HeLa cells were incubated with either GST-cE2 (A and B), or GST-NLS 16L1 (C and D), or GST, as a negative control (E and F) in the presence of either only transport buffer (A, C and E) or HeLa cytosol (B, D and F). Nuclear localization of the GST fusion proteins was detected by immunofluorescence microscopy with an anti-GST antibody. Note the nuclear import of GST-cE2 and GST-NLS 16L1 in panels B and D.

Fig

Nuclear

import

of

the

C

domain

of

in

in

vitro

assays

in

digitoninpermeabilized

cells

Digitonin

permeabilized

HeLa

cells

were

incubated

with

either

GST

A

and

B

or

GST

NLS

C

and

D

or

GST

as

a

negative

control

E

and

F

in

the

presence

of

either

only

transport

buffer

A

C

and

E

or

HeLa

cytosol

B

D

and

F

Nuclear

localization

of

the

GST

fusion

proteins

was

detected

by

immunofluorescence

microscopy

with

an

anti

GST

antibody

Note

the

nuclear

import

of

GST

and

GST

NLS

in

panels

B

and

D.


Fig. 3. (A–B) Axial T1W MR Images shows corresponding hypointense lesion (star) in the pancreas. Lesion appears heterogeneous on T2W images and demonstrates intermediate signal intensity; (C) Axial post contrast fat suppressed T1W image shows mild enhancement; (D) Extensive mesenteric lymphadenopathy surrounding SMA (arrows).

Fig

A

B

Axial

MR

Images

shows

corresponding

hypointense

lesion

star

in

the

pancreas

Lesion

appears

heterogeneous

on

images

and

demonstrates

intermediate

signal

intensity

C

Axial

post

contrast

fat

suppressed

image

shows

mild

enhancement

D

Extensive

mesenteric

lymphadenopathy

surrounding

SMA

arrows


Figure 3: (a)-(c) Head CT images showing acute epidural hematoma at the left occipital region prior to and after surgery. (a) Head CT images prior to surgery; bleeding volume was approximately 13 mL. (b) Head CT images 3 days after surgery; hematoma volume was obviously reduced. Arrows indicate the site of hematoma and drainage tube. (c) Head CT images 5 days after surgery; hematoma was almost cleared, and the drainage tube was pulled off.

Figure

a)-(c

Head

CT

images

showing

acute

epidural

hematoma

at

the

left

occipital

region

prior

to

and

after

surgery

a

Head

CT

images

prior

to

surgery

bleeding

volume

was

approximately

mL.

b

Head

CT

images

days

after

surgery

hematoma

volume

was

obviously

reduced

Arrows

indicate

the

site

of

hematoma

and

drainage

tube

c

Head

CT

images

days

after

surgery

hematoma

was

almost

cleared

and

the

drainage

tube

was

pulled

off


Fig. 5 Visualization of Xanthomonas oryzae pv. oryzae (Xoo) in rice plants. (A, B) Transverse leaf sections of rice infected with Xoo strain PXO99 expressing the green fluorescence of rice cultivar TP309 (susceptible) (A) and TP309-XA21 (resistant) (B). Images were observed with excitation from 450 to 490 nm and emitted light collected at 520 nm at 40¥ magnification using a Zeiss Axiophot fluorescence microscope, 12 days after inoculation. The bars in (A) and (B) represent 50 mm. (C) Scanning electron micrograph of Xoo cells in the xylem vessel of a rice leaf. (D) Close-up of Xoo-infected rice leaf. Bacterial cells fill the xylem vessels and ooze out at hydathodes, forming beads or strands of exudate on the leaf surface, a characteristic sign of the disease. Photographs in (A) and (B) courtesy of S. W. Han (reprinted from BMC Microbiol. 2008; 8: 164). Photograph in (C) courtesy of J. Leach (reprinted from Mol. Plant Pathol. 2006; 7(5): 303-324). Photograph in (D) courtesy of the Bureau of Rice Research and Development, Thailand (http://www.brrd.in.th).

Fig

Visualization

of

Xanthomonas

oryzae

pv

oryzae

Xoo

in

rice

plants

A

B

Transverse

leaf

sections

of

rice

infected

with

Xoo

strain

expressing

the

green

fluorescence

of

rice

cultivar

susceptible

A

and

resistant

B

Images

were

observed

with

excitation

from

to

nm

and

emitted

light

collected

at

nm

at

magnification

using

a

Zeiss

Axiophot

fluorescence

microscope

days

after

inoculation

The

bars

in

A

and

B

represent

mm

C

Scanning

electron

micrograph

of

Xoo

cells

in

the

xylem

vessel

of

a

rice

leaf

D

Close

up

of

Xoo

infected

rice

leaf

Bacterial

cells

fill

the

xylem

vessels

and

ooze

out

at

hydathodes

forming

beads

or

strands

of

exudate

on

the

leaf

surface

a

characteristic

sign

of

the

disease

Photographs

in

A

and

B

courtesy

of

S.

W.

Han

reprinted

from

BMC

Microbiol

Photograph

in

C

courtesy

of

J.

Leach

reprinted

from

Mol

Plant

Pathol

Photograph

in

D

courtesy

of

the

Bureau

of

Rice

Research

and

Development

Thailand


Figure 1. Sagittal and frontal T1 MRI before (A-1 and A-2), and after treatment with Cabergoline (B-1 and B-2). notes: MRI of the brain and pituitary gland showed enormous invasive tumor mass lesion is mainly solid with two cystic components at sellar, infra-sellar, and supra-sellar area measures 6.5 × 5.7 × 5.9 cm in its anterior-posterior, transverse, craniocaudal dimensions respectively. The mass displaced the optic chiasm superiorly. Anterior portion shows retrochiasmatic component which is lobulated and shows a small to medium size lobule extending posteriorly to the left Cp angle (compressing the the left trigeminal nerve), with another small lobule extending posteriorly to the left orbit through the superior orbit fissure. The two cystic components are noted at the hypothalmic and third ventricle with fluid level (evidence of intra-lesional hemorrhage of the posterior extension of this mass along the left tentorial leaflet and adjacent left lateral border of the brainstem), likely representing pituitary apoplexy.

Figure

Sagittal

and

frontal

MRI

before

and

and

after

treatment

with

Cabergoline

and

notes

MRI

of

the

brain

and

pituitary

gland

showed

enormous

invasive

tumor

mass

lesion

is

mainly

solid

with

two

cystic

components

at

sellar

infra

sellar

and

supra

sellar

area

measures

cm

in

its

anterior

posterior

transverse

craniocaudal

dimensions

respectively

The

mass

displaced

the

optic

chiasm

superiorly

Anterior

portion

shows

retrochiasmatic

component

which

is

lobulated

and

shows

a

small

to

medium

size

lobule

extending

posteriorly

to

the

left

Cp

angle

compressing

the

the

left

trigeminal

nerve

with

another

small

lobule

extending

posteriorly

to

the

left

orbit

through

the

superior

orbit

fissure

The

two

cystic

components

are

noted

at

the

hypothalmic

and

third

ventricle

with

fluid

level

evidence

of

intra

lesional

hemorrhage

of

the

posterior

extension

of

this

mass

along

the

left

tentorial

leaflet

and

adjacent

left

lateral

border

of

the

brainstem

likely

representing

pituitary

apoplexy


Figure 2 - Preoperative transesophageal echocardiography images. (Midesophageal four chamber view). (LA = left atrium; LV = left ventricle; RA = right atrium; RV = right ventricle; IVS = interventricular septum) A) Systolic anterior motion: during systole (note the white arrow in the ECG trace) the anterior mitral leaflet can be seen kinked at the mid portion, bended into the left ventricular outflow tract (yellow arrow), causing left ventricular outflow tract obstruction. There is also loss of mitral leaflets coaptation. B) Through the resultant interleaflet gap a jet of severe mitral regurgitation is evidenced by color Doppler. Also note the intense subaortic aliasing due to the greatly increased velocity across the left ventricular outflow tract.

Figure

Preoperative

transesophageal

echocardiography

images

Midesophageal

four

chamber

view

LA

left

atrium

LV

left

ventricle

RA

right

atrium

RV

right

ventricle

IVS

interventricular

septum

A

Systolic

anterior

motion

during

systole

note

the

white

arrow

in

the

ECG

trace

the

anterior

mitral

leaflet

can

be

seen

kinked

at

the

mid

portion

bended

into

the

left

ventricular

outflow

tract

yellow

arrow

causing

left

ventricular

outflow

tract

obstruction

There

is

also

loss

of

mitral

leaflets

coaptation

B

Through

the

resultant

interleaflet

gap

a

jet

of

severe

mitral

regurgitation

is

evidenced

by

color

Doppler

Also

note

the

intense

subaortic

aliasing

due

to

the

greatly

increased

velocity

across

the

left

ventricular

outflow

tract


Fig. 3 – (A) MRI evidences triangular fibrocartilage lesion; (B) edema on the ulna head; and (C) semilunar edema.

Fig

A

MRI

evidences

triangular

fibrocartilage

lesion

B

edema

on

the

ulna

head

and

C

semilunar

edema


Figure 1 T1-weighted MR images after gadolinium contrast administration. (a) On sagittal and (b) axial views, the mass exhibited marked ringlike enhancement and a regular margin. Axial imaging showed the cervical spinal cord to be displaced posterolaterally to the right by the tumour

Figure

MR

images

after

gadolinium

contrast

administration

a

On

sagittal

and

b

axial

views

the

mass

exhibited

marked

ringlike

enhancement

and

a

regular

margin

Axial

imaging

showed

the

cervical

spinal

cord

to

be

displaced

posterolaterally

to

the

right

by

the

tumour


Figure 1 MRI perfusion scan at baseline and follow-up in one patient treated with VEGF-A 165 gene transfer followed by G-CSF. The recordings were performed 20 s after contrast infusion, demonstrating poor perfusion with no contrast enhancement in the lateral wall (black arrows), moderate perfusion with attenuated enhancement (white arrows) in the inferior wall, and normal perfusion in the anterior wall (transparent arrows).

Figure

MRI

perfusion

scan

at

baseline

and

follow

up

in

one

patient

treated

with

VEGF

A

gene

transfer

followed

by

G

CSF

The

recordings

were

performed

s

after

contrast

infusion

demonstrating

poor

perfusion

with

no

contrast

enhancement

in

the

lateral

wall

black

arrows

moderate

perfusion

with

attenuated

enhancement

white

arrows

in

the

inferior

wall

and

normal

perfusion

in

the

anterior

wall

transparent

arrows


Figure 4. Cell morphology from one Ct and two B-ALL BM samples. Microscopic evaluation of three BM samples, as examples: (A) Ct, (B) B-ALL (Pre-pre B), (C) B-ALL (Pre-B) (scale bar: 30 lm) (Olympus CK2, magnification 100·).

Figure

Cell

morphology

from

one

Ct

and

two

B

ALL

BM

samples

Microscopic

evaluation

of

three

BM

samples

as

examples

A

Ct

B

B

ALL

Pre

pre

B

C

B

ALL

Pre

B

scale

bar

lm

Olympus

magnification


FIG. 8. Representative injections of Feridex-labeled MSCs into the myocardium. a: Still frames depicting the infarcted myocardium highlighted by MDE imaging and indicated by arrows. b: The distal tip of the catheter is apposed against the infarct in the mid-apical septum under real-time MR guidance. c: A 30-mM Gd-DTPA injection is carried out and visualized as a hyperintense lesion. d: Feridex-labeled MSCs (7 106) are injected at the same location. e: The catheter was then repositioned below the previous injection site, and 30 mM Gd-DTPA were injected. f: Feridex-labeled MSCs (3 106 labeled, and 4 106 unlabeled) are injected at the same location, and both injections are visualized (the Gd-DTPA injection is bright, and the hypointense Feridex-labeled MSC injection is dark). The lower concentration of labeled MSCs can be appreciated as a less hypointense lesion in the more apical injection. All of the images were acquired with the use of a real-time SSFP sequence (TR 3.4 ms, TE 1.2 ms, FA 45° (90° for c and e), BW 125, image matrix 128 128, NEX 0.5) and the i-Drive interface to guide the procedure.

FIG

Representative

injections

of

Feridex

labeled

MSCs

into

the

myocardium

a

Still

frames

depicting

the

infarcted

myocardium

highlighted

by

MDE

imaging

and

indicated

by

arrows

b

The

distal

tip

of

the

catheter

is

apposed

against

the

infarct

in

the

mid

apical

septum

under

real

time

MR

guidance

c

A

Gd

DTPA

injection

is

carried

out

and

visualized

as

a

hyperintense

lesion

d

Feridex

labeled

MSCs

are

injected

at

the

same

location

e

The

catheter

was

then

repositioned

below

the

previous

injection

site

and

mM

Gd

DTPA

were

injected

f

Feridex

labeled

MSCs

labeled

and

unlabeled

are

injected

at

the

same

location

and

both

injections

are

visualized

the

Gd

DTPA

injection

is

bright

and

the

hypointense

Feridex

labeled

MSC

injection

is

dark

The

lower

concentration

of

labeled

MSCs

can

be

appreciated

as

a

less

hypointense

lesion

in

the

more

apical

injection

All

of

the

images

were

acquired

with

the

use

of

a

real

time

SSFP

sequence

TR

ms

TE

ms

FA

for

c

and

e

BW

image

matrix

NEX

and

the

i

Drive

interface

to

guide

the

procedure


Figure 3. Cardiac magnetic resonance imaging (MRI) in patients with autosomal dominant polycystic kidney disease (ADPKD) and hypertrophic obstructive cardiomyopathy (HOCM). (a) A 63-year-old female patient with ADPKD had cardiac MRI findings consistent with asymmetric left ventricular hypertrophy, measuring 21 mm in the basal anterior septum (marked with an asterisk). (b) A 58-year-old male patient with ADPKD had cardiac MRI, which revealed the sigmoid morphologic subtype of hypertrophic cardiomyopathy and maximal end-diastolic myocardial thickness of 19 mm at the basal anterior septum (marked with an asterisk).

Figure

Cardiac

magnetic

resonance

imaging

MRI

in

patients

with

autosomal

dominant

polycystic

kidney

disease

ADPKD

and

hypertrophic

obstructive

cardiomyopathy

HOCM

a

A

old

female

patient

with

ADPKD

had

cardiac

MRI

findings

consistent

with

asymmetric

left

ventricular

hypertrophy

measuring

mm

in

the

basal

anterior

septum

marked

with

an

asterisk

b

A

old

male

patient

with

ADPKD

had

cardiac

MRI

which

revealed

the

sigmoid

morphologic

subtype

of

hypertrophic

cardiomyopathy

and

maximal

end

diastolic

myocardial

thickness

of

mm

at

the

basal

anterior

septum

marked

with

an

asterisk


Figure 1. High-resolution magnetic resonance images of the hippocampus. A, A high-resolution (0.4 ϫ 0.5-mm inplane), T2-weighted magnetic resonance image of the brain shows a coronal section through the hippocampus. The zoomed-in image shows a view of the subfields (B) with the tracings in color superimposed (C). CA indicates cornu ammonis; DG, dentate gyrus; ERC, entorhinal cortex; and S, subiculum.

Figure

High

resolution

magnetic

resonance

images

of

the

hippocampus

A

A

high

resolution

ϫ

inplane

magnetic

resonance

image

of

the

brain

shows

a

coronal

section

through

the

hippocampus

The

zoomed

in

image

shows

a

view

of

the

subfields

B

with

the

tracings

in

color

superimposed

C

CA

indicates

cornu

ammonis

DG

dentate

gyrus

ERC

entorhinal

cortex

and

S

subiculum


Figure 2. (A) T1-weighted gadolinium-enhanced magnetic resonance imaging reveals a focal-enhancing mass in hepatic segment 7 (arrow). This mass demonstrated venous phase-contrast washout, meeting the guidelines for HCC. After discussion at multidiscipline tumor board, this nonoperative candidate underwent cTACE. (B) A noncontrast computed tomography scan performed immediately after cTACE revealed focal uptake of lipiodol within the targeted tumor (double arrows). There is some nontarget lipiodol uptake in the noncancerous hepatic parenchyma (arrowhead) adjacent to the tumor.

Figure

A

gadolinium

enhanced

magnetic

resonance

imaging

reveals

a

focal

enhancing

mass

in

hepatic

segment

arrow

This

mass

demonstrated

venous

phase

contrast

washout

meeting

the

guidelines

for

HCC

After

discussion

at

multidiscipline

tumor

board

this

nonoperative

candidate

underwent

cTACE

B

A

noncontrast

computed

tomography

scan

performed

immediately

after

cTACE

revealed

focal

uptake

of

lipiodol

within

the

targeted

tumor

double

arrows

There

is

some

nontarget

lipiodol

uptake

in

the

noncancerous

hepatic

parenchyma

arrowhead

adjacent

to

the

tumor


Figure 3. Transverse sections of caput epididymidis of mice following SAL treatment (a) control; (b) 1mg/kg; (c) 1mg/kg; (d) 3mg/kg; (e) 3mg/kg (f) 5mg/kg & (g) 5mg/ kg. Note: Figures c, e & g are from the recovery groups. doi: 10.1371/journal.pone.0069086.g003

Figure

Transverse

sections

of

caput

epididymidis

of

mice

following

SAL

treatment

a

control

b

kg

c

kg

d

kg

e

kg

f

kg

g

kg

Note

Figures

c

e

g

are

from

the

recovery

groups

doi


Figure 1. (a) Injury of the orbit from penetration by a pencil. Clinical features include proptosis, chemosis, and loss of vision due to raised intraorbital pressure. (b) CT scan identifies gas within the orbit, which together with the soft tissue swelling, accounts for the rise in orbital pressure. b a

Figure

a

Injury

of

the

orbit

from

penetration

by

a

pencil

Clinical

features

include

proptosis

chemosis

and

loss

of

vision

due

to

raised

intraorbital

pressure

b

CT

scan

identifies

gas

within

the

orbit

which

together

with

the

soft

tissue

swelling

accounts

for

the

rise

in

orbital

pressure

b

a


Figure 3 Laser disruptions of a cerebral capillary (1) and a branch vessel (2) on mouse cortex. Upper panel: maximum intensity projection (MIP) images of microvasculature imaging (optical coherence angiography) at baseline (a), after laser disruption of a f9 mm capillary (b) and of a f35.8 mm arteriole (c). Red/blue arrows: flow directions of arterioles/venules, dots: vessel junctures. Lower panel: MIP images of cerebral blood flow (CBF; microvascular imaging by optical Doppler tomography) at baseline (d) and after laser disruptions (e, f). Angiography detects no difference except reduced vasculature in the immediate areas (dashed green circles in panels b and c) around laser disruption (green dots); whereas quantitative CBF reveals vastly expanded vasodilatation almost over the entire field after laser disruption of a capillary (dashed outer green circle in panel e) and the quenching of local CBF networks over a much larger area (dashed green circle in panel e). Quantitative comparisons among 20 capillaries indicate that CBF increased significantly from 0.105±0.049 mm s À1 at baseline to 0.211±0.048 mm s À1 at 30 min after laser disruption (g and h; P < 0.001). Image size: 1 Â 1.2 Â 1 mm 3 . Laser radiation: 532 nm per 60 mW, Bf3 mm focal spot; 2 and 6 min exposures for capillary (1) and arteriole (2), respectively.

Figure

Laser

disruptions

of

a

cerebral

capillary

and

a

branch

vessel

on

mouse

cortex

Upper

panel

maximum

intensity

projection

MIP

images

of

microvasculature

imaging

optical

coherence

angiography

at

baseline

a

after

laser

disruption

of

a

mm

capillary

b

and

of

a

mm

arteriole

c

Red

blue

arrows

flow

directions

of

arterioles

venules

dots

vessel

junctures

Lower

panel

MIP

images

of

cerebral

blood

flow

CBF

microvascular

imaging

by

optical

Doppler

tomography

at

baseline

d

and

after

laser

disruptions

e

f

Angiography

detects

no

difference

except

reduced

vasculature

in

the

immediate

areas

dashed

green

circles

in

panels

b

and

c

around

laser

disruption

green

dots

whereas

quantitative

CBF

reveals

vastly

expanded

vasodilatation

almost

over

the

entire

field

after

laser

disruption

of

a

capillary

dashed

outer

green

circle

in

panel

e

and

the

quenching

of

local

CBF

networks

over

a

much

larger

area

dashed

green

circle

in

panel

e

Quantitative

comparisons

among

capillaries

indicate

that

CBF

increased

significantly

from

mm

s

À1

at

baseline

to

mm

s

À1

at

min

after

laser

disruption

g

and

h

P

Image

size

Â

Â

mm

Laser

radiation

nm

per

mW

mm

focal

spot

and

min

exposures

for

capillary

and

arteriole

respectively


Figure 8. SEM images of PDMS/ODA-coated PET fabric (a) after 1 st plasma treatment, (b) after 1 st automatically healed at room temperature for 12 h, (c) after 8 times etching-healing cycles at room temperature, (d) after 7 times etching-heating cycles.

Figure

SEM

images

of

PDMS

ODA

coated

PET

fabric

a

after

st

plasma

treatment

b

after

st

automatically

healed

at

room

temperature

for

h

c

after

times

etching

healing

cycles

at

room

temperature

d

after

times

etching

heating

cycles


FIGURE 1 Imaging and histological correlation in lung adenocarcinoma classification. a) Computed tomography (CT) scan demonstrating a ground-glass nodule that on resection represents adenocarcinoma in situ. b) The preserved alveolar architecture is seen at low magnification in this adenocarcinoma in situ. Scale bar=3 mm. c) CT scan demonstrating a solid area surrounded by a rim of ground-glass attenutation. d) On resection, this was an acinar predominant adenocarcinoma with gland formation seen on the histology image.

FIGURE

Imaging

and

histological

correlation

in

lung

adenocarcinoma

classification

a

Computed

tomography

CT

scan

demonstrating

a

ground

glass

nodule

that

on

resection

represents

adenocarcinoma

in

situ

b

The

preserved

alveolar

architecture

is

seen

at

low

magnification

in

this

adenocarcinoma

in

situ

Scale

mm

c

CT

scan

demonstrating

a

solid

area

surrounded

by

a

rim

of

ground

glass

attenutation

d

On

resection

this

was

an

acinar

predominant

adenocarcinoma

with

gland

formation

seen

on

the

histology

image


Figure 3. 66-year-old male with dedifferentiated liposarcoma of the right breast. Targeted right breast ultrasound was performed in the areas of the palpable and the mammographic abnormalities. A. Transverse and sagittal images of the right breast, 11-12 o’clock region, show a 9.2-cm isoechoic mass with a 4-cm cystic component. B. Transverse and sagittal images of the right axilla show a 3.9-cm hypoechoic mass with irregular margins, suspicious for malignancy.

Figure

old

male

with

dedifferentiated

liposarcoma

of

the

right

breast

Targeted

right

breast

ultrasound

was

performed

in

the

areas

of

the

palpable

and

the

mammographic

abnormalities

A.

Transverse

and

sagittal

images

of

the

right

breast

o’clock

region

show

a

isoechoic

mass

with

a

cystic

component

B.

Transverse

and

sagittal

images

of

the

right

axilla

show

a

hypoechoic

mass

with

irregular

margins

suspicious

for

malignancy


Fig. 5. Different emphases in the investigation of neural mechanisms for associative prediction vs. perceptual expertise. A: Medial view of the typical contextual association network (e.g., Bar and Aminoff, 2003) and its overlap with the default network (e.g., Raichle et al., 2001). The context network activations are obtained from the contrast between strongly contextually associative objects (e.g., a tennis racket) and weakly contextually associative objects (e.g., a jacket). The default network regions are those that are more active during fixation rest than during task performance. MPC, medial parietal cortex. MTL, middle temporal lobe. MPFC, medial prefrontal cortex. B: An axial oblique slice through the right ‘fusiform face area’ (FFA, marked with a red circle), one of the local regions emphasized in several perceptual expertise studies (for subordinate-level expertise, e.g., Gauthier et al., 1999, 2000a,b; Wong et al., 2009b), for a car expert and a bird expert. The FFA was first defined by more robust activations for faces than objects. In Gauthier et al. (2000a), this area was found to be more activated for car experts when viewing cars compared to other objects, and for bird experts when viewing birds compared to other objects. Copyrights © by Elsevier Ltd. and Nature America Inc. respectively. Adapted with permission.

Fig

Different

emphases

in

the

investigation

of

neural

mechanisms

for

associative

prediction

vs.

perceptual

expertise

A

Medial

view

of

the

typical

contextual

association

network

e.g.

Bar

and

Aminoff

and

its

overlap

with

the

default

network

e.g.

Raichle

et

al

The

context

network

activations

are

obtained

from

the

contrast

between

strongly

contextually

associative

objects

e.g.

a

tennis

racket

and

weakly

contextually

associative

objects

e.g.

a

jacket

The

default

network

regions

are

those

that

are

more

active

during

fixation

rest

than

during

task

performance

MPC

medial

parietal

cortex

MTL

middle

temporal

lobe

MPFC

medial

prefrontal

cortex

B

An

axial

oblique

slice

through

the

right

fusiform

face

area

FFA

marked

with

a

red

circle

one

of

the

local

regions

emphasized

in

several

perceptual

expertise

studies

for

subordinate

level

expertise

e.g.

Gauthier

et

al

b

Wong

et

al

for

a

car

expert

and

a

bird

expert

The

FFA

was

first

defined

by

more

robust

activations

for

faces

than

objects

In

Gauthier

et

al

this

area

was

found

to

be

more

activated

for

car

experts

when

viewing

cars

compared

to

other

objects

and

for

bird

experts

when

viewing

birds

compared

to

other

objects

Copyrights

by

Elsevier

Ltd.

and

Nature

America

Inc.

respectively

Adapted

with

permission


Figure 4. CT. a. The maximum diameter of the tumor was 45 mm in 1997. b: In 2001, the maximum diameter was de creased to 31 mm with cystic change in the periphery of the tumor (arrow). c: The maximum diameter had become 15 mm by 2007.

Figure

CT

a.

The

maximum

diameter

of

the

tumor

was

mm

in

b

In

the

maximum

diameter

was

de

creased

to

mm

with

cystic

change

in

the

periphery

of

the

tumor

arrow

c

The

maximum

diameter

had

become

mm

by


Figure 2. a, b. A 77-year-old female patient with multiple metastases from lung cancer. Sagittal T2 Dixon water-only image (a) provides uniform fat suppression and shows clear extent of metastases at L3, L5, S1, S2, and S3. SPAIR image (b) fails to show the full extent of metastases due to incomplete fat suppression at coccyx region.

Figure

a

b.

A

old

female

patient

with

multiple

metastases

from

lung

cancer

Sagittal

Dixon

water

only

image

a

provides

uniform

fat

suppression

and

shows

clear

extent

of

metastases

at

and

SPAIR

image

b

fails

to

show

the

full

extent

of

metastases

due

to

incomplete

fat

suppression

at

coccyx

region


FIG. 2. Adult rat thymocytes. Transferase was stained as in Fig. 1. (X775.) (A) Small thymocytes displaying combined cytoplasmic (peripheral "halo") and nuclear (central stippling) patterns of fluorescence. (B and C) Large thymocytes with nuclear pattern of fluorescence similar to that in Fig. 1 B and C. Note absence of cytoplasmic and nucleolar fluorescence. medium-sized, lymphocyte-like bone marrow cells showed a coarsely clumped pattern of intranuclear fluorescence that resembled the aggregated pattern of heterochromatin seen in Wright's stained preparations. Some large, blast-like bone marrow cells exhibited a more diffuse, finely granular pattern of intranuclear fluorescence that resembled the dispersed chromatin pattern seen in these cells. Thy-1.i Antigen on Transferase-Positive Bone Marrow Cells. Adult rat bone marrow cells were tested for the simultaneous presence of Thy-1.1 and transferase antigens by dual immunofluorescence. Anti-Thy-i.i staining (rhodamine-positive) was restricted to the cell surface; anti-transferase staining (fluorescein-positive) was restricted to the cell nucleus. Approximately 30% of nucleated bone marrow cells were found to be Thy-1.1 positive, as reported elsewhere (18). Of these, approximately 10% were transferase-positive (i.e., showed dual fluorescence). Conversely, essentially all transferase-positive bone marrow cells were Thy-i. I positive. Intranuclear Distribution of Terminal Transferase in Thymocytes. As we and others have reported (2, 14), terminal transferase appears to occupy a predominantly cytoplasmic position in cortical thymocytes from adult rats. The use of a Cytospin centrifuge to prepare cell smears and the use of affinity-column-purified anti-transferase for immunofluorescence permitted more precise resolution of the intracellular distribution of this enzyme in the present experiments. In the flattened preparation from the cytocentrifuge, many small thymocytes had detectable nuclear fluorescence as well as cytoplasmic fluorescence (Fig. 2A). Some large, immature thymocytes had the nuclear pattern of fluorescence reminiscent

FIG

Adult

rat

thymocytes

Transferase

was

stained

as

in

Fig

A

Small

thymocytes

displaying

combined

cytoplasmic

peripheral

halo

and

nuclear

central

stippling

patterns

of

fluorescence

B

and

C

Large

thymocytes

with

nuclear

pattern

of

fluorescence

similar

to

that

in

Fig

B

and

C.

Note

absence

of

cytoplasmic

and

nucleolar

fluorescence

medium

sized

lymphocyte

like

bone

marrow

cells

showed

a

coarsely

clumped

pattern

of

intranuclear

fluorescence

that

resembled

the

aggregated

pattern

of

heterochromatin

seen

in

Wright

's

stained

preparations

Some

large

blast

like

bone

marrow

cells

exhibited

a

more

diffuse

finely

granular

pattern

of

intranuclear

fluorescence

that

resembled

the

dispersed

chromatin

pattern

seen

in

these

cells

Antigen

on

Transferase

Positive

Bone

Marrow

Cells

Adult

rat

bone

marrow

cells

were

tested

for

the

simultaneous

presence

of

and

transferase

antigens

by

dual

immunofluorescence

Anti

Thy

i.i

staining

rhodamine

positive

was

restricted

to

the

cell

surface

anti

transferase

staining

fluorescein

positive

was

restricted

to

the

cell

nucleus

Approximately

of

nucleated

bone

marrow

cells

were

found

to

be

positive

as

reported

elsewhere

Of

these

approximately

were

transferase

positive

i.e.

showed

dual

fluorescence

Conversely

essentially

all

transferase

positive

bone

marrow

cells

were

Thy

i

I

positive

Intranuclear

Distribution

of

Terminal

Transferase

in

Thymocytes

As

we

and

others

have

reported

terminal

transferase

appears

to

occupy

a

predominantly

cytoplasmic

position

in

cortical

thymocytes

from

adult

rats

The

use

of

a

Cytospin

centrifuge

to

prepare

cell

smears

and

the

use

of

affinity

column

purified

anti

transferase

for

immunofluorescence

permitted

more

precise

resolution

of

the

intracellular

distribution

of

this

enzyme

in

the

present

experiments

In

the

flattened

preparation

from

the

cytocentrifuge

many

small

thymocytes

had

detectable

nuclear

fluorescence

as

well

as

cytoplasmic

fluorescence

Fig

Some

large

immature

thymocytes

had

the

nuclear

pattern

of

fluorescence

reminiscent


Figure 1: Abdominal MRI T2 FFE (fast field echo) sequences show hypointense liver, spleen, pancreas and bone signal due to abnormal iron deposition. (A, B) patients with intense transfusion regimen history; (C) patient with only 5 transfusion before MRI quantification of iron concentration; (D) patient treated with deferasirox: minor liver hyperintensity compared to spleen, pancreas and bone intensity.

Figure

Abdominal

MRI

FFE

fast

field

echo

sequences

show

hypointense

liver

spleen

pancreas

and

bone

signal

due

to

abnormal

iron

deposition

A

B

patients

with

intense

transfusion

regimen

history

C

patient

with

only

transfusion

before

MRI

quantification

of

iron

concentration

D

patient

treated

with

deferasirox

minor

liver

hyperintensity

compared

to

spleen

pancreas

and

bone

intensity


Figure 3. HIM-8 is a C2H2 Zinc-Finger Protein that Localizes to Distinct Nuclear Foci during Meiosis (A) Three-dimensional projection through a wild-type gonad stained with DAPI and antibodies against HIM-8. Subnuclear HIM-8 foci are present in all germline nuclei throughout the premeiotic, transition-zone, and pachytene region of the gonad. The transition-zone region outlined by the yellow box is magnified in (B). (B) Prior to meiotic entry, two HIM-8 foci (yellow) are observed in each nucleus. Examples of premeiotic nuclei in which two foci can be clearly observed are outlined in brown circles. Once nuclei have entered the transition zone, representing the leptotene/zygotene stages of meiosis, they usually reveal only a single HIM-8 focus or closely spaced pair of foci. The scale bar represents 5 mm. (C) Schematic representation of the HIM-8 protein. The diagram displays the location of two predicted zinc fingers as well as the sites of point mutations or deletions resulting from the four mutant alleles of him-8.

Figure

is

a

Zinc

Finger

Protein

that

Localizes

to

Distinct

Nuclear

Foci

during

Meiosis

A

Three

dimensional

projection

through

a

wild

type

gonad

stained

with

DAPI

and

antibodies

against

Subnuclear

foci

are

present

in

all

germline

nuclei

throughout

the

premeiotic

transition

zone

and

pachytene

region

of

the

gonad

The

transition

zone

region

outlined

by

the

yellow

box

is

magnified

in

B

B

Prior

to

meiotic

entry

two

foci

yellow

are

observed

in

each

nucleus

Examples

of

premeiotic

nuclei

in

which

two

foci

can

be

clearly

observed

are

outlined

in

brown

circles

Once

nuclei

have

entered

the

transition

zone

representing

the

leptotene

zygotene

stages

of

meiosis

they

usually

reveal

only

a

single

focus

or

closely

spaced

pair

of

foci

The

scale

bar

represents

mm

C

Schematic

representation

of

the

protein

The

diagram

displays

the

location

of

two

predicted

zinc

fingers

as

well

as

the

sites

of

point

mutations

or

deletions

resulting

from

the

four

mutant

alleles

of


Fig. 5. Case 2: This 42-year-old woman presented with sudden severe headache. (A) The preoperative axial computed tomography (CT) scan shows right-frontal-base hemorrhage. Note that the aneurysm is situated at the site of the hemorrhage. The anterior clinoid process (ACP) is an obstacle to the clipping of an aneurysm. (B) The 3-dimensional (3D) CT angiography shows the superolateral side of the paraclinoid internal carotid artery aneurysm. (C) The postoperative CT scan 3D reconstruction skull image shows that the entire ACP was removed and that the aneurysm was clipped with 2 15-mm curved clips.

Fig

Case

This

old

woman

presented

with

sudden

severe

headache

A

The

preoperative

axial

computed

tomography

CT

scan

shows

right

frontal

base

hemorrhage

Note

that

the

aneurysm

is

situated

at

the

site

of

the

hemorrhage

The

anterior

clinoid

process

ACP

is

an

obstacle

to

the

clipping

of

an

aneurysm

B

The

CT

angiography

shows

the

superolateral

side

of

the

paraclinoid

internal

carotid

artery

aneurysm

C

The

postoperative

CT

scan

reconstruction

skull

image

shows

that

the

entire

ACP

was

removed

and

that

the

aneurysm

was

clipped

with

curved

clips


Figure 3. MMP-targeted imaging of vascular remodeling in abdominal aortic aneurysm. Examples of fused 99m Tc-P805 microSPECT and CT images of matrix metalloproteinase activation in abdominal aortae of a control mouse ((top) row) and animals infused with angiotensin II to induce abdominal aortic aneurysm. A mouse infused with angiotensin II for 4 weeks that developed abdominal aortic aneurysm shows RP805 uptake in the aneurysm ((bottom) row), whereas there is no notable tracer uptake in the abdominal aortae of the control mouse (top row) and an angiotensin II-infused mouse that did not develop aneurysm ((middle) row). T: transvers, C: coronal, S: sagittal. Arrows point to abdominal aortae, identified by CT angiography. Published with permission of Wolters Kluwer Health from "Imaging vessel wall biology to predict outcome in abdominal aortic aneurysm", Golestani, R., et al. Circ. Cardiovasc. Imaging 2015, 8(1), e002471 [56].

Figure

MMP

targeted

imaging

of

vascular

remodeling

in

abdominal

aortic

aneurysm

Examples

of

fused

m

Tc

microSPECT

and

CT

images

of

matrix

metalloproteinase

activation

in

abdominal

aortae

of

a

control

mouse

top

row

and

animals

infused

with

angiotensin

II

to

induce

abdominal

aortic

aneurysm

A

mouse

infused

with

angiotensin

II

for

weeks

that

developed

abdominal

aortic

aneurysm

shows

uptake

in

the

aneurysm

bottom

row

whereas

there

is

no

notable

tracer

uptake

in

the

abdominal

aortae

of

the

control

mouse

top

row

and

an

angiotensin

II

infused

mouse

that

did

not

develop

aneurysm

middle

row

T

transvers

C

coronal

S

sagittal

Arrows

point

to

abdominal

aortae

identified

by

CT

angiography

Published

with

permission

of

Wolters

Kluwer

Health

from

Imaging

vessel

wall

biology

to

predict

outcome

in

abdominal

aortic

aneurysm

Golestani

R.

et

al

Circ

Cardiovasc

Imaging


Figure 1. A, T1-weighted coronal magnetic resonance imaging scans with fat saturation and gadolinium enhancement of the superior orbital fissure (lower arrow) and planum sphenoidalis (upper arrow) of a 65-year-old man (case 1). The right optic nerve sheath and orbital apex were enhanced (arrow) and were the site of the third transcranial biopsy (B). The swollen posterior optic canal dura showed polymorphonuclear leukocytes (hematoxylin-eosin, original magnification ×400 [C]), samples of which grew Pseudomonas aeruginosa on culture.

Figure

A

coronal

magnetic

resonance

imaging

scans

with

fat

saturation

and

gadolinium

enhancement

of

the

superior

orbital

fissure

lower

arrow

and

planum

sphenoidalis

upper

arrow

of

a

old

man

case

The

right

optic

nerve

sheath

and

orbital

apex

were

enhanced

arrow

and

were

the

site

of

the

third

transcranial

biopsy

B

The

swollen

posterior

optic

canal

dura

showed

polymorphonuclear

leukocytes

hematoxylin

eosin

original

magnification

C

samples

of

which

grew

Pseudomonas

aeruginosa

on

culture


Fig. 1. OCT images of neointima. (A) Lipidic change. (B) Calcific change. Arrows indicate lipid and calcification within neointima, respectively. OCT = optical coherence tomography.

Fig

OCT

images

of

neointima

A

Lipidic

change

B

Calcific

change

Arrows

indicate

lipid

and

calcification

within

neointima

respectively

OCT

optical

coherence

tomography


Fig. 6: a: A pre-contrast T1-weighted image of patient 11 in the sagittal plane. The triangular mass is visible just caudal to the upper canine (small arrows). The dorsal and caudal margins of the mass are indistinct (block arrow). Diagnosis: squamous cell carcinoma. b: Patient 11. Post-contrast T1-weighted image of the same slice does not improve dorsal and caudal delineation of the mass. Notice the normal, moderate homogenous contrast uptake by the nasal turbinates. c: Patient 11. A transverse T2-weighted image of the same tumour clearly shows that there is no extension of the mass into the nasal turbinates (arrows). The mass is hypointense to the nasal turbinates on T2-weighted images.

Fig

a

A

pre

contrast

image

of

patient

in

the

sagittal

plane

The

triangular

mass

is

visible

just

caudal

to

the

upper

canine

small

arrows

The

dorsal

and

caudal

margins

of

the

mass

are

indistinct

block

arrow

Diagnosis

squamous

cell

carcinoma

b

Patient

Post

contrast

image

of

the

same

slice

does

not

improve

dorsal

and

caudal

delineation

of

the

mass

Notice

the

normal

moderate

homogenous

contrast

uptake

by

the

nasal

turbinates

c

Patient

A

transverse

image

of

the

same

tumour

clearly

shows

that

there

is

no

extension

of

the

mass

into

the

nasal

turbinates

arrows

The

mass

is

hypointense

to

the

nasal

turbinates

on

images


Figure 1. The imaging findings of this patient. (A) Many quasi-circular high density nodes on both cerebral hemispheres can be seen using brain computed tomography (CT). (B) Brain magnetic resonance images (MRI) (plain and enhance scan) revealed multiple lesions in the brain. (C) Brain MRI showed the nodes were low density inside whereas high density outside. (D) Brain CT examined on October 18th 2016 showed that focal intracerebral hemorrhage was absorbed. CT = computed tomography, MRI = magnetic resonance images.

Figure

The

imaging

findings

of

this

patient

A

Many

quasi

circular

high

density

nodes

on

both

cerebral

hemispheres

can

be

seen

using

brain

computed

tomography

CT

B

Brain

magnetic

resonance

images

MRI

plain

and

enhance

scan

revealed

multiple

lesions

in

the

brain

C

Brain

MRI

showed

the

nodes

were

low

density

inside

whereas

high

density

outside

D

Brain

CT

examined

on

October

showed

that

focal

intracerebral

hemorrhage

was

absorbed

CT

computed

tomography

MRI

magnetic

resonance

images


Figure 1: CT scan of the abdomen. (a) Coronal and (b) axial images revealed a large intraperitoneal solid, cystic mass (red arrow) with intralesional calcification and fat, displacing the small bowel loops to the left side of the midline. (c) Sagittal and (d) axial images revealed a polypoidal intragastric extension of the mass lesion across the posterior wall of the stomach (white arrows).

Figure

CT

scan

of

the

abdomen

a

Coronal

and

b

axial

images

revealed

a

large

intraperitoneal

solid

cystic

mass

red

arrow

with

intralesional

calcification

and

fat

displacing

the

small

bowel

loops

to

the

left

side

of

the

midline

c

Sagittal

and

d

axial

images

revealed

a

polypoidal

intragastric

extension

of

the

mass

lesion

across

the

posterior

wall

of

the

stomach

white

arrows


Figure 1. (a) Preoperative radiograph showing a large periapical lesion with loss of lamina dura surrounding the mesial root of lower first molar; (b) Nonsurgical endodontic retreatment was carried out for involved molar but sign/symptoms did not resolve; (c) Pulp Vitality test revealed that the intact adjacent premolar was nonvital and nonsurgical endodontic treatment was carried out; (d, e) Six- and 12-month follow-up radiographs showing gradual bone healing; (f) Two-year follow-up radiograph reveals complete bone healing.

Figure

a

Preoperative

radiograph

showing

a

large

periapical

lesion

with

loss

of

lamina

dura

surrounding

the

mesial

root

of

lower

first

molar

b

Nonsurgical

endodontic

retreatment

was

carried

out

for

involved

molar

but

sign

symptoms

did

not

resolve

c

Pulp

Vitality

test

revealed

that

the

intact

adjacent

premolar

was

nonvital

and

nonsurgical

endodontic

treatment

was

carried

out

d

e

Six-

and

follow

up

radiographs

showing

gradual

bone

healing

f

Two

year

follow

up

radiograph

reveals

complete

bone

healing


Figure 1. Transverse chest CT images of 4 patients who were almost the same height and weight. Images were reconstructed with 30% ASIR. Images are (A) NI = 15, objective image noise 10.95; (B) NI = 20, objective image noise 18.28, (C) NI = 30, objective image noise 28.5, and (D) NI = 40, objective image noise 41.52. The visibility of the small structure (arrow) in D was around average. doi:10.1371/journal.pone.0092414.g001

Figure

Transverse

chest

CT

images

of

patients

who

were

almost

the

same

height

and

weight

Images

were

reconstructed

with

ASIR

Images

are

A

NI

objective

image

noise

B

NI

objective

image

noise

C

NI

objective

image

noise

and

D

NI

objective

image

noise

The

visibility

of

the

small

structure

arrow

in

D

was

around

average


Fig. 1. Ultrasound appearance of normal healing of a grade II muscle injury (partial tear) at the rectus femoris muscle near the superficial aponeurosis. There is a hypoechoic area filled with fluid (calipers) 3 days after injury (A). Three weeks later, the gap has filled with mildly hypoechoic tissue (asterisk) (B)

Fig

Ultrasound

appearance

of

normal

healing

of

a

grade

II

muscle

injury

partial

tear

at

the

rectus

femoris

muscle

near

the

superficial

aponeurosis

There

is

a

hypoechoic

area

filled

with

fluid

calipers

days

after

injury

A

Three

weeks

later

the

gap

has

filled

with

mildly

hypoechoic

tissue

asterisk

B


Figure 1: A 31-year-old man with 22q11.2 deletion syndrome who presented for evaluation of vascular anomalies. (a) Contrast-enhanced computed tomography of the thorax axial image demonstrates the main pulmonary trunk (P) giving rise to the right pulmonary artery (R) with the absence of the left pulmonary artery and hypertrophied collateral left bronchial artery (black arrow). (b) Computed tomography axial image demonstrates a right-sided aortic arch (A) and hypertrophied collateral left intercostal arteries (white arrow heads) and bronchial artery (white arrow) supplying the left lung. (c) Computed tomography axial image in lung window shows reticular opacities penetrating the peripheral left lung parenchyma representing intercostal artery collaterals (arrows). The left lung is slightly smaller compared to the right. (d) Computed tomography axial image shows no discernible thymic tissue in the anterior mediastinum. d c

Figure

A

old

man

with

deletion

syndrome

who

presented

for

evaluation

of

vascular

anomalies

a

Contrast

enhanced

computed

tomography

of

the

thorax

axial

image

demonstrates

the

main

pulmonary

trunk

P

giving

rise

to

the

right

pulmonary

artery

R

with

the

absence

of

the

left

pulmonary

artery

and

hypertrophied

collateral

left

bronchial

artery

black

arrow

b

Computed

tomography

axial

image

demonstrates

a

right

sided

aortic

arch

A

and

hypertrophied

collateral

left

intercostal

arteries

white

arrow

heads

and

bronchial

artery

white

arrow

supplying

the

left

lung

c

Computed

tomography

axial

image

in

lung

window

shows

reticular

opacities

penetrating

the

peripheral

left

lung

parenchyma

representing

intercostal

artery

collaterals

arrows

The

left

lung

is

slightly

smaller

compared

to

the

right

d

Computed

tomography

axial

image

shows

no

discernible

thymic

tissue

in

the

anterior

mediastinum

d

c


Figure 1: (A and B) Transthoracic echocardiography and transoesophageal echocardiography showing the mass over the pulmonary valve (PV) (arrow). (C) Cardiac magnetic resonance (CMR) (Discovery 450, General Electric Healthcare, 1.5 T Unit, Milwaukee, WI, USA) scan images showing a spherical mass (arrow), 8×7.5 mm in dimension, attached to the anterior leaflet of the PV. The papillary fibroelastoma (PFE) appears hypointense compared with heart chambers in this steady-state free precession sequence. (D) CMR highlighting the PFE (arrow) which is hyperintense in black-blood T2-weighted coronal section.

Figure

A

and

B

Transthoracic

echocardiography

and

transoesophageal

echocardiography

showing

the

mass

over

the

pulmonary

valve

PV

arrow

C

Cardiac

magnetic

resonance

CMR

Discovery

General

Electric

Healthcare

T

Unit

Milwaukee

WI

USA

scan

images

showing

a

spherical

mass

arrow

mm

in

dimension

attached

to

the

anterior

leaflet

of

the

PV

The

papillary

fibroelastoma

PFE

appears

hypointense

compared

with

heart

chambers

in

this

steady

state

free

precession

sequence

D

CMR

highlighting

the

PFE

arrow

which

is

hyperintense

in

black

blood

coronal

section


Figure 5 Lateral knee x ray of (A) patient 3a at 20 years and (B) patient 5b at 28 years showing a double layered patella. Persistence of this finding into adulthood indicates a true anatomical variant and is a useful diagnostic clue.

Figure

Lateral

knee

x

ray

of

A

patient

at

years

and

B

patient

at

years

showing

a

double

layered

patella

Persistence

of

this

finding

into

adulthood

indicates

a

true

anatomical

variant

and

is

a

useful

diagnostic

clue


Fig. 3. (A-D) Imaging studies showing midline and intraauricular malformations. (A) Magnetic resonance imaging (MRI) (axial T1 with gadolinium) at 14 years of age, showing hypoplastic lateral and posterior semicircular canals (long arrows) and dysplastic vestibule (short arrow). (B) MRI at 14 years of age, showing Mondini dysplasia of the partition of the cochlea. (C) MRI at 14 years of age, showing decreased anterior pituitary volume (160 mm3). (D) MRI at 14 years of age, showing olfactory bulb aplasia (R) and hypoplasia (L). R, right; L, left.

Fig

A

D

Imaging

studies

showing

midline

and

intraauricular

malformations

A

Magnetic

resonance

imaging

MRI

axial

with

gadolinium

at

years

of

age

showing

hypoplastic

lateral

and

posterior

semicircular

canals

long

arrows

and

dysplastic

vestibule

short

arrow

B

MRI

at

years

of

age

showing

Mondini

dysplasia

of

the

partition

of

the

cochlea

C

MRI

at

years

of

age

showing

decreased

anterior

pituitary

volume

D

MRI

at

years

of

age

showing

olfactory

bulb

aplasia

R

and

hypoplasia

L

R

right

L

left


Fig. 5. Methylated arginine 17 on histone H3. Light and fluorescent micrographs of mouse immature oocytes, fertilized eggs and early embryonic stages stained for the Me(Arg17)H3 modification (F-J, red) and nucleic acid (K-O, green). (A,F,K) Immature oocyte nuclei displayed high levels of this modification in a punctate manner throughout the entire nuclear region excluding the nucleolus. (B,G,L) At fertilization, diffuse punctate cytoplasmic Me(Arg17)H3 staining is seen with no apparent staining observed on the metaphase plate (asterisks). (C,H,M) At the pronuclear stage, however, the modification is associated with chromatin in both pronuclei at similar levels. In all of the subsequent developmental stages tested, punctate cytoplasmic staining with little or no chromatin staining is observed in metaphase stage blastomeres (J, O, arrows). There is also little or no staining in anaphase stage blastomeres (I, N, arrows). This modification also stains cumulus cell nuclei and only stains polar bodies faintly (data not shown). Fluorescent images represent single confocal sections, therefore only nuclei found within the optical section can be visualized.

Fig

Methylated

arginine

on

histone

Light

and

fluorescent

micrographs

of

mouse

immature

oocytes

fertilized

eggs

and

early

embryonic

stages

stained

for

the

modification

F

J

red

and

nucleic

acid

K

O

green

A

F

K

Immature

oocyte

nuclei

displayed

high

levels

of

this

modification

in

a

punctate

manner

throughout

the

entire

nuclear

region

excluding

the

nucleolus

B

G

L

At

fertilization

diffuse

punctate

cytoplasmic

staining

is

seen

with

no

apparent

staining

observed

on

the

metaphase

plate

asterisks

C

H

M

At

the

pronuclear

stage

however

the

modification

is

associated

with

chromatin

in

both

pronuclei

at

similar

levels

In

all

of

the

subsequent

developmental

stages

tested

punctate

cytoplasmic

staining

with

little

or

no

chromatin

staining

is

observed

in

metaphase

stage

blastomeres

J

O

arrows

There

is

also

little

or

no

staining

in

anaphase

stage

blastomeres

I

N

arrows

This

modification

also

stains

cumulus

cell

nuclei

and

only

stains

polar

bodies

faintly

data

not

shown

Fluorescent

images

represent

single

confocal

sections

therefore

only

nuclei

found

within

the

optical

section

can

be

visualized


Fig. 2. Pictures after the nasal intubation of a 61-year-old man with schizophrenia who drank hot water estimated to be 90°C. A, The larynx as observed using a bronchoscope immediately after intubation. B, Computed tomography of the larynx area, showing the intubation tube (yellow arrow). C, Schema of photograph A illustrating the swollen epiglottis (i) and the intubation tube (ii).

Fig

Pictures

after

the

nasal

intubation

of

a

old

man

with

schizophrenia

who

drank

hot

water

estimated

to

be

C

A

The

larynx

as

observed

using

a

bronchoscope

immediately

after

intubation

B

Computed

tomography

of

the

larynx

area

showing

the

intubation

tube

yellow

arrow

C

Schema

of

photograph

A

illustrating

the

swollen

epiglottis

i

and

the

intubation

tube

ii


Fig. 3. CT imaging of the paratracheal mass before (right) and after (left) aspiration using the EBUS needle.

Fig

CT

imaging

of

the

paratracheal

mass

before

right

and

after

left

aspiration

using

the

EBUS

needle


Figure 5 Marked reduction in extent of gadolinium enhancement following immunotherapy in Patient 2. Axial T 1 MRI brain with gadolinium. (A) At time of relapse, off of all immunosuppressive therapy and prior to brain biopsy. (B) Near complete resolution of gadolinium enhancing lesions following chronic oral prednisone. (C) Recurrent gadolinium enhancing lesions following discontinuation of prednisone. (D) Improvement and stability for over 1.5 years on methotrexate monotherapy.

Figure

Marked

reduction

in

extent

of

gadolinium

enhancement

following

immunotherapy

in

Patient

Axial

T

MRI

brain

with

gadolinium

A

At

time

of

relapse

off

of

all

immunosuppressive

therapy

and

prior

to

brain

biopsy

B

Near

complete

resolution

of

gadolinium

enhancing

lesions

following

chronic

oral

prednisone

C

Recurrent

gadolinium

enhancing

lesions

following

discontinuation

of

prednisone

D

Improvement

and

stability

for

over

years

on

methotrexate

monotherapy


Fig. 1 Example of tumor heterogeneity for the asphericity assessment in a patient diagnosed with a Gleason score 6 prostate cancer. A-D Example of a patient diagnosed with a Gleason score 6 prostate cancer in the right peripheral zone of the apex of the prostate. A, B Corresponding orientations (transversal (A 1 ), coronal (A 2 ), and sagittal (A 3 )) are shown for 68Gallium-labeled prostate-specific membrane antigen positron emission tomography, fused with computed tomography (B 1-3 ). Based on positron emission tomography, an avid tumor was delineated in all three planes using the rover software. C, D Corresponding magnetic resonance imaging in the high-resolution T2 turbo spin echo (C) and diffusion-weighted images (D) in axial images confirm the presence of the malignant lesion at the respective location. HR: high-resolution, DWI: diffusion-weighted imaging

Fig

Example

of

tumor

heterogeneity

for

the

asphericity

assessment

in

a

patient

diagnosed

with

a

Gleason

score

prostate

cancer

A

D

Example

of

a

patient

diagnosed

with

a

Gleason

score

prostate

cancer

in

the

right

peripheral

zone

of

the

apex

of

the

prostate

A

B

Corresponding

orientations

transversal

A

coronal

A

and

sagittal

A

are

shown

for

labeled

prostate

specific

membrane

antigen

positron

emission

tomography

fused

with

computed

tomography

B

Based

on

positron

emission

tomography

an

avid

tumor

was

delineated

in

all

three

planes

using

the

rover

software

C

D

Corresponding

magnetic

resonance

imaging

in

the

high

resolution

turbo

spin

echo

C

and

diffusion

weighted

images

D

in

axial

images

confirm

the

presence

of

the

malignant

lesion

at

the

respective

location

HR

high

resolution

DWI

diffusion

weighted

imaging


Fig. 1. Computed tomography (CT) scan findings of the chest. Multiple nodules with ground glass opacity halo in the left upper lung field (A) and ill defined patches of nodular ground glass opacity are shown in the right middle (B) and the right lower lung field (C, D), which involve mainly the peripheral regions of the both lungs (arrows).

Fig

Computed

tomography

CT

scan

findings

of

the

chest

Multiple

nodules

with

ground

glass

opacity

halo

in

the

left

upper

lung

field

A

and

ill

defined

patches

of

nodular

ground

glass

opacity

are

shown

in

the

right

middle

B

and

the

right

lower

lung

field

C

D

which

involve

mainly

the

peripheral

regions

of

the

both

lungs

arrows


Figure 3. Microcrystalline Au deposited on glass. (a) Standard BSE imaging at 6 keV; (b) Sample in 1 kV/mm, landing energy of electrons 5 eV.

Figure

Microcrystalline

Au

deposited

on

glass

a

Standard

BSE

imaging

at

keV

b

Sample

in

kV

mm

landing

energy

of

electrons

eV.


Fig. 5 A 70-year-old woman with a sclerotic bone metastasis of breast cancer in thoracic vertebral body 10. a PET image reconstructed using the standard CTACmap shows an FDG-avid lesion in the left anterior aspect of T10. b Standard CTAC map shows that the bone lesion is sclerotic. c PET image reconstructed using the modified CT AC map. d In the modified CT AC map bone is substituted by soft tissue. In this case modification of the AC map has resulted in underestimation of FDG uptake by 23 % in this bone metastasis in the modified PET image

Fig

A

old

woman

with

a

sclerotic

bone

metastasis

of

breast

cancer

in

thoracic

vertebral

body

a

PET

image

reconstructed

using

the

standard

CTACmap

shows

an

FDG

avid

lesion

in

the

left

anterior

aspect

of

b

Standard

CTAC

map

shows

that

the

bone

lesion

is

sclerotic

c

PET

image

reconstructed

using

the

modified

CT

AC

map

d

In

the

modified

CT

AC

map

bone

is

substituted

by

soft

tissue

In

this

case

modification

of

the

AC

map

has

resulted

in

underestimation

of

FDG

uptake

by

in

this

bone

metastasis

in

the

modified

PET

image


Fig. 1. a , b A 66-year-old Caucasian man presented with a right facial capillary malformation and a left orange-colored choroidal mass. c – e The lesion is hyperautofluorescent and hypofluorescent on fluorescein indocyanine green angiography. f On B-scan ultrasound, the lesion is bilobed, echodense and measures 6.0 mm in apical height and 16.3 mm in its greatest basal dimension. Associated serous retinal detachment is present overlying the lesion and inferiorly. g T1-weighted MRI shows gadolinium enhancement of the lesion and multiple cerebral metastases (thick arrow). h DiffQuik stain (original magnification ×400) of ascitic fluid cytology shows small-to-intermediate malignant cells arranged in cohesive clusters with nuclear molding (thin arrow).

Fig

a

b

A

old

Caucasian

man

presented

with

a

right

facial

capillary

malformation

and

a

left

orange

colored

choroidal

mass

c

e

The

lesion

is

hyperautofluorescent

and

hypofluorescent

on

fluorescein

indocyanine

green

angiography

f

On

B

scan

ultrasound

the

lesion

is

bilobed

echodense

and

measures

mm

in

apical

height

and

mm

in

its

greatest

basal

dimension

Associated

serous

retinal

detachment

is

present

overlying

the

lesion

and

inferiorly

g

MRI

shows

gadolinium

enhancement

of

the

lesion

and

multiple

cerebral

metastases

thick

arrow

h

DiffQuik

stain

original

magnification

of

ascitic

fluid

cytology

shows

small

to

intermediate

malignant

cells

arranged

in

cohesive

clusters

with

nuclear

molding

thin

arrow


Figure 3. Converging genual and perigenual abnormalities in borderline personality disorder. An overlap of several contrasts involving medial-frontal abnormalities are shown in sagittal (A) and axial (B) slices. White matter alterations in fractional anisotropy shown in blue enclose medial clusters of: 1) altered mean diffusivity shown in red, 2) abnormal global brain connectivity shown in green, and 3) a small region of increased connectivity with the left amygdala (cluster of abnormal amplitude of lowfrequency fluctuations), which is shown in purple (p corrected , .05) with an enlarged version (p uncorrected , .001) shown in yellow.

Figure

Converging

genual

and

perigenual

abnormalities

in

borderline

personality

disorder

An

overlap

of

several

contrasts

involving

medial

frontal

abnormalities

are

shown

in

sagittal

A

and

axial

B

slices

White

matter

alterations

in

fractional

anisotropy

shown

in

blue

enclose

medial

clusters

of

altered

mean

diffusivity

shown

in

red

abnormal

global

brain

connectivity

shown

in

green

and

a

small

region

of

increased

connectivity

with

the

left

amygdala

cluster

of

abnormal

amplitude

of

lowfrequency

fluctuations

which

is

shown

in

purple

p

corrected

with

an

enlarged

version

p

uncorrected

shown

in

yellow


Figure 1. A well circumscribed enhancing neoplasm involving the vermis and 4th ventricle was present (Sagittal T1-weighted MR (a). Microcalcifications were also present on histologic examination (b). The neoplasm was lobulated and low grade with round to oval cells reminiscent of pilocytic astrocytoma (c). In addition distinctive rosettes reflecting neuronal differentiation were present (d). Synaptophysin was strongly expressed in rosettes and perivascular pseudorosettes (e). Immunoreactivity for pERK was strong and diffuse (f).

Figure

A

well

circumscribed

enhancing

neoplasm

involving

the

vermis

and

ventricle

was

present

Sagittal

MR

a

Microcalcifications

were

also

present

on

histologic

examination

b

The

neoplasm

was

lobulated

and

low

grade

with

round

to

oval

cells

reminiscent

of

pilocytic

astrocytoma

c

In

addition

distinctive

rosettes

reflecting

neuronal

differentiation

were

present

d

Synaptophysin

was

strongly

expressed

in

rosettes

and

perivascular

pseudorosettes

e

Immunoreactivity

for

pERK

was

strong

and

diffuse

f


Fig. 2. Coronal section of the brain, at 8 weeks after KA injection, examined by H&E stain revealed relatively intact CA2 and CA3 neurons of the right hippocampus (A,×40), and moderate loss of CA3 neurons in the left hippocampus (B,×80).

Fig

Coronal

section

of

the

brain

at

weeks

after

KA

injection

examined

by

H&E

stain

revealed

relatively

intact

and

neurons

of

the

right

hippocampus

and

moderate

loss

of

neurons

in

the

left

hippocampus


Fig. 8 a Selection of trabecular boundary in IL2DI (red points). b Smooth version of (a) (red points). c Trabecular boundary in transverse view (red, rough trabecular boundary; green, optimized trabecular boundary; white, overlap of green and red)

Fig

a

Selection

of

trabecular

boundary

in

red

points

b

Smooth

version

of

a

red

points

c

Trabecular

boundary

in

transverse

view

red

rough

trabecular

boundary

green

optimized

trabecular

boundary

white

overlap

of

green

and

red


Figure 2: Preoperative T1 axial magnetic resonance images, both noncontrast enhanced (a) and contrast enhanced (b) images, showing choroid plexus tissue protruding from foramen of Luschka

Figure

Preoperative

axial

magnetic

resonance

images

both

noncontrast

enhanced

a

and

contrast

enhanced

b

images

showing

choroid

plexus

tissue

protruding

from

foramen

of

Luschka


Figure 1: T2-weighed magnetic resonance imaging at 9 (a, b) and 32 (c, d) weeks of gestation. (a) Bilateral pelvic masses with a horizontal view. A right-sided multilocular mass (arrow) and left-sided unilocular mass (asterisk) are shown. We suspected bilateral ovarian tumors at this point. (b) Sagittal view. The left-sided unilocular mass (asterisk) is shown. (c) Horizontal view. The right-sided multilocular mass (arrow) is involved in or at least is located very close to the large mass (star). (d) Sagittal view. The left-sided mass (star) occupies the pelvic cavity.

Figure

magnetic

resonance

imaging

at

a

b

and

c

d

weeks

of

gestation

a

Bilateral

pelvic

masses

with

a

horizontal

view

A

right

sided

multilocular

mass

arrow

and

left

sided

unilocular

mass

asterisk

are

shown

We

suspected

bilateral

ovarian

tumors

at

this

point

b

Sagittal

view

The

left

sided

unilocular

mass

asterisk

is

shown

c

Horizontal

view

The

right

sided

multilocular

mass

arrow

is

involved

in

or

at

least

is

located

very

close

to

the

large

mass

star

d

Sagittal

view

The

left

sided

mass

star

occupies

the

pelvic

cavity